Compile Data Set for Download or QSAR
maximum 50k data
Found 212 of ic50 for UniProtKB: P30543
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50018697(CHEMBL3291310)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at adenosine A2A receptor in 5-HT-treated Wistar rat femoral vein assessed as inhibition of 2-octyn-1-yladenosine-induced vasodil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50095604(4-[3-(8-Cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetr...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of [3H]-ZM-241,385 binding to adenosine A2A receptor(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50018695(CHEMBL3291308)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at adenosine A2A receptor in 5-HT-treated Wistar rat femoral vein assessed as inhibition of 2-octyn-1-yladenosine-induced vasodil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM571388(US11440916, HZ10136)
Affinity DataIC50:  1.10nMAssay Description:The IC50 (nM) values of the example compound HZ10126 and several reference compounds against the rat A2A receptor were measured in an in vitro assay,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50202993(2-furan-2-yl-7-[2-(4-phenyl-piperazin-1-yl)-ethyl]...)
Affinity DataIC50:  1.20nMAssay Description:The IC50 (nM) values of the example compound HZ10126 and several reference compounds against the rat A2A receptor were measured in an in vitro assay,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50039676(4-Fluorosulfonyl-benzoic acid 3-(8-cyclopentyl-2,6...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of [3H]-ZM-241,385 binding to adenosine A2A receptor(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50048466(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Affinity DataIC50:  1.80nMAssay Description:The IC50 (nM) values of the example compound HZ10126 and several reference compounds against the rat A2A receptor were measured in an in vitro assay,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50018693(CHEMBL3291306)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at adenosine A2A receptor in 5-HT-treated Wistar rat femoral vein assessed as inhibition of 2-octyn-1-yladenosine-induced vasodil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1/A2a/A2b/A3(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50009552(2-[6-Amino-2-(2-morpholin-4-yl-ethylamino)-purin-9...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [3H]CHA from rat brain adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50202986(2-furan-2-yl-7-(2-{4-[4-(2-methoxy-ethoxy)-phenyl]...)
Affinity DataIC50:  2.5nMAssay Description:The IC50 (nM) values of the example compound HZ10126 and several reference compounds against the rat A2A receptor were measured in an in vitro assay,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataIC50:  2.80nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50095602(4-[3-(8-Cyclopentyl-2,6-dioxo-1-propyl-1,2,6,7-tet...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of [3H]-ZM-241,385 binding to adenosine A2A receptor(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50018696(CHEMBL3291309)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at adenosine A2A receptor in 5-HT-treated Wistar rat femoral vein assessed as inhibition of 2-octyn-1-yladenosine-induced vasodil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataIC50:  3.30nMAssay Description:Binding affinity for Adenosine A2A receptor from rat striatal membranes using [3H]-CGH 21680More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50018692(CHEMBL3291305)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at adenosine A2A receptor in 5-HT-treated Wistar rat femoral vein assessed as inhibition of 2-octyn-1-yladenosine-induced vasodil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1/A2a/A2b/A3(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224560(CHEMBL605654)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]CHA from rat brain adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50053927(7-Methyl-2-phenyl-4-((E)-styryl)-1,4-dihydro-quino...)
Affinity DataIC50:  4.77nMAssay Description:Binding affinity for Adenosine A2A receptor from rat striatal membranes using [3H]-CGH 21680More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50018688(CHEMBL3291301)
Affinity DataIC50:  5.10nMAssay Description:Antagonist activity at adenosine A2A receptor in 5-HT-treated Wistar rat femoral vein assessed as inhibition of 2-octyn-1-yladenosine-induced vasodil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50023492(5-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazo...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50018689(CHEMBL3291302)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at adenosine A2A receptor in 5-HT-treated Wistar rat femoral vein assessed as inhibition of 2-octyn-1-yladenosine-induced vasodil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataIC50:  7.05nMAssay Description:Displacement of [3H]MSX-2 from rat adenosine A2A receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50382493(CHEMBL2024116)
Affinity DataIC50:  9.70nMAssay Description:Antagonist activity at rat adenosine 2A receptor assessed as reduction in cAMP level in presence of 0.1 uM adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50095605(4-[3-(8-Cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetr...)
Affinity DataIC50: >10nMAssay Description:Inhibition of [3H]-ZM-241,385 binding to adenosine A2A receptor(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50095603(4-[5-(8-Cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetr...)
Affinity DataIC50: >10nMAssay Description:Inhibition of [3H]-ZM-241,385 binding to adenosine A2A receptor(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50095606(4-(8-Cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahy...)
Affinity DataIC50: >10nMAssay Description:Inhibition of [3H]-ZM-241,385 binding to adenosine A2A receptor(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009535((CGS 22,989) 2-[6-Amino-2-(2-cyclohex-1-enyl-ethyl...)
Affinity DataIC50:  13nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50275963((S)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(3-fluor...)
Affinity DataIC50:  15nMAssay Description:Activity at adenosine A2A receptor in rat PC12 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataIC50:  15nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009543(2-{6-Amino-2-[2-(5,6,7,8-tetrahydro-naphthalen-2-y...)
Affinity DataIC50:  17nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataIC50:  17nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50023505(2-Furan-2-yl-9-methoxy-[1,2,4]triazolo[1,5-c]quina...)
Affinity DataIC50:  19nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004571(8-Chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin...)
Affinity DataIC50:  21nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009509((CGS 22,492) 2-[6-Amino-2-(2-cyclohexyl-ethylamino...)
Affinity DataIC50:  22nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50009546(2-{6-Amino-2-[2-(4-methoxy-phenyl)-ethylamino]-pur...)
Affinity DataIC50:  23nMAssay Description:Binding affinity for Adenosine A2A receptor using [3H]-ZM-241,38 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM50018691(CHEMBL3291304)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at adenosine A2A receptor in 5-HT-treated Wistar rat femoral vein assessed as inhibition of 2-octyn-1-yladenosine-induced vasodil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015779(7,8-Dichloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxa...)
Affinity DataIC50:  23nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009546(2-{6-Amino-2-[2-(4-methoxy-phenyl)-ethylamino]-pur...)
Affinity DataIC50:  23nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009515(2-[6-Amino-2-(2-hydroxy-2-phenyl-propylamino)-puri...)
Affinity DataIC50:  24nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]-NECA from adenosine A2 receptor of rat striatal membraneMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009513(2-[2-(2-Adamantan-1-yl-ethylamino)-6-amino-purin-9...)
Affinity DataIC50:  27nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50023496(2-Furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl...)
Affinity DataIC50:  27nMAssay Description:Inhibition of binding to Adenosine-2 receptor using [3H]NECA in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015765(8-Chloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxalin-...)
Affinity DataIC50:  28nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Yamasa

Curated by ChEMBL
LigandPNGBDBM26236(CHEMBL487569 | N-[6-(3,5-dimethoxyphenyl)-2-(3,5-d...)
Affinity DataIC50:  29nMAssay Description:Activity at adenosine A2A receptor in rat PC12 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015810(7-Chloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxalin-...)
Affinity DataIC50:  29nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50453087(CHEMBL2374394)
Affinity DataIC50:  30nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015829(8-Chloro-1-(4-chloro-phenyl)-[1,2,4]triazolo[4,3-a...)
Affinity DataIC50:  33nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009541(2-[6-Amino-2-(2-naphthalen-2-yl-ethylamino)-purin-...)
Affinity DataIC50:  35nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015784(1-Ethyl-7-methoxy-[1,2,4]triazolo[4,3-a]quinoxalin...)
Affinity DataIC50:  36nMAssay Description:Evaluated for the binding affinity towards the Adenosine A2 receptor in corpora striata of rats using [3H]NECA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50453086(CHEMBL2374393)
Affinity DataIC50:  42nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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