Affinity DataKi: 0.700nM ΔG°: -13.0kcal/mole EC50: 0.290nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -12.8kcal/mole EC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.900nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 2.20nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 2.90nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
Affinity DataEC50: 4.20nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nM ΔG°: -13.3kcal/mole EC50: 4.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 5.20nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 5.80nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -12.3kcal/mole EC50: 6.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -11.7kcal/mole EC50: 6.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataEC50: 6.5nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as induction of cAMP production after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 7.30nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataEC50: 7.30nMAssay Description:Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 7.30nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nM ΔG°: -10.8kcal/mole EC50: 9.60nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataKi: 7nM ΔG°: -11.0kcal/mole EC50: 17.5nMpH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataKi: 10nM ΔG°: -11.3kcal/mole EC50: 21.6nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -12.3kcal/mole EC50: 24nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at human 5HT6 expressed in HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataEC50: 31nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...More data for this Ligand-Target Pair
Affinity DataEC50: 31nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair