Compile Data Set for Download or QSAR
maximum 50k data
Found 195 of ic50 for UniProtKB: P31389
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50007538(8-(2-Azetidin-1-yl-ethyl)-3-chloro-6-methyl-7,8-di...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of guinea pig histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50131441(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-...)
Affinity DataIC50:  1.58nMAssay Description:Potency against histamine H1 receptor on guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50007542(3-Chloro-8-(2-dimethylamino-ethyl)-6-methyl-7,8-di...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019624(1-(2-Ethoxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-yl)...)
Affinity DataIC50:  6.10nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019595(2-(4-Methyl-piperazin-1-yl)-1-(2-phenoxy-ethyl)-1H...)
Affinity DataIC50:  6.90nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019605(1-(2-Ethoxy-ethyl)-2-(4-pentyl-[1,4]diazepan-1-yl)...)
Affinity DataIC50:  7.40nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50017371(1-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity of the compound against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019644(1-(2-Ethoxy-ethyl)-2-(4-propyl-[1,4]diazepan-1-yl)...)
Affinity DataIC50:  8.40nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019643(2-(4-Butyl-[1,4]diazepan-1-yl)-1-(2-ethoxy-ethyl)-...)
Affinity DataIC50:  8.40nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019602(1-(2-Ethoxy-ethyl)-2-(4-hexyl-piperazin-1-yl)-1H-b...)
Affinity DataIC50:  8.60nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM76863(3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzim...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity of the compound against Tritiated [3H]- mepyramine binding to Histamine H1 receptor in guinea pig cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019628(2-(4-Methyl-[1,4]diazepan-1-yl)-1-(2-phenoxy-ethyl...)
Affinity DataIC50:  9.10nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019609(2-(4-Methyl-[1,4]diazepan-1-yl)-1-(2-prop-2-ynylox...)
Affinity DataIC50:  9.90nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019636(2-(4-Methyl-piperazin-1-yl)-1-(2-vinyloxy-ethyl)-1...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019607(1-(2-Ethoxy-ethyl)-2-(4-methyl-piperazin-1-yl)-1H-...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019618(1-(2-Allyloxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-y...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019614(1-(2-Butoxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-yl)...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50089149(2-Benzyl-9-phenyl-2,3,4,4a-tetrahydro-1H-indeno[2,...)
Affinity DataIC50:  11nMAssay Description:In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019629(1-(2-Ethoxy-ethyl)-2-piperazin-1-yl-1H-benzoimidaz...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019596(2-(4-Methyl-piperazin-1-yl)-1-(2-prop-2-ynyloxy-et...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019634(1-(2-Methoxy-ethyl)-2-(4-methyl-piperazin-1-yl)-1H...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019597(2-(4-Butyl-piperazin-1-yl)-1-(2-ethoxy-ethyl)-1H-b...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019625(2-(4-Benzyl-[1,4]diazepan-1-yl)-1-(2-ethoxy-ethyl)...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019631(1-(2-Ethoxy-ethyl)-2-(4-propyl-piperazin-1-yl)-1H-...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019630(1-(2-Ethoxy-ethyl)-2-(4-ethyl-[1,4]diazepan-1-yl)-...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019611(2-(4-Methyl-[1,4]diazepan-1-yl)-1-(2-propoxy-ethyl...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50089150(2-Ethyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-...)
Affinity DataIC50:  17nMAssay Description:In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019617(1-(2-Allyloxy-ethyl)-2-(4-methyl-piperazin-1-yl)-1...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019616(1-Benzyl-2-(4-methyl-piperazin-1-yl)-1H-benzoimida...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019635(1-(2-Ethoxy-ethyl)-2-(4-ethyl-piperazin-1-yl)-1H-b...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019619(2-(4-Methyl-piperazin-1-yl)-1-propoxymethyl-1H-ben...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019626(2-(4-Methyl-piperazin-1-yl)-1-pentyl-1H-benzoimida...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019593(1-(2-Ethylsulfanyl-ethyl)-2-(4-methyl-piperazin-1-...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019599(2-(4-Methyl-piperazin-1-yl)-1-(2-propoxy-ethyl)-1H...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50089148(((3R,4S)-1-Ethyl-4-hydroxy-4-phenyl-piperidin-3-yl...)
Affinity DataIC50:  23nMAssay Description:In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50007536(CHEMBL24517 | [3-(5-Chloro-pyridin-2-yl)-3-pyridin...)
Affinity DataIC50:  24nMAssay Description:Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019639(2-[1,4]Diazepan-1-yl-1-(2-ethoxy-ethyl)-1H-benzoim...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019632(1-Hexyl-2-(4-methyl-piperazin-1-yl)-1H-benzoimidaz...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50089146(((3R,4S)-4-Hydroxy-1-methyl-4-phenyl-piperidin-3-y...)
Affinity DataIC50:  26nMAssay Description:In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019627(2-(4-Benzyl-piperazin-1-yl)-1-(2-ethoxy-ethyl)-1H-...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50089144(2-Methyl-9-phenyl-2,3,4,4a-tetrahydro-1H-indeno[2,...)
Affinity DataIC50:  28nMAssay Description:In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50156861(2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-6-fluor...)
Affinity DataIC50:  28nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50007539(8-(2-Dimethylamino-ethyl)-6-methyl-7,8-dihydro-6H-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019601(1-(2-Ethoxy-ethyl)-2-(4-pentyl-piperazin-1-yl)-1H-...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50019592(1-(2-Ethoxy-ethyl)-2-(4-phenethyl-piperazin-1-yl)-...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibition of histamine-induced contractions in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50156893(2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperid...)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Affinity DataIC50:  34nMAssay Description:In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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