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Found 1500 of ic50 for UniProtKB: P07858
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50602545(CHEMBL4596647)
Affinity DataIC50:  0.149nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM420296(Advanced SARS-CoV-2 Inhibitor 11a | MPI10 | acs.jm...)
Affinity DataIC50:  0.210nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50602542(CHEMBL4594870)
Affinity DataIC50:  0.278nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50602544(CHEMBL4594757)
Affinity DataIC50:  0.416nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM509972(Advanced SARS-CoV-2 Inhibitor 6e | acs.jmedchem.1c...)
Affinity DataIC50: <0.5nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM509973(Advanced SARS-CoV-2 Inhibitor 6j | acs.jmedchem.1c...)
Affinity DataIC50: <0.5nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50201701(CHEMBL390474 | cis-4-(2,3-dimethylphenoxy)-6-oxa-1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM16510((2S,3S)-3-[[(1S)-1-(isoamylcarbamoyl)-3-methyl-but...)
Affinity DataIC50:  1.53nMpH: 6.8 T: 2°CAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107639(3-{2-[2-(4-Chloro-2-fluoro-benzoylamino)-3-m-tolyl...)
Affinity DataIC50:  2nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50201705((1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM16509((2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarb...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of cathepsin B (unknown origin) assessed as reduction in 7-amino-4-methylcoumarin formation using Z-Arg-Arg-MCA as substrate preincubated ...More data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM16508((2S)-1-[(2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of cathepsin B (unknown origin) assessed as reduction in 7-amino-4-methylcoumarin formation using Z-Arg-Arg-MCA as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50163831((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory concentration against human cathepsin B using 10 uM Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM16509((2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarb...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of cathepsin B in human SH-SY5Y cells using RR-AMC as substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50250153(3-acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-ni...)
Affinity DataIC50:  3.11nMAssay Description:Inhibition of human liver cathepsin B after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM16509((2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarb...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of cathepsin B (unknown origin) using RR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated fo...More data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135541(5-{(R)-2-Cyano-2-[(S)-2-(3-oxo-1,3-dihydro-isobenz...)
Affinity DataIC50:  4.10nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM16509((2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarb...)
Affinity DataIC50:  4.40nMpH: 5.5 T: 2°CAssay Description:Inhibition of cathepsin B was assayed in reaction buffer (50 mM NaOAc-HCl, 2 mM dithiothreitol, 2 mM EDTA, pH 5.5) containing 20 µM substrate an...More data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of cathepsin B (unknown origin) using Cbz-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135543(3-{(R)-2-Cyano-2-[(S)-2-(2-methyl-1,3-dioxo-2,3-di...)
Affinity DataIC50:  4.90nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135533((S)-N-[(R)-Cyano-(3-tetrazol-1-yl-benzyloxymethyl)...)
Affinity DataIC50:  5nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50:  5nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50:  5nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50201700((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135535(3-{(R)-2-Cyano-2-[(S)-2-(1,1-dimethyl-3-oxo-1,3-di...)
Affinity DataIC50:  5.30nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135537(3-{(R)-2-Cyano-2-[(S)-2-(3-oxo-indan-5-ylamino)-3-...)
Affinity DataIC50:  5.30nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107646(3-[4-Cyano-4-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50:  5.60nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human Cathepsin B using Cbz-Phe-Arg-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135546(3-{(R)-2-Cyano-2-[(S)-2-(3-oxo-1,3-dihydro-isobenz...)
Affinity DataIC50:  6.5nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataIC50:  6.80nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50201699((1R,2S)-2-isobutoxy-7-oxa-5-aza-bicyclo[3.2.1]octa...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135532(3-{2-cyano-2-[1-(3-methyloxycarbonylanilino)-2-(3-...)
Affinity DataIC50:  8.60nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135544(2-Chloro-5-[(R)-2-cyano-2-((S)-2-phenylamino-3-m-t...)
Affinity DataIC50:  8.70nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50549374(CHEMBL4746374)
Affinity DataIC50:  9nMAssay Description:Inhibition of human cathepsin B at pH 6 using Z-Phe-Arg-AMC fluorogenic peptide as substrate preincubated for 2 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50331787((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Cat B in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50331787((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50:  9nMAssay Description:Reversible inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50135547(3-{(R)-2-Cyano-2-[(S)-2-(2-methyl-3-oxo-2,3-dihydr...)
Affinity DataIC50:  9.30nMAssay Description:Inhibtitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50286441((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107620(3-[2-(2-Benzoylamino-3-m-tolyl-propionylamino)-2-c...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107620(3-[2-(2-Benzoylamino-3-m-tolyl-propionylamino)-2-c...)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107629(3-[2-Cyano-2-(2-pentanoylamino-3-m-tolyl-propionyl...)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107639(3-{2-[2-(4-Chloro-2-fluoro-benzoylamino)-3-m-tolyl...)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107638(CHEMBL336436 | N-(Benzyloxymethyl-cyano-methyl)-2-...)
Affinity DataIC50:  10.2nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50252525(CHEMBL493039 | benzyl 1-(2-cyanopiperazin-1-yl)-3-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50107650(CHEMBL138661 | N-Cyanomethyl-3-(3,5-dimethyl-pheny...)
Affinity DataIC50:  11.9nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50510758(CHEMBL4582255)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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