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Found 88 of ic50 for UniProtKB: P09668
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)
Affinity DataIC50: >10nMAssay Description:Inhibition of cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50148298(((S)-1-Formyl-pentyl)-carbamic acid (R)-1-benzyl-2...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50163831((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50148296(((S)-1-Formyl-pentyl)-carbamic acid (S)-1-methyl-2...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50:  110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50:  110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50:  110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50:  110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50250152(3-acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroq...)
Affinity DataIC50:  145nMAssay Description:Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50177501(CHEMBL203663 | {(S)-1-[(morpholine-4-carbonyl)-hyd...)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  190nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50177494(CHEMBL204605 | {(S)-1-[(morpholine-4-carbonyl)-hyd...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50: >500nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50165424((S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,...)
Affinity DataIC50: >500nMAssay Description:Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50163832((1S)-2-cyclohexyl-1-methylethyl (2S)-1-cyanopyrrol...)
Affinity DataIC50:  580nMAssay Description:Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50:  1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50:  1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50:  1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50:  1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152526((1-(3-phenylpropyl)cyclobutyl)methyl(S)-1,2-dioxo-...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50165425(CHEMBL195963 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152521((1-phenethylcyclobutyl)methyl(S)-1,2-dioxo-1-((R)-...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50201701(CHEMBL390474 | cis-4-(2,3-dimethylphenoxy)-6-oxa-1...)
Affinity DataIC50:  2.65E+3nMAssay Description:Inhibition of human recombinant cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152522(2-methyl-2-phenylpropyl(S)-1,2-dioxo-1-((R)-1-phen...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50165420(CHEMBL197509 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152527((1-benzylcyclobutyl)methyl(S)-1,2-dioxo-1-((R)-1-p...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152523(CHEMBL180528 | [(S)-5-[(Morpholine-4-carbonyl)-ami...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152530(CHEMBL186650 | P2,P3 Ketoamide derivative)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152525(CHEMBL184403 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50152532(2,2-dimethyl-3-phenylpropyl(S)-1,2-dioxo-1-((R)-1-...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50201700((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-...)
Affinity DataIC50:  6.59E+3nMAssay Description:Inhibition of human recombinant cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50163838((1-Cyano-pyrrolidin-3-yl)-carbamic acid (S)-2-cycl...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50270029(2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-pro...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50186088((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50201699((1R,2S)-2-isobutoxy-7-oxa-5-aza-bicyclo[3.2.1]octa...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50201705((1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of cathepsin H after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453329(BDBM553832 | US10730826, Compound 47a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453330(BDBM553833 | US10730826, Compound 50a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453331(BDBM553834 | US10730826, Compound 55a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453332(BDBM553835 | US10730826, Compound 69a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453318(BDBM553824 | US10730826, Compound 18a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453329(BDBM553832 | US10730826, Compound 47a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453330(BDBM553833 | US10730826, Compound 50a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453331(BDBM553834 | US10730826, Compound 55a)
Affinity DataIC50: >1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
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