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Compile Data Set for Download or QSAR

Found 213 hits of ic50 for UniProtKB: P14679   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Homo sapiens (Human))
BDBM50269559
PNG
(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc(c(O)c1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-6,16-19H
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n/an/a 23n/an/an/an/an/an/a



Hiroshima University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measure...


J Nat Prod 80: 3172-3178 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00453
BindingDB Entry DOI: 10.7270/Q2VD71Z4
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287127
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES Oc1coc(COC(=O)N[C@@H](Cc2ccccc2)C(=O)OCc2cc(=O)c(O)co2)cc1=O
Show InChI InChI=1S/C22H19NO10/c24-17-7-14(30-11-19(17)26)9-32-21(28)16(6-13-4-2-1-3-5-13)23-22(29)33-10-15-8-18(25)20(27)12-31-15/h1-5,7-8,11-12,16,26-27H,6,9-10H2,(H,23,29)/t16-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Bioorg Med Chem Lett 6: 1303-1308 (1996)


Article DOI: 10.1016/0960-894X(96)00221-1
BindingDB Entry DOI: 10.7270/Q2V1259K
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50203985
PNG
((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...)
Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1
Show InChI InChI=1S/C15H12O5/c16-10-3-1-9(14(19)7-10)2-6-13(18)12-5-4-11(17)8-15(12)20/h1-8,16-17,19-20H/b6-2+
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n/an/a 70n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50203985
PNG
((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...)
Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1
Show InChI InChI=1S/C15H12O5/c16-10-3-1-9(14(19)7-10)2-6-13(18)12-5-4-11(17)8-15(12)20/h1-8,16-17,19-20H/b6-2+
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n/an/a 70n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50251013
PNG
(2,4,2',4'-tetrahydroxy-3'-prenylchalcone | CHEMBL4...)
Show SMILES CC(C)=CCc1c(O)ccc(C(=O)\C=C\c2ccc(O)cc2O)c1O
Show InChI InChI=1S/C20H20O5/c1-12(2)3-7-15-18(23)10-8-16(20(15)25)17(22)9-5-13-4-6-14(21)11-19(13)24/h3-6,8-11,21,23-25H,7H2,1-2H3/b9-5+
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n/an/a 80n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50251013
PNG
(2,4,2',4'-tetrahydroxy-3'-prenylchalcone | CHEMBL4...)
Show SMILES CC(C)=CCc1c(O)ccc(C(=O)\C=C\c2ccc(O)cc2O)c1O
Show InChI InChI=1S/C20H20O5/c1-12(2)3-7-15-18(23)10-8-16(20(15)25)17(22)9-5-13-4-6-14(21)11-19(13)24/h3-6,8-11,21,23-25H,7H2,1-2H3/b9-5+
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n/an/a 80n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50441626
PNG
(GLABRIDIN | US9783551, Compound 1)
Show SMILES CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c1ccc(O)cc1O
Show InChI InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate preincubated for 5 mins followed by substrate addition


J Nat Prod 80: 334-346 (2017)


Article DOI: 10.1021/acs.jnatprod.6b00783
BindingDB Entry DOI: 10.7270/Q2XD146V
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50172095
PNG
(CHEBI:69084 | GLYASPERIN D | Glyasperin D)
Show SMILES COc1cc2OC[C@H](Cc2c(OC)c1CC=C(C)C)c1ccc(O)cc1O
Show InChI InChI=1S/C22H26O5/c1-13(2)5-7-17-20(25-3)11-21-18(22(17)26-4)9-14(12-27-21)16-8-6-15(23)10-19(16)24/h5-6,8,10-11,14,23-24H,7,9,12H2,1-4H3/t14-/m0/s1
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n/an/a 154n/an/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 mins


J Nat Prod 79: 281-92 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00877
BindingDB Entry DOI: 10.7270/Q20V8FPM
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50529589
PNG
(CHEMBL4239110)
Show SMILES C\C(CO)=C/Cc1c(O)ccc(C(=O)\C=C\c2ccc(O)cc2O)c1O
Show InChI InChI=1S/C20H20O6/c1-12(11-21)2-6-15-18(24)9-7-16(20(15)26)17(23)8-4-13-3-5-14(22)10-19(13)25/h2-5,7-10,21-22,24-26H,6,11H2,1H3/b8-4+,12-2+
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n/an/a 170n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50529589
PNG
(CHEMBL4239110)
Show SMILES C\C(CO)=C/Cc1c(O)ccc(C(=O)\C=C\c2ccc(O)cc2O)c1O
Show InChI InChI=1S/C20H20O6/c1-12(11-21)2-6-15-18(24)9-7-16(20(15)26)17(23)8-4-13-3-5-14(22)10-19(13)25/h2-5,7-10,21-22,24-26H,6,11H2,1H3/b8-4+,12-2+
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n/an/a 170n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50172096
PNG
(CHEBI:69089 | GLYASPERIN C | Glyasperin C)
Show SMILES COc1c(CC=C(C)C)c(O)cc2OC[C@H](Cc12)c1ccc(O)cc1O
Show InChI InChI=1S/C21H24O5/c1-12(2)4-6-16-19(24)10-20-17(21(16)25-3)8-13(11-26-20)15-7-5-14(22)9-18(15)23/h4-5,7,9-10,13,22-24H,6,8,11H2,1-3H3/t13-/m0/s1
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n/an/a 177n/an/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 mins


J Nat Prod 79: 281-92 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00877
BindingDB Entry DOI: 10.7270/Q20V8FPM
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146416
PNG
((S)-2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C36H34N4O10/c41-24-12-10-22(11-13-24)15-30(35(46)47)39-34(45)29(16-23-18-37-27-9-5-4-8-26(23)27)38-33(44)28(14-21-6-2-1-3-7-21)40-36(48)50-19-25-17-31(42)32(43)20-49-25/h1-13,17-18,20,28-30,37,41,43H,14-16,19H2,(H,38,44)(H,39,45)(H,40,48)(H,46,47)/t28-,29-,30-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Bioorg Med Chem Lett 14: 2843-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.046
BindingDB Entry DOI: 10.7270/Q2N015ZH
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146418
PNG
((S)-2-{(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C34H33N3O10/c38-24-13-11-23(12-14-24)17-28(33(43)44)36-31(41)26(15-21-7-3-1-4-8-21)35-32(42)27(16-22-9-5-2-6-10-22)37-34(45)47-19-25-18-29(39)30(40)20-46-25/h1-14,18,20,26-28,38,40H,15-17,19H2,(H,35,42)(H,36,41)(H,37,45)(H,43,44)/t26-,27-,28-/m0/s1
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n/an/a 330n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Bioorg Med Chem Lett 14: 2843-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.046
BindingDB Entry DOI: 10.7270/Q2N015ZH
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50263336
PNG
(4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol | CHEMBL4...)
Show SMILES Oc1ccc(CCc2ccc(O)cc2O)c(O)c1
Show InChI InChI=1S/C14H14O4/c15-11-5-3-9(13(17)7-11)1-2-10-4-6-12(16)8-14(10)18/h3-8,15-18H,1-2H2
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n/an/a 370n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146415
PNG
((S)-2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C34H33N3O11/c38-23-10-6-21(7-11-23)15-26(31(42)36-28(33(44)45)16-22-8-12-24(39)13-9-22)35-32(43)27(14-20-4-2-1-3-5-20)37-34(46)48-18-25-17-29(40)30(41)19-47-25/h1-13,17,19,26-28,38-39,41H,14-16,18H2,(H,35,43)(H,36,42)(H,37,46)(H,44,45)/t26-,27-,28-/m0/s1
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n/an/a 390n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Bioorg Med Chem Lett 14: 2843-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.046
BindingDB Entry DOI: 10.7270/Q2N015ZH
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50264086
PNG
((2S,3R,4S,5R)-2-(4-(2,4-dihydroxyphenethyl)-3-hydr...)
Show SMILES O[C@@H]1CO[C@@H](Oc2ccc(CCc3ccc(O)cc3O)c(O)c2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C19H22O8/c20-12-5-3-10(14(21)7-12)1-2-11-4-6-13(8-15(11)22)27-19-18(25)17(24)16(23)9-26-19/h3-8,16-25H,1-2,9H2/t16-,17+,18-,19+/m1/s1
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n/an/a 430n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50292636
PNG
(4-hexyl resorcinol | ACRISORCIN | CHEMBL443605)
Show SMILES CCCCCCc1ccc(O)cc1O
Show InChI InChI=1S/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H3
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n/an/a 560n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Bioorg Med Chem 23: 6650-8 (2015)


Article DOI: 10.1016/j.bmc.2015.09.014
BindingDB Entry DOI: 10.7270/Q2DR2X9W
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50340788
PNG
(4-(beta-D-Cellobiopyranosyl)-2,2',4'-trihydroxybib...)
Show SMILES OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C26H34O14/c27-9-17-19(32)20(33)22(35)26(38-17)40-24-18(10-28)39-25(23(36)21(24)34)37-14-6-4-12(16(31)8-14)2-1-11-3-5-13(29)7-15(11)30/h3-8,17-36H,1-2,9-10H2/t17-,18-,19-,20+,21-,22-,23-,24-,25-,26+/m1/s1
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n/an/a 680n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50366430
PNG
(CHEMBL1794031)
Show SMILES CC[C@H](C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C19H21NO10/c1-3-10(2)17(18(25)29-6-11-4-13(21)15(23)8-27-11)20-19(26)30-7-12-5-14(22)16(24)9-28-12/h4-5,8-10,17,23-24H,3,6-7H2,1-2H3,(H,20,26)/t10-,17-/m0/s1
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n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Bioorg Med Chem Lett 6: 1303-1308 (1996)


Article DOI: 10.1016/0960-894X(96)00221-1
BindingDB Entry DOI: 10.7270/Q2V1259K
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50264087
PNG
((2S,2'S,3R,3'R,4S,4'S,5R,5'R)-2,2'-(4-(2,4-dihydro...)
Show SMILES O[C@@H]1CO[C@@H](Oc2ccc(CCc3ccc(O)cc3O)c(O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c2)[C@H](O)[C@H]1O
Show InChI InChI=1S/C24H30O12/c25-13-5-3-11(15(26)7-13)1-2-12-4-6-14(35-23-21(31)19(29)16(27)9-33-23)8-18(12)36-24-22(32)20(30)17(28)10-34-24/h3-8,16-17,19-32H,1-2,9-10H2/t16-,17-,19+,20+,21-,22-,23+,24+/m1/s1
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n/an/a 730n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50340787
PNG
(4-(beta-D-Glucopyranosyl)-2,2',4'-trihydroxybibenz...)
Show SMILES OC[C@H]1O[C@@H](Oc2ccc(CCc3ccc(O)cc3O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C20H24O9/c21-9-16-17(25)18(26)19(27)20(29-16)28-13-6-4-11(15(24)8-13)2-1-10-3-5-12(22)7-14(10)23/h3-8,16-27H,1-2,9H2/t16-,17-,18+,19-,20-/m1/s1
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n/an/a 770n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146414
PNG
((2S)-2-[(2S)-2-[(2S)-2-({[(5-hydroxy-4-oxo-4H-pyra...)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C38H35N5O10/c44-24-11-9-21(10-12-24)13-32(37(49)50)42-35(47)30(14-22-17-39-28-7-3-1-5-26(22)28)41-36(48)31(15-23-18-40-29-8-4-2-6-27(23)29)43-38(51)53-19-25-16-33(45)34(46)20-52-25/h1-12,16-18,20,30-32,39-40,44,46H,13-15,19H2,(H,41,48)(H,42,47)(H,43,51)(H,49,50)/t30-,31-,32-/m0/s1
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n/an/a 780n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Bioorg Med Chem Lett 14: 2843-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.046
BindingDB Entry DOI: 10.7270/Q2N015ZH
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50340789
PNG
(2,2',4'-Trihydroxy-4-(beta-D-maltopyranosyl)bibenz...)
Show SMILES OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C26H34O14/c27-9-17-19(32)20(33)22(35)26(38-17)40-24-18(10-28)39-25(23(36)21(24)34)37-14-6-4-12(16(31)8-14)2-1-11-3-5-13(29)7-15(11)30/h3-8,17-36H,1-2,9-10H2/t17-,18-,19-,20+,21-,22-,23-,24-,25-,26-/m1/s1
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n/an/a 830n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50251005
PNG
((2S)-5,7,2',4'-tetrahydroxyflavanone | (S)-2-(2,4-...)
Show SMILES Oc1ccc([C@@H]2CC(=O)c3c(O)cc(O)cc3O2)c(O)c1
Show InChI InChI=1S/C15H12O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-5,13,16-19H,6H2/t13-/m0/s1
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n/an/a 980n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50251005
PNG
((2S)-5,7,2',4'-tetrahydroxyflavanone | (S)-2-(2,4-...)
Show SMILES Oc1ccc([C@@H]2CC(=O)c3c(O)cc(O)cc3O2)c(O)c1
Show InChI InChI=1S/C15H12O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-5,13,16-19H,6H2/t13-/m0/s1
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n/an/a 980n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM7462
PNG
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
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n/an/a 1.00E+3n/an/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 mins


J Nat Prod 79: 281-92 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00877
BindingDB Entry DOI: 10.7270/Q20V8FPM
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50540075
PNG
(CHEMBL2078992)
Show SMILES COC(=O)CN1C(=O)N(CCCCN2CCN(CC2)c2ccccc2OC)C(C1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C33H38N4O5/c1-41-29-18-10-9-17-28(29)35-23-21-34(22-24-35)19-11-12-20-37-32(40)36(25-30(38)42-2)31(39)33(37,26-13-5-3-6-14-26)27-15-7-4-8-16-27/h3-10,13-18H,11-12,19-25H2,1-2H3
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n/an/a 1.07E+3n/an/an/an/an/an/a



College of Pharmacy and Gachon Institute of Pharmaceutical Science

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


Eur J Med Chem 164: 517-545 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.066
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50330795
PNG
(2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Show SMILES CC(C)c1ccc(O)c(=O)cc1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-3-5-9(11)10(12)6-4-8/h3-7H,1-2H3,(H,11,12)
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n/an/a 1.15E+3n/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometry


Bioorg Med Chem 22: 6193-200 (2014)


Article DOI: 10.1016/j.bmc.2014.08.027
BindingDB Entry DOI: 10.7270/Q2DV1MG2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50330795
PNG
(2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Show SMILES CC(C)c1ccc(O)c(=O)cc1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-3-5-9(11)10(12)6-4-8/h3-7H,1-2H3,(H,11,12)
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n/an/a 1.15E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human tyrosinase


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50330795
PNG
(2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Show SMILES CC(C)c1ccc(O)c(=O)cc1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-3-5-9(11)10(12)6-4-8/h3-7H,1-2H3,(H,11,12)
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n/an/a 1.15E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of human tyrosinase


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205807
PNG
(CHEMBL3978212)
Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1
Show InChI InChI=1S/C14H9NO5/c16-9-2-3-10-11(6-9)20-12(14(10)18)5-8-1-4-13(17)15(19)7-8/h1-7,16,19H/b12-5-
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n/an/a 1.50E+3n/an/an/an/an/an/a



King Khalid University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


Eur J Med Chem 166: 417-431 (2019)


Article DOI: 10.1016/j.ejmech.2019.01.078
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120802
PNG
(CHEMBL3100130)
Show SMILES C[C@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C22H34O13/c1-9(2-3-10-4-5-11(25)6-12(10)26)32-21-19(31)17(29)20(14(8-24)34-21)35-22-18(30)16(28)15(27)13(7-23)33-22/h4-6,9,13-31H,2-3,7-8H2,1H3/t9-,13-,14-,15-,16+,17-,18-,19-,20-,21-,22+/m1/s1
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n/an/a 1.51E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Bioorg Med Chem 23: 6650-8 (2015)


Article DOI: 10.1016/j.bmc.2015.09.014
BindingDB Entry DOI: 10.7270/Q2DR2X9W
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50264085
PNG
((2S,3R,4S,5R)-2-(2-(2,4-dihydroxyphenethyl)-5-hydr...)
Show SMILES O[C@@H]1CO[C@@H](Oc2cc(O)ccc2CCc2ccc(O)cc2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C19H22O8/c20-12-5-3-10(14(22)7-12)1-2-11-4-6-13(21)8-16(11)27-19-18(25)17(24)15(23)9-26-19/h3-8,15,17-25H,1-2,9H2/t15-,17+,18-,19+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50219502
PNG
(4-hydroxyphenyl beta-D-glucopyranoside | Arbutin |...)
Show SMILES OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
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n/an/a>1.60E+3n/an/an/an/an/an/a



Jamia Hamdard

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) assessed as reduction in melanin formation


Eur J Med Chem 171: 66-92 (2019)


Article DOI: 10.1016/j.ejmech.2019.03.021
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50193667
PNG
(2,4,3',5'-tetrahydroxybibenzyl | CHEMBL221291)
Show SMILES Oc1ccc(CCc2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C14H14O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h3-8,15-18H,1-2H2
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n/an/a 1.60E+3n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Bioorg Med Chem Lett 16: 5650-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.018
BindingDB Entry DOI: 10.7270/Q2348K00
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120803
PNG
(CHEMBL3100134)
Show SMILES C[C@H](CCc1ccc(O)cc1O)O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H22O7/c1-8(2-3-9-4-5-10(16)6-11(9)17)22-15-14(20)13(19)12(18)7-21-15/h4-6,8,12-20H,2-3,7H2,1H3/t8-,12-,13+,14-,15+/m1/s1
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n/an/a 1.72E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Bioorg Med Chem 23: 6650-8 (2015)


Article DOI: 10.1016/j.bmc.2015.09.014
BindingDB Entry DOI: 10.7270/Q2DR2X9W
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218211
PNG
(1'-(4-Methyl-benzyl)-[1,4']bipiperidinyl | CHEMBL3...)
Show SMILES Cc1ccc(CN2CCC(CC2)N2CCCCC2)cc1
Show InChI InChI=1S/C18H28N2/c1-16-5-7-17(8-6-16)15-19-13-9-18(10-14-19)20-11-3-2-4-12-20/h5-8,18H,2-4,9-15H2,1H3
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n/an/a 1.72E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120804
PNG
(CHEMBL3618459)
Show SMILES C[C@@H](O)CCc1ccc(O)cc1O
Show InChI InChI=1S/C10H14O3/c1-7(11)2-3-8-4-5-9(12)6-10(8)13/h4-7,11-13H,2-3H2,1H3/t7-/m1/s1
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n/an/a 1.78E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Bioorg Med Chem 23: 6650-8 (2015)


Article DOI: 10.1016/j.bmc.2015.09.014
BindingDB Entry DOI: 10.7270/Q2DR2X9W
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50240041
PNG
(1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263...)
Show SMILES NC(=S)Nc1ccccc1
Show InChI InChI=1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Chungnam National University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Bioorg Med Chem 18: 1555-62 (2010)


Article DOI: 10.1016/j.bmc.2010.01.005
BindingDB Entry DOI: 10.7270/Q23F4PQ7
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50174577
PNG
(CHEMBL3810334)
Show SMILES Oc1c[nH]c(COC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)cc1=O
Show InChI InChI=1S/C23H22N2O6/c26-20-12-18(24-13-21(20)27)15-30-22(28)19(11-16-7-3-1-4-8-16)25-23(29)31-14-17-9-5-2-6-10-17/h1-10,12-13,19,27H,11,14-15H2,(H,24,26)(H,25,29)/t19-/m0/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) assessed as reduction in monophenolase activity


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50174577
PNG
(CHEMBL3810334)
Show SMILES Oc1c[nH]c(COC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)cc1=O
Show InChI InChI=1S/C23H22N2O6/c26-20-12-18(24-13-21(20)27)15-30-22(28)19(11-16-7-3-1-4-8-16)25-23(29)31-14-17-9-5-2-6-10-17/h1-10,12-13,19,27H,11,14-15H2,(H,24,26)(H,25,29)/t19-/m0/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) assessed as reduction in monophenolase activity


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120800
PNG
(CHEMBL3618460)
Show SMILES C[C@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C22H34O13/c1-9(2-3-10-4-5-11(25)6-12(10)26)32-21-19(31)17(29)20(14(8-24)34-21)35-22-18(30)16(28)15(27)13(7-23)33-22/h4-6,9,13-31H,2-3,7-8H2,1H3/t9-,13-,14-,15-,16+,17-,18-,19-,20-,21-,22-/m1/s1
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n/an/a 1.98E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Bioorg Med Chem 23: 6650-8 (2015)


Article DOI: 10.1016/j.bmc.2015.09.014
BindingDB Entry DOI: 10.7270/Q2DR2X9W
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287124
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES CC(C)C[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C19H21NO10/c1-10(2)3-13(18(25)29-6-11-4-14(21)16(23)8-27-11)20-19(26)30-7-12-5-15(22)17(24)9-28-12/h4-5,8-10,13,23-24H,3,6-7H2,1-2H3,(H,20,26)/t13-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Bioorg Med Chem Lett 6: 1303-1308 (1996)


Article DOI: 10.1016/0960-894X(96)00221-1
BindingDB Entry DOI: 10.7270/Q2V1259K
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146413
PNG
(2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmeth...)
Show SMILES OC(=O)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1)C(O)=O
Show InChI InChI=1S/C31H30N4O11/c36-25-12-19(45-16-26(25)37)15-46-31(44)35-22(10-17-6-2-1-3-7-17)28(40)33-23(29(41)34-24(30(42)43)13-27(38)39)11-18-14-32-21-9-5-4-8-20(18)21/h1-9,12,14,16,22-24,32,37H,10-11,13,15H2,(H,33,40)(H,34,41)(H,35,44)(H,38,39)(H,42,43)/t22-,23-,24-/m0/s1
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n/an/a 2.13E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Bioorg Med Chem Lett 14: 2843-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.046
BindingDB Entry DOI: 10.7270/Q2N015ZH
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120813
PNG
(CHEMBL3618457)
Show SMILES C[C@H](O)CCc1ccc(O)cc1O
Show InChI InChI=1S/C10H14O3/c1-7(11)2-3-8-4-5-9(12)6-10(8)13/h4-7,11-13H,2-3H2,1H3/t7-/m0/s1
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n/an/a 2.17E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Bioorg Med Chem 23: 6650-8 (2015)


Article DOI: 10.1016/j.bmc.2015.09.014
BindingDB Entry DOI: 10.7270/Q2DR2X9W
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50146417
PNG
(2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmeth...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cc(=O)c(O)co1)C(O)=O
Show InChI InChI=1S/C33H36N4O9/c1-3-19(2)29(32(42)43)37-31(41)26(14-21-16-34-24-12-8-7-11-23(21)24)35-30(40)25(13-20-9-5-4-6-10-20)36-33(44)46-17-22-15-27(38)28(39)18-45-22/h4-12,15-16,18-19,25-26,29,34,39H,3,13-14,17H2,1-2H3,(H,35,40)(H,36,44)(H,37,41)(H,42,43)/t19-,25-,26-,29-/m0/s1
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n/an/a 2.18E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Bioorg Med Chem Lett 14: 2843-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.046
BindingDB Entry DOI: 10.7270/Q2N015ZH
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50120806
PNG
(CHEMBL3100132)
Show SMILES C[C@H](CCc1ccc(O)cc1O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C16H24O8/c1-8(2-3-9-4-5-10(18)6-11(9)19)23-16-15(22)14(21)13(20)12(7-17)24-16/h4-6,8,12-22H,2-3,7H2,1H3/t8-,12-,13-,14+,15-,16-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Bioorg Med Chem 23: 6650-8 (2015)


Article DOI: 10.1016/j.bmc.2015.09.014
BindingDB Entry DOI: 10.7270/Q2DR2X9W
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50139369
PNG
(2-Hydroxy-4-isopropyl-benzaldehyde | CHEMBL353354)
Show SMILES CC(C)c1ccc(C=O)c(O)c1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-3-4-9(6-11)10(12)5-8/h3-7,12H,1-2H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase


Bioorg Med Chem Lett 14: 681-3 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.033
BindingDB Entry DOI: 10.7270/Q27S7N6X
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50287123
PNG
((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Show SMILES CC(C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C18H19NO10/c1-9(2)16(17(24)28-5-10-3-12(20)14(22)7-26-10)19-18(25)29-6-11-4-13(21)15(23)8-27-11/h3-4,7-9,16,22-23H,5-6H2,1-2H3,(H,19,25)/t16-/m0/s1
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n/an/a 2.39E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Bioorg Med Chem Lett 6: 1303-1308 (1996)


Article DOI: 10.1016/0960-894X(96)00221-1
BindingDB Entry DOI: 10.7270/Q2V1259K
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50174577
PNG
(CHEMBL3810334)
Show SMILES Oc1c[nH]c(COC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)cc1=O
Show InChI InChI=1S/C23H22N2O6/c26-20-12-18(24-13-21(20)27)15-30-22(28)19(11-16-7-3-1-4-8-16)25-23(29)31-14-17-9-5-2-6-10-17/h1-10,12-13,19,27H,11,14-15H2,(H,24,26)(H,25,29)/t19-/m0/s1
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n/an/a 2.79E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) assessed as reduction in diphenolase activity


J Med Chem 61: 7395-7418 (2018)


Article DOI: 10.1021/acs.jmedchem.7b00967
More data for this
Ligand-Target Pair
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