TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 0.0500nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 0.300nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Inhibition of wild-type Bcr-Abl autophosphorylation (unknown origin) expressed in mouse BA/F3 cells for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nM EC50: <3nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Inhibition of wild-type Bcr-Abl autophosphorylation (unknown origin) expressed in mouse BA/F3 cells for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) expressed in mouse BAF3 cells assessed as inhibition of STAT5 phosphorylation after 1 hr by immun...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) expressed in mouse BAF3 cells assessed as inhibition of CrkL phosphorylation after 1 hr by immuno...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL in human MEG01 cells assessed as inhibition of BCR/ABL autophosphorylation at Y245 site after 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) expressed in mouse BAF3 cells assessed as inhibition of ErK phosphorylation after 1 hr by immunob...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) expressed in mouse BAF3 cells assessed as inhibition of BCR/ABL T315I mutant autophosphorylation ...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL in human K562 cells assessed as inhibition of BCR/ABL autophosphorylation at Y245 site after 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Antiproliferative activity against K562 cells expressing Bcr-AblMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Inhibition of NanoLuc-fused ABL1 (unknown origin) expressed in human HEK293 cells incubated for 2 to 3 mins by NanoBRET assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) autophosphorylation expressed in mouse BA/F3 cells for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 25nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) autophosphorylation expressed in mouse BA/F3 cells for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: <30nMAssay Description:Inhibition of BCR/ABL in human KU812 cells assessed as inhibition of BCR/ABL autophosphorylation at Y245 site after 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Antiproliferative activity against K562 cells expressing Bcr-AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 34nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 48nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 372nM EC50: 70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 70nMAssay Description:Antiproliferative activity against K562 cells expressing Bcr-AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 90nMAssay Description:Antiproliferative activity against K562 cells expressing Bcr-AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 90nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Induction of human c-ABL phosphorylation at Y245/Y412 residues in bacmam-induced HEK-MSR2 cell lysates by in-cell Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Induction of human c-ABL phosphorylation at Y245/Y412 residues in bacmam-induced HEK-MSR2 cell lysates by in-cell Western blot analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 120nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 140nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 140nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 150nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 160nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 160nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 170nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 240nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 250nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 270nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 290nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 300nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Induction of human c-ABL phosphorylation at Y245/Y412 residues in bacmam-induced HEK-MSR2 cell lysates by in-cell Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Induction of human c-ABL phosphorylation at Y245/Y412 residues in bacmam-induced HEK-MSR2 cell lysates by in-cell Western blot analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 330nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 330nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 340nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 350nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 360nMAssay Description:Antiproliferative activity against K562 cells expressing Bcr-AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 360nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair