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Found 252 of ic50 for UniProtKB: A0A024R0J1
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1nMAssay Description:Inhibition of protein kinase C epsilon expressed in Sf-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human PAK4 expressed in TR-293-KDG cells assessed as inhibition of GEFH1 phosphorylation at S180 using GEFH1 as substrate incubated for...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of recombinant human N-terminal GST-fused PAK4 (1 to 591 residues) expressed in baculovirus expression system using S2 as substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50600087(CHEMBL5180027)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50043014(CHEMBL3355023)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50591962(CHEMBL5175418)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of PAK4 (unknown origin) using S2 as substrate incubated for 60 mins in the presence of ATP by time-resolved HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataIC50:  7nMAssay Description:Inhibition of peptide substrate phosphorylation by epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50251098(CHEMBL4097816)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50442758(CHEMBL2443139)
Affinity DataIC50: >10nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50442759(CHEMBL2443138)
Affinity DataIC50: >10nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50442760(CHEMBL2443044)
Affinity DataIC50: >10nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50442757(CHEMBL2443026)
Affinity DataIC50: >10nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50251098(CHEMBL4097816)
Affinity DataIC50:  11nMAssay Description:Inhibition of GST-tagged human PAK4 (295 to 591 residues) expressed in Baculovirus expression system by Z'-Lyte assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50237832(CHEMBL1198335)
Affinity DataIC50:  15nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as reduction in histone phosphorylation incubated for 1 hr at 4 degC by immunoblotting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252687(CHEMBL4078441)
Affinity DataIC50:  16nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252687(CHEMBL4078441)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes after 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252687(CHEMBL4078441)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataIC50:  18nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged PAK4 expressed in bacterial expression system by pyruvate kinase/LDH enzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50:  19nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human PAK4 kinase domain (300 to 591) using peptide 7 as substrate by pyruvate kinase/lactate dehydr...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50600088(CHEMBL5183512)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human PAK4 using RRRLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252732(CHEMBL4104099)
Affinity DataIC50:  22nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252732(CHEMBL4104099)
Affinity DataIC50:  22nMAssay Description:Binding affinity to CK2alpha (unknown origin) by ITCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50449495(CHEMBL4160587)
Affinity DataIC50:  25nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252688(CHEMBL4088781)
Affinity DataIC50:  27nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  27.9nMAssay Description:Inhibition of human PAK4 using RRRLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252688(CHEMBL4088781)
Affinity DataIC50:  28nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50449511(CHEMBL4164650)
Affinity DataIC50:  32nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50237831(CHEMBL4087295)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant human N-terminal GST-fused PAK4 (1 to 591 residues) expressed in baculovirus expression system using S2 as substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50043013(CHEMBL3355024)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50:  38nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(CHEMBL3128043 | US8530494, 203 | US8530652, 114 | ...)
Affinity DataIC50:  38nMAssay Description:Inhibition of full length recombinant human N-terminal GST/His6-tagged PAK4 expressed in baculovirus infected sf9 insect cells using tetra LRRWSLG as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50:  46nMAssay Description:Inhibition of PAK4 kinase domain (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50600084(CHEMBL5184137)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252708(CHEMBL4073938)
Affinity DataIC50:  54nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50449507(CHEMBL4172279)
Affinity DataIC50:  61nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50449510(CHEMBL4175282)
Affinity DataIC50:  63nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50448775(CHEMBL3128055)
Affinity DataIC50:  66nMAssay Description:Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50449498(CHEMBL4171839)
Affinity DataIC50:  67nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50:  76nMAssay Description:Inhibition of human recombinant GST-tagged PAK4 catalytic domain (295 to 591 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50449501(CHEMBL4174013)
Affinity DataIC50:  89nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50237819(CHEMBL4089425)
Affinity DataIC50:  93nMAssay Description:Inhibition of recombinant human N-terminal GST-fused PAK4 (1 to 591 residues) expressed in baculovirus expression system using S2 as substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50591934(CHEMBL5209160)
Affinity DataIC50:  96nMAssay Description:Inhibition of PAK4 (unknown origin) incubated for 60 mins by time-resolved HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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