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Compile Data Set for Download or QSAR

Found 331 hits of ic50 data for polymerid = 612   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366080
PNG
(US9873693, Compound 3)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3ccc4ncnn4c3)c2=O)cc1F
Show InChI InChI=1S/C26H19F2N5O2/c27-22-8-6-18(12-23(22)28)14-32-10-2-5-21(26(32)35)25(34)29-13-17-3-1-4-19(11-17)20-7-9-24-30-16-31-33(24)15-20/h1-12,15-16H,13-14H2,(H,29,34)
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n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366081
PNG
(US9873693, Compound 4)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(n3)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C26H19F2N5O2/c27-21-9-8-16(12-22(21)28)15-33-11-3-6-19(26(33)35)25(34)31-13-17-4-1-7-23(32-17)20-14-30-24-18(20)5-2-10-29-24/h1-12,14H,13,15H2,(H,29,30)(H,31,34)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366082
PNG
(US9873693, Compound 5)
Show SMILES Nc1ncnc2[nH]nc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c12
Show InChI InChI=1S/C25H19F2N7O2/c26-18-7-6-15(10-19(18)27)12-34-8-2-5-17(25(34)36)24(35)29-11-14-3-1-4-16(9-14)21-20-22(28)30-13-31-23(20)33-32-21/h1-10,13H,11-12H2,(H,29,35)(H3,28,30,31,32,33)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366083
PNG
(US9873693, Compound 6)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3n[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C26H19F2N5O2/c27-21-9-8-17(13-22(21)28)15-33-11-3-7-20(26(33)35)25(34)30-14-16-4-1-5-18(12-16)23-19-6-2-10-29-24(19)32-31-23/h1-13H,14-15H2,(H,30,34)(H,29,31,32)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366084
PNG
(US9873693, Compound 7)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3ccc(s3)-c3n[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C24H17F2N5O2S/c25-18-7-5-14(11-19(18)26)13-31-10-2-4-17(24(31)33)23(32)28-12-15-6-8-20(34-15)21-16-3-1-9-27-22(16)30-29-21/h1-11H,12-13H2,(H,28,32)(H,27,29,30)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366085
PNG
(US9873693, Compound 225 | US9873693, Compound 8)
Show SMILES OCc1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C28H22F2N4O3/c29-24-7-6-18(11-25(24)30)15-34-8-2-5-21(28(34)37)27(36)33-12-17-3-1-4-20(9-17)23-14-32-26-22(23)10-19(16-35)13-31-26/h1-11,13-14,35H,12,15-16H2,(H,31,32)(H,33,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366086
PNG
(US9873693, Compound 336 | US9873693, Compound 9)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3ccc4nccn4c3)c2=O)cc1F
Show InChI InChI=1S/C27H20F2N4O2/c28-23-8-6-19(14-24(23)29)16-33-11-2-5-22(27(33)35)26(34)31-15-18-3-1-4-20(13-18)21-7-9-25-30-10-12-32(25)17-21/h1-14,17H,15-16H2,(H,31,34)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366087
PNG
(US9873693, Compound 10)
Show SMILES Fc1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C27H19F3N4O2/c28-19-11-21-22(14-32-25(21)31-13-19)18-4-1-3-16(9-18)12-33-26(35)20-5-2-8-34(27(20)36)15-17-6-7-23(29)24(30)10-17/h1-11,13-14H,12,15H2,(H,31,32)(H,33,35)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM365948
PNG
(US9873693, Compound 1)
Show SMILES Fc1ccc(Cn2cccc(C(=O)N[C@H]3CC[C@H](CC3)c3c[nH]c4ncccc34)c2=O)cc1F
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366079
PNG
(US9873693, Compound 2)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3ccc(s3)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C25H18F2N4O2S/c26-20-7-5-15(11-21(20)27)14-31-10-2-4-18(25(31)33)24(32)30-12-16-6-8-22(34-16)19-13-29-23-17(19)3-1-9-28-23/h1-11,13H,12,14H2,(H,28,29)(H,30,32)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366088
PNG
(US9873693, Compound 11)
Show SMILES Fc1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1
Show InChI InChI=1S/C25H17F3N4O2S/c26-15-9-18-19(12-30-23(18)29-10-15)22-6-4-16(35-22)11-31-24(33)17-2-1-7-32(25(17)34)13-14-3-5-20(27)21(28)8-14/h1-10,12H,11,13H2,(H,29,30)(H,31,33)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366089
PNG
(US9873693, Compound 12)
Show SMILES OCc1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1
Show InChI InChI=1S/C26H20F2N4O3S/c27-21-5-3-15(9-22(21)28)13-32-7-1-2-18(26(32)35)25(34)31-11-17-4-6-23(36-17)20-12-30-24-19(20)8-16(14-33)10-29-24/h1-10,12,33H,11,13-14H2,(H,29,30)(H,31,34)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366090
PNG
(US9873693, Compound 13)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4nccnc34)c2=O)cc1F
Show InChI InChI=1S/C26H19F2N5O2/c27-21-7-6-17(12-22(21)28)15-33-10-2-5-19(26(33)35)25(34)32-13-16-3-1-4-18(11-16)20-14-31-24-23(20)29-8-9-30-24/h1-12,14H,13,15H2,(H,30,31)(H,32,34)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366091
PNG
(US9873693, Compound 14)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3ccc(s3)-c3c[nH]c4nccnc34)c2=O)cc1F
Show InChI InChI=1S/C24H17F2N5O2S/c25-18-5-3-14(10-19(18)26)13-31-9-1-2-16(24(31)33)23(32)30-11-15-4-6-20(34-15)17-12-29-22-21(17)27-7-8-28-22/h1-10,12H,11,13H2,(H,28,29)(H,30,32)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366092
PNG
(US9873693, Compound 15 | US9873693, Compound 234)
Show SMILES OC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366093
PNG
(US9873693, Compound 16)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NC3CCCc4ccc(cc34)-c3c[nH]c4ncccc34)c2=O)cc1F
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366094
PNG
(US9873693, Compound 17)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cc(cs3)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C25H18F2N4O2S/c26-21-6-5-15(9-22(21)27)13-31-8-2-4-19(25(31)33)24(32)30-11-17-10-16(14-34-17)20-12-29-23-18(20)3-1-7-28-23/h1-10,12,14H,11,13H2,(H,28,29)(H,30,32)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366095
PNG
(US9873693, Compound 18)
Show SMILES CNC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366096
PNG
(US9873693, Compound 19)
Show SMILES NC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366097
PNG
(US9873693, Compound 20)
Show SMILES OC(=O)c1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C28H20F2N4O4/c29-23-7-6-17(10-24(23)30)15-34-8-2-5-20(27(34)36)26(35)33-12-16-3-1-4-18(9-16)22-14-32-25-21(22)11-19(13-31-25)28(37)38/h1-11,13-14H,12,15H2,(H,31,32)(H,33,35)(H,37,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366098
PNG
(US9873693, Compound 21)
Show SMILES OC(=O)c1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1
Show InChI InChI=1S/C26H18F2N4O4S/c27-20-5-3-14(8-21(20)28)13-32-7-1-2-17(25(32)34)24(33)31-11-16-4-6-22(37-16)19-12-30-23-18(19)9-15(10-29-23)26(35)36/h1-10,12H,11,13H2,(H,29,30)(H,31,33)(H,35,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366099
PNG
(US9873693, Compound 22)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(Cl)cc34)c2=O)cc1F
Show InChI InChI=1S/C27H19ClF2N4O2/c28-19-11-21-22(14-32-25(21)31-13-19)18-4-1-3-16(9-18)12-33-26(35)20-5-2-8-34(27(20)36)15-17-6-7-23(29)24(30)10-17/h1-11,13-14H,12,15H2,(H,31,32)(H,33,35)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366100
PNG
(US9873693, Compound 23)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3ccc(s3)-c3c[nH]c4ncc(Cl)cc34)c2=O)cc1F
Show InChI InChI=1S/C25H17ClF2N4O2S/c26-15-9-18-19(12-30-23(18)29-10-15)22-6-4-16(35-22)11-31-24(33)17-2-1-7-32(25(17)34)13-14-3-5-20(27)21(28)8-14/h1-10,12H,11,13H2,(H,29,30)(H,31,33)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366101
PNG
(US9873693, Compound 24)
Show SMILES NC(=O)C(NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366102
PNG
(US9873693, Compound 25)
Show SMILES CC(C)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C30H26F2N4O3/c1-18(2)39-22-12-20(11-21(14-22)25-16-34-28-23(25)5-3-9-33-28)15-35-29(37)24-6-4-10-36(30(24)38)17-19-7-8-26(31)27(32)13-19/h3-14,16,18H,15,17H2,1-2H3,(H,33,34)(H,35,37)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366103
PNG
(US9873693, Compound 26)
Show SMILES NC(=O)c1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C28H21F2N5O3/c29-23-7-6-17(10-24(23)30)15-35-8-2-5-20(28(35)38)27(37)34-12-16-3-1-4-18(9-16)22-14-33-26-21(22)11-19(13-32-26)25(31)36/h1-11,13-14H,12,15H2,(H2,31,36)(H,32,33)(H,34,37)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366104
PNG
(US9873693, Compound 27)
Show SMILES CN(C)C(=O)c1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C30H25F2N5O3/c1-36(2)29(39)21-13-23-24(16-34-27(23)33-15-21)20-6-3-5-18(11-20)14-35-28(38)22-7-4-10-37(30(22)40)17-19-8-9-25(31)26(32)12-19/h3-13,15-16H,14,17H2,1-2H3,(H,33,34)(H,35,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366105
PNG
(US9873693, Compound 28)
Show SMILES CCNC(=O)c1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C30H25F2N5O3/c1-2-33-28(38)21-13-23-24(16-35-27(23)34-15-21)20-6-3-5-18(11-20)14-36-29(39)22-7-4-10-37(30(22)40)17-19-8-9-25(31)26(32)12-19/h3-13,15-16H,2,14,17H2,1H3,(H,33,38)(H,34,35)(H,36,39)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366106
PNG
(US9873693, Compound 29)
Show SMILES CCCNC(=O)c1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C31H27F2N5O3/c1-2-10-34-29(39)22-14-24-25(17-36-28(24)35-16-22)21-6-3-5-19(12-21)15-37-30(40)23-7-4-11-38(31(23)41)18-20-8-9-26(32)27(33)13-20/h3-9,11-14,16-17H,2,10,15,18H2,1H3,(H,34,39)(H,35,36)(H,37,40)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366107
PNG
(US9873693, Compound 30)
Show SMILES COCCNC(=O)c1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C31H27F2N5O4/c1-42-11-9-34-29(39)22-14-24-25(17-36-28(24)35-16-22)21-5-2-4-19(12-21)15-37-30(40)23-6-3-10-38(31(23)41)18-20-7-8-26(32)27(33)13-20/h2-8,10,12-14,16-17H,9,11,15,18H2,1H3,(H,34,39)(H,35,36)(H,37,40)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366108
PNG
(US9873693, Compound 31)
Show SMILES CCNC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366109
PNG
(US9873693, Compound 32)
Show SMILES CCCNC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366110
PNG
(US9873693, Compound 33)
Show SMILES Fc1ccc(Cn2cccc(C(=O)N[C@H](CC(=O)NC3CC3)c3ccc(s3)-c3c[nH]c4ncccc34)c2=O)cc1F
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366111
PNG
(US9873693, Compound 34)
Show SMILES COCCNC(=O)C[C@@H](NC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)c1ccc(s1)-c1c[nH]c2ncccc12
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366112
PNG
(US9873693, Compound 35)
Show SMILES Fc1ccc(Cn2cccc(C(=O)Nc3cccc4ccc(cc34)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C30H20F2N4O2/c31-25-11-8-18(14-26(25)32)17-36-13-3-6-22(30(36)38)29(37)35-27-7-1-4-19-9-10-20(15-23(19)27)24-16-34-28-21(24)5-2-12-33-28/h1-16H,17H2,(H,33,34)(H,35,37)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366113
PNG
(US9873693, Compound 36)
Show SMILES C[Si](C)(C)CCOCn1nc(NC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)c2cc(ccc12)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C33H32F2N6O3Si/c1-45(2,3)15-14-44-20-41-29-11-9-22(26-18-37-30-23(26)6-4-12-36-30)17-25(29)31(39-41)38-32(42)24-7-5-13-40(33(24)43)19-21-8-10-27(34)28(35)16-21/h4-13,16-18H,14-15,19-20H2,1-3H3,(H,36,37)(H,38,39,42)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366114
PNG
(US9873693, Compound 243 | US9873693, Compound 37)
Show SMILES NCc1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1
Show InChI InChI=1S/C28H23F2N5O2/c29-24-7-6-18(11-25(24)30)16-35-8-2-5-21(28(35)37)27(36)34-13-17-3-1-4-20(9-17)23-15-33-26-22(23)10-19(12-31)14-32-26/h1-11,14-15H,12-13,16,31H2,(H,32,33)(H,34,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366115
PNG
(US9873693, Compound 244 | US9873693, Compound 38)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)C#N)c2=O)cc1F
Show InChI InChI=1S/C28H19F2N5O2/c29-24-7-6-18(11-25(24)30)16-35-8-2-5-21(28(35)37)27(36)34-13-17-3-1-4-20(9-17)23-15-33-26-22(23)10-19(12-31)14-32-26/h1-11,14-15H,13,16H2,(H,32,33)(H,34,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366116
PNG
(US9873693, Compound 39)
Show SMILES NC(=O)c1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1
Show InChI InChI=1S/C26H19F2N5O3S/c27-20-5-3-14(8-21(20)28)13-33-7-1-2-17(26(33)36)25(35)32-11-16-4-6-22(37-16)19-12-31-24-18(19)9-15(10-30-24)23(29)34/h1-10,12H,11,13H2,(H2,29,34)(H,30,31)(H,32,35)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366117
PNG
(US9873693, Compound 40)
Show SMILES CNC(=O)c1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1
Show InChI InChI=1S/C27H21F2N5O3S/c1-30-25(35)16-10-19-20(13-32-24(19)31-11-16)23-7-5-17(38-23)12-33-26(36)18-3-2-8-34(27(18)37)14-15-4-6-21(28)22(29)9-15/h2-11,13H,12,14H2,1H3,(H,30,35)(H,31,32)(H,33,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366118
PNG
(US9873693, Compound 41)
Show SMILES CCNC(=O)c1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1
Show InChI InChI=1S/C28H23F2N5O3S/c1-2-31-26(36)17-11-20-21(14-33-25(20)32-12-17)24-8-6-18(39-24)13-34-27(37)19-4-3-9-35(28(19)38)15-16-5-7-22(29)23(30)10-16/h3-12,14H,2,13,15H2,1H3,(H,31,36)(H,32,33)(H,34,37)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366119
PNG
(US9873693, Compound 245 | US9873693, Compound 42)
Show SMILES Fc1ccc(Cn2cccc(C(=O)Nc3n[nH]c4ccc(cc34)-c3c[nH]c4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C27H18F2N6O2/c28-21-7-5-15(11-22(21)29)14-35-10-2-4-18(27(35)37)26(36)32-25-19-12-16(6-8-23(19)33-34-25)20-13-31-24-17(20)3-1-9-30-24/h1-13H,14H2,(H,30,31)(H2,32,33,34,36)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366120
PNG
(US9873693, Compound 246 | US9873693, Compound 43)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3nnn[nH]3)c2=O)cc1F
Show InChI InChI=1S/C28H20F2N8O2/c29-23-7-6-17(10-24(23)30)15-38-8-2-5-20(28(38)40)27(39)33-12-16-3-1-4-18(9-16)22-14-32-26-21(22)11-19(13-31-26)25-34-36-37-35-25/h1-11,13-14H,12,15H2,(H,31,32)(H,33,39)(H,34,35,36,37)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366121
PNG
(US9873693, Compound 44)
Show SMILES Fc1ccc(Cn2cccc(NC(=O)Cc3cccc(c3)C3CNc4ncccc34)c2=O)cc1F
Show InChI InChI=1S/C27H22F2N4O2/c28-22-9-8-18(13-23(22)29)16-33-11-3-7-24(27(33)35)32-25(34)14-17-4-1-5-19(12-17)21-15-31-26-20(21)6-2-10-30-26/h1-13,21H,14-16H2,(H,30,31)(H,32,34)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366122
PNG
(US9873693, Compound 330 | US9873693, Compound 45)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(Br)cc34)c2=O)cc1F
Show InChI InChI=1S/C27H19BrF2N4O2/c28-19-11-21-22(14-32-25(21)31-13-19)18-4-1-3-16(9-18)12-33-26(35)20-5-2-8-34(27(20)36)15-17-6-7-23(29)24(30)10-17/h1-11,13-14H,12,15H2,(H,31,32)(H,33,35)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366123
PNG
(US9873693, Compound 331 | US9873693, Compound 46)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3ccsc3)c2=O)cc1F
Show InChI InChI=1S/C31H22F2N4O2S/c32-27-7-6-20(12-28(27)33)17-37-9-2-5-24(31(37)39)30(38)36-14-19-3-1-4-21(11-19)26-16-35-29-25(26)13-23(15-34-29)22-8-10-40-18-22/h1-13,15-16,18H,14,17H2,(H,34,35)(H,36,38)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366124
PNG
(US9873693, Compound 332 | US9873693, Compound 47)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3cccnc3)c2=O)cc1F
Show InChI InChI=1S/C32H23F2N5O2/c33-28-9-8-21(13-29(28)34)19-39-11-3-7-25(32(39)41)31(40)38-15-20-4-1-5-22(12-20)27-18-37-30-26(27)14-24(17-36-30)23-6-2-10-35-16-23/h1-14,16-18H,15,19H2,(H,36,37)(H,38,40)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366125
PNG
(US9873693, Compound 333 | US9873693, Compound 48)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3ccncc3)c2=O)cc1F
Show InChI InChI=1S/C32H23F2N5O2/c33-28-7-6-21(14-29(28)34)19-39-12-2-5-25(32(39)41)31(40)38-16-20-3-1-4-23(13-20)27-18-37-30-26(27)15-24(17-36-30)22-8-10-35-11-9-22/h1-15,17-18H,16,19H2,(H,36,37)(H,38,40)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366126
PNG
(US9873693, Compound 49)
Show SMILES Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C27H20F2N4O3/c28-23-6-5-16(11-24(23)29)15-33-8-2-4-21(27(33)36)26(35)32-13-17-9-18(12-19(34)10-17)22-14-31-25-20(22)3-1-7-30-25/h1-12,14,34H,13,15H2,(H,30,31)(H,32,35)
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Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (PDK1)


(Homo sapiens (Human))
BDBM366127
PNG
(US9873693, Compound 50)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4nccc(Cl)c34)c2=O)cc1F
Show InChI InChI=1S/C27H19ClF2N4O2/c28-21-8-9-31-25-24(21)20(14-32-25)18-4-1-3-16(11-18)13-33-26(35)19-5-2-10-34(27(19)36)15-17-6-7-22(29)23(30)12-17/h1-12,14H,13,15H2,(H,31,32)(H,33,35)
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PC sid
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US Patent
n/an/a<500n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc

US Patent


Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...


US Patent US9873693 (2018)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair
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