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Compile Data Set for Download or QSAR

Found 78 hits of kd for UniProtKB: O95931   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50538810
PNG
(CHEMBL4647581)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C73H86BrN11O15S/c1-41(2)34-57(69(95)79-55(64(75)90)16-10-12-32-76-73(101)78-47-24-29-51(54(37-47)72(98)99)63-52-30-27-49(88)38-61(52)100-62-39-50(89)28-31-53(62)63)83-71(97)60(40-86)84-67(93)56(17-11-13-33-85(4,5)6)80-70(96)59(36-44-18-25-48(87)26-19-44)81-65(91)42(3)77-68(94)58(35-43-14-8-7-9-15-43)82-66(92)45-20-22-46(74)23-21-45/h7-9,14-15,18-31,37-39,41-42,55-60,86H,10-13,16-17,32-36,40H2,1-6H3,(H13-,75,76,77,78,79,80,81,82,83,84,87,88,89,90,91,92,93,94,95,96,97,98,99,101)/p+1/t42-,55-,56-,57-,58-,59-,60-/m0/s1
PDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC cid
PC sid
UniChem
PubMed
n/an/an/a 11n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50155931
PNG
(CHEMBL3780251)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C72H82BrN11O17S/c1-40(76-68(96)56(34-41-12-6-5-7-13-41)82-65(93)43-18-20-44(73)21-19-43)64(92)81-57(35-42-16-23-46(86)24-17-42)69(97)79-54(15-9-11-33-84(2,3)4)66(94)83-58(39-85)70(98)80-55(30-31-61(89)90)67(95)78-53(63(74)91)14-8-10-32-75-72(102)77-45-22-27-49(52(36-45)71(99)100)62-50-28-25-47(87)37-59(50)101-60-38-48(88)26-29-51(60)62/h5-7,12-13,16-29,36-38,40,53-58,85H,8-11,14-15,30-35,39H2,1-4H3,(H14-,74,75,76,77,78,79,80,81,82,83,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,102)/p+1/t40-,53-,54-,55-,56-,57-,58-/m0/s1
PDB

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PubMed
n/an/an/a 12n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50194259
PNG
(CHEMBL3939958)
Show SMILES CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)OC
Show InChI InChI=1S/C43H66N6O8/c1-10-49(11-2)24-16-15-19-33(39(53)48-36(27-50)42(56)57-9)45-41(55)34(25-28(3)4)46-37(51)29(5)44-40(54)35(26-30-17-13-12-14-18-30)47-38(52)31-20-22-32(23-21-31)43(6,7)8/h12-14,17-18,20-23,28-29,33-36,50H,10-11,15-16,19,24-27H2,1-9H3,(H,44,54)(H,45,55)(H,46,51)(H,47,52)(H,48,53)/t29-,33-,34-,35-,36-/m0/s1
PDB

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PubMed
n/an/an/a 97n/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Binding affinity to human C-terminal His-tagged CBX7 chromodomain (8 to 62 residues) expressed in Escherichia coli Rosetta BL21(DE3)pLysS by ITC meth...


J Med Chem 59: 8913-8923 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00801
BindingDB Entry DOI: 10.7270/Q2H1340D
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50519512
PNG
(CHEMBL4449240)
Show SMILES CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)OC
Show InChI InChI=1S/C37H62N6O8/c1-11-43(12-2)20-14-13-15-28(34(48)42-30(22-44)36(50)51-10)40-35(49)29(21-23(3)4)41-32(46)25(6)38-31(45)24(5)39-33(47)26-16-18-27(19-17-26)37(7,8)9/h16-19,23-25,28-30,44H,11-15,20-22H2,1-10H3,(H,38,45)(H,39,47)(H,40,49)(H,41,46)(H,42,48)/t24-,25-,28-,29-,30-/m0/s1
PDB

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UniProtKB/SwissProt
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antibodypedia
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PC sid
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Article
PubMed
n/an/an/a 97n/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of CBX7 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry


J Med Chem 62: 8996-9007 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00522
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50194259
PNG
(CHEMBL3939958)
Show SMILES CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)OC
Show InChI InChI=1S/C43H66N6O8/c1-10-49(11-2)24-16-15-19-33(39(53)48-36(27-50)42(56)57-9)45-41(55)34(25-28(3)4)46-37(51)29(5)44-40(54)35(26-30-17-13-12-14-18-30)47-38(52)31-20-22-32(23-21-31)43(6,7)8/h12-14,17-18,20-23,28-29,33-36,50H,10-11,15-16,19,24-27H2,1-9H3,(H,44,54)(H,45,55)(H,46,51)(H,47,52)(H,48,53)/t29-,33-,34-,35-,36-/m0/s1
PDB

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UniProtKB/SwissProt
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antibodypedia
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PC sid
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Article
PubMed
n/an/an/a 97n/an/an/an/an/a



University of Connecticut

Curated by ChEMBL


Assay Description
Binding affinity to Cbx7 (unknown origin) by ITC method


Eur J Med Chem 136: 14-35 (2017)


Article DOI: 10.1016/j.ejmech.2017.04.047
BindingDB Entry DOI: 10.7270/Q2F76G3G
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50155931
PNG
(CHEMBL3780251)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C72H82BrN11O17S/c1-40(76-68(96)56(34-41-12-6-5-7-13-41)82-65(93)43-18-20-44(73)21-19-43)64(92)81-57(35-42-16-23-46(86)24-17-42)69(97)79-54(15-9-11-33-84(2,3)4)66(94)83-58(39-85)70(98)80-55(30-31-61(89)90)67(95)78-53(63(74)91)14-8-10-32-75-72(102)77-45-22-27-49(52(36-45)71(99)100)62-50-28-25-47(87)37-59(50)101-60-38-48(88)26-29-51(60)62/h5-7,12-13,16-29,36-38,40,53-58,85H,8-11,14-15,30-35,39H2,1-4H3,(H14-,74,75,76,77,78,79,80,81,82,83,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,102)/p+1/t40-,53-,54-,55-,56-,57-,58-/m0/s1
PDB

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PC sid
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Article
PubMed
n/an/an/a 100n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged human CBX7 (8 to 62) expressed in Escherichia coli BL21 using FITC-peptide-3 as competitive binding probe ...


ACS Med Chem Lett 7: 139-44 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00378
BindingDB Entry DOI: 10.7270/Q2222WNZ
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50538812
PNG
(CHEMBL4635096)
Show SMILES CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](C1CCCC1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C71H86BrN11O16S/c1-5-51(76-67(94)55(35-40-15-7-6-8-16-40)80-63(90)42-21-23-43(72)24-22-42)64(91)82-61(41-17-9-10-18-41)69(96)79-53(20-12-14-34-83(2,3)4)65(92)81-56(39-84)68(95)78-54(31-32-59(87)88)66(93)77-52(62(73)89)19-11-13-33-74-71(100)75-44-25-28-47(50(36-44)70(97)98)60-48-29-26-45(85)37-57(48)99-58-38-46(86)27-30-49(58)60/h6-8,15-16,21-30,36-38,41,51-56,61,84H,5,9-14,17-20,31-35,39H2,1-4H3,(H13-,73,74,75,76,77,78,79,80,81,82,85,86,87,88,89,90,91,92,93,94,95,96,97,98,100)/p+1/t51-,52-,53-,54-,55-,56-,61-/m0/s1
PDB

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PubMed
n/an/an/a 160n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50157395
PNG
(CHEMBL3780663)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)C(N)=O
Show InChI InChI=1S/C61H85BrN12O14S/c1-36(65-58(85)45(32-37-14-6-5-7-15-37)70-55(82)39-22-24-40(62)25-23-39)54(81)69-46(33-38-20-26-41(76)27-21-38)59(86)67-43(17-11-13-31-74(2,3)4)56(83)71-47(34-75)60(87)68-44(28-29-51(78)79)57(84)66-42(53(63)80)16-10-12-30-64-50(77)19-9-8-18-49-52-48(35-89-49)72-61(88)73-52/h5-7,14-15,20-27,36,42-49,52,75H,8-13,16-19,28-35H2,1-4H3,(H13-,63,64,65,66,67,68,69,70,71,72,73,76,77,78,79,80,81,82,83,84,85,86,87,88)/p+1/t36-,42-,43-,44-,45-,46-,47-,48-,49-,52-/m0/s1
PDB

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Article
PubMed
n/an/an/a 160n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged human CBX7 (8 to 62 residues) expressed in Escherichia coli BL21 by surface plasmon resonance assay


ACS Med Chem Lett 7: 139-44 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00378
BindingDB Entry DOI: 10.7270/Q2222WNZ
More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM50009554
PNG
(CHEMBL3234442)
Show SMILES COC(=O)c1ccc(cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@H](CO)C(N)=O
Show InChI InChI=1S/C40H57N7O9/c1-25(42-38(53)31(23-26-13-7-6-8-14-26)44-36(51)28-18-20-29(21-19-28)40(55)56-5)35(50)46-33(27-15-9-10-16-27)39(54)43-30(17-11-12-22-47(2,3)4)37(52)45-32(24-48)34(41)49/h6-8,13-14,18-21,25,27,30-33,48H,9-12,15-17,22-24H2,1-5H3,(H6-,41,42,43,44,45,46,49,50,51,52,53,54)/p+1/t25-,30-,31-,32+,33-/m0/s1
PDB

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antibodypedia
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CHEMBL
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PC sid
UniChem

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Article
PubMed
n/an/an/a 200n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay


J Med Chem 57: 2874-83 (2014)


Article DOI: 10.1021/jm401487x
BindingDB Entry DOI: 10.7270/Q2571DJ3
More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM50009555
PNG
(CHEMBL3234443)
Show SMILES COC(=O)c1ccc(cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)NC(CO)CO
Show InChI InChI=1S/C40H58N6O9/c1-26(41-38(52)33(23-27-13-7-6-8-14-27)44-36(50)29-18-20-30(21-19-29)40(54)55-5)35(49)45-34(28-15-9-10-16-28)39(53)43-32(17-11-12-22-46(2,3)4)37(51)42-31(24-47)25-48/h6-8,13-14,18-21,26,28,31-34,47-48H,9-12,15-17,22-25H2,1-5H3,(H4-,41,42,43,44,45,49,50,51,52,53)/p+1/t26-,32-,33-,34-/m0/s1
PDB

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Article
PubMed
n/an/an/a 200n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay


J Med Chem 57: 2874-83 (2014)


Article DOI: 10.1021/jm401487x
BindingDB Entry DOI: 10.7270/Q2571DJ3
More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM50009553
PNG
(CHEMBL3234441)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](C1CCCC1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)NCC[NH3+]
Show InChI InChI=1S/C37H54BrN7O5/c1-25(41-36(49)31(24-26-12-6-5-7-13-26)43-34(47)28-17-19-29(38)20-18-28)33(46)44-32(27-14-8-9-15-27)37(50)42-30(35(48)40-22-21-39)16-10-11-23-45(2,3)4/h5-7,12-13,17-20,25,27,30-32H,8-11,14-16,21-24,39H2,1-4H3,(H4-,40,41,42,43,44,46,47,48,49,50)/p+2/t25-,30-,31-,32-/m0/s1
PDB

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Article
PubMed
n/an/an/a 220n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay


J Med Chem 57: 2874-83 (2014)


Article DOI: 10.1021/jm401487x
BindingDB Entry DOI: 10.7270/Q2571DJ3
More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM50009510
PNG
(CHEMBL3234188)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C37H54BrN7O7/c1-23(2)20-29(37(52)41-28(14-10-11-19-45(4,5)6)35(50)44-31(22-46)32(39)47)42-33(48)24(3)40-36(51)30(21-25-12-8-7-9-13-25)43-34(49)26-15-17-27(38)18-16-26/h7-9,12-13,15-18,23-24,28-31,46H,10-11,14,19-22H2,1-6H3,(H6-,39,40,41,42,43,44,47,48,49,50,51,52)/p+1/t24-,28-,29-,30-,31-/m0/s1
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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CHEMBL
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 280n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay


J Med Chem 57: 2874-83 (2014)


Article DOI: 10.1021/jm401487x
BindingDB Entry DOI: 10.7270/Q2571DJ3
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50157395
PNG
(CHEMBL3780663)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)C(N)=O
Show InChI InChI=1S/C61H85BrN12O14S/c1-36(65-58(85)45(32-37-14-6-5-7-15-37)70-55(82)39-22-24-40(62)25-23-39)54(81)69-46(33-38-20-26-41(76)27-21-38)59(86)67-43(17-11-13-31-74(2,3)4)56(83)71-47(34-75)60(87)68-44(28-29-51(78)79)57(84)66-42(53(63)80)16-10-12-30-64-50(77)19-9-8-18-49-52-48(35-89-49)72-61(88)73-52/h5-7,14-15,20-27,36,42-49,52,75H,8-13,16-19,28-35H2,1-4H3,(H13-,63,64,65,66,67,68,69,70,71,72,73,76,77,78,79,80,81,82,83,84,85,86,87,88)/p+1/t36-,42-,43-,44-,45-,46-,47-,48-,49-,52-/m0/s1
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n/an/an/a 290n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to human CBX7 V13A mutant expressed in Escherichia coli BL21 by surface plasmon resonance assay


ACS Med Chem Lett 7: 139-44 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00378
BindingDB Entry DOI: 10.7270/Q2222WNZ
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50538811
PNG
(CHEMBL4640223)
Show SMILES CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C73H84BrN11O16S/c1-5-53(78-69(96)57(36-42-16-8-6-9-17-42)82-65(92)44-22-24-45(74)25-23-44)66(93)83-58(37-43-18-10-7-11-19-43)70(97)80-55(21-13-15-35-85(2,3)4)67(94)84-59(41-86)71(98)81-56(32-33-62(89)90)68(95)79-54(64(75)91)20-12-14-34-76-73(102)77-46-26-29-49(52(38-46)72(99)100)63-50-30-27-47(87)39-60(50)101-61-40-48(88)28-31-51(61)63/h6-11,16-19,22-31,38-40,53-59,86H,5,12-15,20-21,32-37,41H2,1-4H3,(H13-,75,76,77,78,79,80,81,82,83,84,87,88,89,90,91,92,93,94,95,96,97,98,99,100,102)/p+1/t53-,54-,55-,56-,57-,58-,59-/m0/s1
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n/an/an/a 300n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50155893
PNG
(CHEMBL3780712)
Show SMILES CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C73H84BrN11O17S/c1-5-53(78-69(97)57(35-41-13-7-6-8-14-41)82-65(93)43-19-21-44(74)22-20-43)66(94)83-58(36-42-17-24-46(87)25-18-42)70(98)80-55(16-10-12-34-85(2,3)4)67(95)84-59(40-86)71(99)81-56(31-32-62(90)91)68(96)79-54(64(75)92)15-9-11-33-76-73(103)77-45-23-28-49(52(37-45)72(100)101)63-50-29-26-47(88)38-60(50)102-61-39-48(89)27-30-51(61)63/h6-8,13-14,17-30,37-39,53-59,86H,5,9-12,15-16,31-36,40H2,1-4H3,(H14-,75,76,77,78,79,80,81,82,83,84,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,103)/p+1/t53-,54-,55-,56-,57-,58-,59-/m0/s1
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n/an/an/a 400n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged human CBX7 (8 to 62) expressed in Escherichia coli BL21 using FITC-peptide-3 as competitive binding probe ...


ACS Med Chem Lett 7: 139-44 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00378
BindingDB Entry DOI: 10.7270/Q2222WNZ
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50538808
PNG
(CHEMBL4646516)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C54H67N9O12S/c1-30(2)24-41(52(72)60-40(14-10-11-23-63(4,5)6)50(70)62-43(29-64)48(55)68)61-49(69)31(3)57-51(71)42(25-32-12-8-7-9-13-32)59-46(67)21-22-56-54(76)58-33-15-18-36(39(26-33)53(73)74)47-37-19-16-34(65)27-44(37)75-45-28-35(66)17-20-38(45)47/h7-9,12-13,15-20,26-28,30-31,40-43,64H,10-11,14,21-25,29H2,1-6H3,(H10-,55,56,57,58,59,60,61,62,65,66,67,68,69,70,71,72,73,74,76)/p+1/t31-,40-,41-,42-,43-/m0/s1
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n/an/an/a 700n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50538814
PNG
(CHEMBL4640186)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C73H92N12O17S/c1-41(2)34-56(82-65(93)42(3)76-68(96)58(36-45-20-12-9-13-21-45)83-70(98)57(77-43(4)87)35-44-18-10-8-11-19-44)69(97)80-54(23-15-17-33-85(5,6)7)66(94)84-59(40-86)71(99)81-55(30-31-62(90)91)67(95)79-53(64(74)92)22-14-16-32-75-73(103)78-46-24-27-49(52(37-46)72(100)101)63-50-28-25-47(88)38-60(50)102-61-39-48(89)26-29-51(61)63/h8-13,18-21,24-29,37-39,41-42,53-59,86H,14-17,22-23,30-36,40H2,1-7H3,(H14-,74,75,76,77,78,79,80,81,82,83,84,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,103)/p+1/t42-,53-,54-,55-,56-,57-,58-,59-/m0/s1
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n/an/an/a 1.50E+3n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50538813
PNG
(CHEMBL4643012)
Show SMILES CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C1CCCC1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C75H94N12O17S/c1-6-54(80-71(99)59(38-45-21-11-8-12-22-45)84-70(98)58(78-43(2)89)37-44-19-9-7-10-20-44)67(95)86-65(46-23-13-14-24-46)73(101)83-56(26-16-18-36-87(3,4)5)68(96)85-60(42-88)72(100)82-57(33-34-63(92)93)69(97)81-55(66(76)94)25-15-17-35-77-75(105)79-47-27-30-50(53(39-47)74(102)103)64-51-31-28-48(90)40-61(51)104-62-41-49(91)29-32-52(62)64/h7-12,19-22,27-32,39-41,46,54-60,65,88H,6,13-18,23-26,33-38,42H2,1-5H3,(H14-,76,77,78,79,80,81,82,83,84,85,86,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,105)/p+1/t54-,55-,56-,57-,58-,59-,60-,65-/m0/s1
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n/an/an/a 1.50E+3n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50538809
PNG
(CHEMBL4637043)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C63H76N10O13S/c1-36(2)29-48(60(82)69-47(19-13-14-28-73(4,5)6)58(80)72-51(35-74)56(64)78)70-57(79)37(3)66-59(81)50(31-39-17-11-8-12-18-39)71-61(83)49(30-38-15-9-7-10-16-38)68-54(77)26-27-65-63(87)67-40-20-23-43(46(32-40)62(84)85)55-44-24-21-41(75)33-52(44)86-53-34-42(76)22-25-45(53)55/h7-12,15-18,20-25,32-34,36-37,47-51,74H,13-14,19,26-31,35H2,1-6H3,(H11-,64,65,66,67,68,69,70,71,72,75,76,77,78,79,80,81,82,83,84,85,87)/p+1/t37-,47-,48-,49-,50-,51-/m0/s1
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n/an/an/a 1.60E+3n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM50009463
PNG
(CHEMBL3234145)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C35H51N7O8/c1-22(37-34(49)28(38-23(2)44)19-24-11-7-6-8-12-24)32(47)40-29(20-25-14-16-26(45)17-15-25)35(50)39-27(13-9-10-18-42(3,4)5)33(48)41-30(21-43)31(36)46/h6-8,11-12,14-17,22,27-30,43H,9-10,13,18-21H2,1-5H3,(H7-,36,37,38,39,40,41,44,45,46,47,48,49,50)/p+1/t22-,27-,28-,29-,30-/m0/s1
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n/an/an/a 1.77E+3n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay


J Med Chem 57: 2874-83 (2014)


Article DOI: 10.1021/jm401487x
BindingDB Entry DOI: 10.7270/Q2571DJ3
More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM50009454
PNG
(CHEMBL3234136)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C32H53N7O7/c1-20(2)17-25(32(46)36-24(15-11-12-16-39(5,6)7)30(44)38-27(19-40)28(33)42)37-29(43)21(3)34-31(45)26(35-22(4)41)18-23-13-9-8-10-14-23/h8-10,13-14,20-21,24-27,40H,11-12,15-19H2,1-7H3,(H6-,33,34,35,36,37,38,41,42,43,44,45,46)/p+1/t21-,24-,25-,26-,27-/m0/s1
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n/an/an/a 2.00E+3n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay


J Med Chem 57: 2874-83 (2014)


Article DOI: 10.1021/jm401487x
BindingDB Entry DOI: 10.7270/Q2571DJ3
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515920
PNG
(CHEMBL4588523)
Show SMILES CN1C(=O)C(O)(CC(=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C21H17NO3/c1-22-18-12-5-4-11-17(18)21(25,20(22)24)13-19(23)16-10-6-8-14-7-2-3-9-15(14)16/h2-12,25H,13H2,1H3
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n/an/an/a 2.40E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515933
PNG
(CHEMBL4469115)
Show SMILES CCN(CC)C1CCN(CC1)C(=O)Cn1c2cc(F)ccc2oc1=O
Show InChI InChI=1S/C18H24FN3O3/c1-3-20(4-2)14-7-9-21(10-8-14)17(23)12-22-15-11-13(19)5-6-16(15)25-18(22)24/h5-6,11,14H,3-4,7-10,12H2,1-2H3
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n/an/an/a 2.80E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515938
PNG
(CHEMBL4473110)
Show SMILES COc1cccc(c1)C(=O)Cn1c2cc(F)ccc2oc1=O
Show InChI InChI=1S/C16H12FNO4/c1-21-12-4-2-3-10(7-12)14(19)9-18-13-8-11(17)5-6-15(13)22-16(18)20/h2-8H,9H2,1H3
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n/an/an/a 3.40E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515922
PNG
(CHEMBL4542090)
Show SMILES COc1ccc2oc(=O)n(CC(=O)c3ccc(OC)c(OC)c3)c2c1
Show InChI InChI=1S/C18H17NO6/c1-22-12-5-7-15-13(9-12)19(18(21)25-15)10-14(20)11-4-6-16(23-2)17(8-11)24-3/h4-9H,10H2,1-3H3
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n/an/an/a 3.90E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM50009526
PNG
(CHEMBL3234440)
Show SMILES C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](C1CCCC1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)NC(CO)CO
Show InChI InChI=1S/C30H49N5O6/c1-21(31-26(38)18-22-12-6-5-7-13-22)28(39)34-27(23-14-8-9-15-23)30(41)33-25(16-10-11-17-35(2,3)4)29(40)32-24(19-36)20-37/h5-7,12-13,21,23-25,27,36-37H,8-11,14-20H2,1-4H3,(H3-,31,32,33,34,38,39,40,41)/p+1/t21-,25-,27-/m0/s1
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n/an/an/a 4.10E+3n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay


J Med Chem 57: 2874-83 (2014)


Article DOI: 10.1021/jm401487x
BindingDB Entry DOI: 10.7270/Q2571DJ3
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50282168
PNG
(CHEMBL4175216)
Show SMILES COC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)c1ccccc1)[C@@H](C)O
Show InChI InChI=1S/C58H88N16O14/c1-34(2)26-42(70-49(79)35(3)66-54(84)43(27-37-18-11-9-12-19-37)67-46(77)30-63-51(81)40(23-17-24-62-58(59)60)68-50(80)38-20-13-10-14-21-38)55(85)69-41(22-15-16-25-74(5,6)7)53(83)72-45(32-75)56(86)73-48(36(4)76)57(87)71-44(28-39-29-61-33-65-39)52(82)64-31-47(78)88-8/h9-14,18-21,29,33-36,40-45,48,75-76H,15-17,22-28,30-32H2,1-8H3,(H14-,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,77,79,80,81,82,83,84,85,86,87)/p+1/t35-,36+,40-,41-,42-,43-,44-,45-,48-/m0/s1
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n/an/an/a 5.00E+3n/an/an/an/an/a



University of Connecticut

Curated by ChEMBL


Assay Description
Binding affinity to Cbx7 (unknown origin) by ITC method


Eur J Med Chem 136: 14-35 (2017)


Article DOI: 10.1016/j.ejmech.2017.04.047
BindingDB Entry DOI: 10.7270/Q2F76G3G
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515906
PNG
(CHEMBL4538036)
Show SMILES CN1C(=O)C(O)(CC(=O)c2ccc3ccccc3c2)c2ccccc12
Show InChI InChI=1S/C21H17NO3/c1-22-18-9-5-4-8-17(18)21(25,20(22)24)13-19(23)16-11-10-14-6-2-3-7-15(14)12-16/h2-12,25H,13H2,1H3
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n/an/an/a 5.10E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50155932
PNG
(CHEMBL3780489)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C74H86BrN11O17S/c1-41(2)64(85-70(98)58(35-42-13-7-6-8-14-42)82-66(94)44-19-21-45(75)22-20-44)72(100)83-57(36-43-17-24-47(88)25-18-43)69(97)80-55(16-10-12-34-86(3,4)5)67(95)84-59(40-87)71(99)81-56(31-32-62(91)92)68(96)79-54(65(76)93)15-9-11-33-77-74(104)78-46-23-28-50(53(37-46)73(101)102)63-51-29-26-48(89)38-60(51)103-61-39-49(90)27-30-52(61)63/h6-8,13-14,17-30,37-39,41,54-59,64,87H,9-12,15-16,31-36,40H2,1-5H3,(H14-,76,77,78,79,80,81,82,83,84,85,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,104)/p+1/t54-,55-,56-,57-,58-,59-,64-/m0/s1
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n/an/an/a 5.30E+3n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged human CBX7 (8 to 62) expressed in Escherichia coli BL21 using FITC-peptide-3 as competitive binding probe ...


ACS Med Chem Lett 7: 139-44 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00378
BindingDB Entry DOI: 10.7270/Q2222WNZ
More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM50009475
PNG
(CHEMBL3234157)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@H](CO)C(N)=O
Show InChI InChI=1S/C32H53N7O7/c1-20(2)17-25(32(46)36-24(15-11-12-16-39(5,6)7)30(44)38-27(19-40)28(33)42)37-29(43)21(3)34-31(45)26(35-22(4)41)18-23-13-9-8-10-14-23/h8-10,13-14,20-21,24-27,40H,11-12,15-19H2,1-7H3,(H6-,33,34,35,36,37,38,41,42,43,44,45,46)/p+1/t21-,24-,25-,26-,27+/m0/s1
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n/an/an/a 5.40E+3n/an/an/an/an/a



University of Victoria

Curated by ChEMBL


Assay Description
Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay


J Med Chem 57: 2874-83 (2014)


Article DOI: 10.1021/jm401487x
BindingDB Entry DOI: 10.7270/Q2571DJ3
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515902
PNG
(CHEMBL4451877)
Show SMILES O=C(Cn1c2ccccc2oc1=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C18H23N3O4/c22-17(13-21-15-3-1-2-4-16(15)25-18(21)23)20-7-5-14(6-8-20)19-9-11-24-12-10-19/h1-4,14H,5-13H2
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n/an/an/a 5.60E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515894
PNG
(CHEMBL4569763)
Show SMILES COc1ccc2oc(=O)n(CC(=O)c3ccc(cc3)N(C)C)c2c1
Show InChI InChI=1S/C18H18N2O4/c1-19(2)13-6-4-12(5-7-13)16(21)11-20-15-10-14(23-3)8-9-17(15)24-18(20)22/h4-10H,11H2,1-3H3
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n/an/an/a 6.10E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515917
PNG
(CHEMBL4593169)
Show SMILES Nc1ccc2n(CC(=O)c3c[nH]c4ccccc34)c(=O)sc2c1
Show InChI InChI=1S/C17H13N3O2S/c18-10-5-6-14-16(7-10)23-17(22)20(14)9-15(21)12-8-19-13-4-2-1-3-11(12)13/h1-8,19H,9,18H2
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n/an/an/a 6.50E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50194463
PNG
(CHEMBL3974828)
Show SMILES CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)c1ccccc1)C(=O)N[C@@H](CO)C(=O)OC
Show InChI InChI=1S/C41H61N7O9/c1-7-48(8-2)22-16-15-21-31(38(53)47-34(26-49)41(56)57-6)45-40(55)32(23-27(3)4)46-36(51)28(5)43-39(54)33(24-29-17-11-9-12-18-29)44-35(50)25-42-37(52)30-19-13-10-14-20-30/h9-14,17-20,27-28,31-34,49H,7-8,15-16,21-26H2,1-6H3,(H,42,52)(H,43,54)(H,44,50)(H,45,55)(H,46,51)(H,47,53)/t28-,31-,32-,33-,34-/m0/s1
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n/an/an/a 6.70E+3n/an/an/an/an/a



University of Connecticut

Curated by ChEMBL


Assay Description
Binding affinity to Cbx7 (unknown origin) by ITC method


Eur J Med Chem 136: 14-35 (2017)


Article DOI: 10.1016/j.ejmech.2017.04.047
BindingDB Entry DOI: 10.7270/Q2F76G3G
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515919
PNG
(CHEMBL4465270)
Show SMILES CCCN1C(=O)C(O)(CC(=O)c2ccc3CCCCc3c2)c2ccccc12
Show InChI InChI=1S/C23H25NO3/c1-2-13-24-20-10-6-5-9-19(20)23(27,22(24)26)15-21(25)18-12-11-16-7-3-4-8-17(16)14-18/h5-6,9-12,14,27H,2-4,7-8,13,15H2,1H3
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n/an/an/a 7.20E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515883
PNG
(CHEMBL4435384)
Show SMILES COc1ccc2oc(=O)n(CC(=O)N3CCC(CC3)N3CCCC3)c2c1
Show InChI InChI=1S/C19H25N3O4/c1-25-15-4-5-17-16(12-15)22(19(24)26-17)13-18(23)21-10-6-14(7-11-21)20-8-2-3-9-20/h4-5,12,14H,2-3,6-11,13H2,1H3
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n/an/an/a 8.20E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515882
PNG
(CHEMBL4582102)
Show SMILES [O-][N+](=O)c1ccc2n(CC(=O)c3c[nH]c4ccccc34)c(=O)sc2c1
Show InChI InChI=1S/C17H11N3O4S/c21-15(12-8-18-13-4-2-1-3-11(12)13)9-19-14-6-5-10(20(23)24)7-16(14)25-17(19)22/h1-8,18H,9H2
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n/an/an/a 8.80E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515903
PNG
(CHEMBL4563708)
Show SMILES CCCCN1C(=O)C(O)(CC(=O)c2cccc(OC)c2)c2ccccc12
Show InChI InChI=1S/C21H23NO4/c1-3-4-12-22-18-11-6-5-10-17(18)21(25,20(22)24)14-19(23)15-8-7-9-16(13-15)26-2/h5-11,13,25H,3-4,12,14H2,1-2H3
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n/an/an/a 8.80E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515911
PNG
(CHEMBL4460103)
Show SMILES O=C(Cn1c2ccccc2oc1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H12N2O3/c20-15(12-9-18-13-6-2-1-5-11(12)13)10-19-14-7-3-4-8-16(14)22-17(19)21/h1-9,18H,10H2
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n/an/an/a 9.30E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515914
PNG
(CHEMBL4590713)
Show SMILES Brc1ccc2oc(=O)n(CC(=O)c3ccc4ccccc4c3)c2c1
Show InChI InChI=1S/C19H12BrNO3/c20-15-7-8-18-16(10-15)21(19(23)24-18)11-17(22)14-6-5-12-3-1-2-4-13(12)9-14/h1-10H,11H2
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n/an/an/a 9.50E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515913
PNG
(CHEMBL4448020)
Show SMILES Fc1ccc2oc(=O)n(CC(=O)c3c[nH]c4ccccc34)c2c1
Show InChI InChI=1S/C17H11FN2O3/c18-10-5-6-16-14(7-10)20(17(22)23-16)9-15(21)12-8-19-13-4-2-1-3-11(12)13/h1-8,19H,9H2
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n/an/an/a 9.80E+3n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50194263
PNG
(CHEMBL3970021)
Show SMILES COC(=O)[C@H](CO)NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)c1ccccc1
Show InChI InChI=1S/C40H59N7O9/c1-26(2)22-31(39(54)44-30(20-14-15-21-47(4,5)6)37(52)46-33(25-48)40(55)56-7)45-35(50)27(3)42-38(53)32(23-28-16-10-8-11-17-28)43-34(49)24-41-36(51)29-18-12-9-13-19-29/h8-13,16-19,26-27,30-33,48H,14-15,20-25H2,1-7H3,(H5-,41,42,43,44,45,46,49,50,51,52,53,54)/p+1/t27-,30-,31-,32-,33-/m0/s1
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n/an/an/a 1.03E+4n/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Binding affinity to human C-terminal His-tagged CBX7 chromodomain (8 to 62 residues) expressed in Escherichia coli Rosetta BL21(DE3)pLysS by ITC meth...


J Med Chem 59: 8913-8923 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00801
BindingDB Entry DOI: 10.7270/Q2H1340D
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515930
PNG
(CHEMBL4463055)
Show SMILES CCc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2ccc(Cl)cc12
Show InChI InChI=1S/C18H16ClNO3/c1-2-11-3-5-12(6-4-11)16(21)10-18(23)14-9-13(19)7-8-15(14)20-17(18)22/h3-9,23H,2,10H2,1H3,(H,20,22)
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n/an/an/a 1.21E+4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515896
PNG
(CHEMBL4450033)
Show SMILES O=C(Cn1c2ccccc2oc1=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H25N3O3/c23-18(14-22-16-6-2-3-7-17(16)25-19(22)24)21-12-8-15(9-13-21)20-10-4-1-5-11-20/h2-3,6-7,15H,1,4-5,8-14H2
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n/an/an/a 1.35E+4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515899
PNG
(CHEMBL4464033)
Show SMILES O=C(Cn1c2ccccc2oc1=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H13NO3/c21-17(15-10-9-13-5-1-2-6-14(13)11-15)12-20-16-7-3-4-8-18(16)23-19(20)22/h1-11H,12H2
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n/an/an/a 1.42E+4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515901
PNG
(CHEMBL1524534)
Show SMILES COc1cccc(NC(=O)Cn2c3ccccc3oc2=O)c1
Show InChI InChI=1S/C16H14N2O4/c1-21-12-6-4-5-11(9-12)17-15(19)10-18-13-7-2-3-8-14(13)22-16(18)20/h2-9H,10H2,1H3,(H,17,19)
PDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.48E+4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515935
PNG
(CHEMBL4465769)
Show SMILES CCCN1C(=O)C(O)(CC(=O)c2cc(Br)c(Br)o2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H14Br2ClNO4/c1-2-5-21-12-4-3-9(20)6-10(12)17(24,16(21)23)8-13(22)14-7-11(18)15(19)25-14/h3-4,6-7,24H,2,5,8H2,1H3
PDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.60E+4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515936
PNG
(CHEMBL4551565)
Show SMILES O=C(Cn1c2ccccc2oc1=O)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C18H23N3O3/c22-17(13-21-15-5-1-2-6-16(15)24-18(21)23)20-11-7-14(8-12-20)19-9-3-4-10-19/h1-2,5-6,14H,3-4,7-13H2
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.62E+4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515908
PNG
(CHEMBL4435053)
Show SMILES COc1cccc(c1)C(=O)Cn1c2cc(OC)ccc2oc1=O
Show InChI InChI=1S/C17H15NO5/c1-21-12-5-3-4-11(8-12)15(19)10-18-14-9-13(22-2)6-7-16(14)23-17(18)20/h3-9H,10H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.72E+4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
Chromobox protein homolog 7


(Homo sapiens (Human))
BDBM50515909
PNG
(CHEMBL4517688)
Show SMILES COc1cccc(c1)C(=O)Cn1c2cc(ccc2oc1=O)C#N
Show InChI InChI=1S/C17H12N2O4/c1-22-13-4-2-3-12(8-13)15(20)10-19-14-7-11(9-18)5-6-16(14)23-17(19)21/h2-8H,10H2,1H3
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.96E+4n/an/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human N-terminal GST-tagged CBX7 (1 to 62 residues) expressed in Escherichia coli BL2 by SPR analysis


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111656
More data for this
Ligand-Target Pair
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