Compile Data Set for Download or QSAR
maximum 50k data
Found 30 of ic50 data for polymerid = 7403
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165913(US9067924, 7)
Affinity DataIC50:  2nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165910(US9067924, 4)
Affinity DataIC50:  4nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165909(US9067924, 3)
Affinity DataIC50:  5nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50570460(CHEMBL4854629)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of BACE2 in mouse MIN6 cells expressing wild type TMEM27 assessed as reduction in TMEM27 secretion by MSD electrochemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165912(US9067924, 6)
Affinity DataIC50:  9nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165914(US9067924, 8)
Affinity DataIC50:  16nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486437((2R,5R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluor...)
Affinity DataIC50:  17nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165911(US9067924, 5)
Affinity DataIC50:  21nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486443((2R,5R)-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  33nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165908(US9067924, 2)
Affinity DataIC50:  79nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486438(6-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  95nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165907(US9067924, 1)
Affinity DataIC50:  167nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165916(US9067924, 10)
Affinity DataIC50:  181nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486439(5-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  273nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataIC50:  309nMAssay Description:Inhibition of BACE2 in mouse MIN6 cells expressing TMEM27 assessed as reduction in TMEM27 secretion incubated for 24 hrs by MSD electrochemiluminesce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486442((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  375nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486435((1R,5S,6R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50:  421nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486434((1R,5S,6R)-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-flu...)
Affinity DataIC50:  564nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486453(6-((Z)-2-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  853nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM165915(US9067924, 9)
Affinity DataIC50:  858nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486445((4R,5R)-4-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  1.51E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486441((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,3,3-...)
Affinity DataIC50:  1.59E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486436(6-((Z)-2-(3-((1R,5S,6R)-3-amino-5-(difluoromethyl)...)
Affinity DataIC50:  1.62E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50:  2.73E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486444(6-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  3.87E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486451((R,Z)-5,5-difluoro-4-(2-fluoro-5-(2-fluoro-2-(5-(p...)
Affinity DataIC50:  5.84E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486448(5-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  6.36E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486452((R,Z)-6-(2-(6-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50:  1.14E+4nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486446((4R,5R)-4-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  1.60E+4nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM486449((4R,5R)-4-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2...)
Affinity DataIC50:  1.71E+4nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent