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Compile Data Set for Download or QSAR

Found 305 hits of affinity data for UniProtKB/TrEMBL: O14492   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SH2B adapter protein 2


(Human)
BDBM484440
PNG
(US10934285, Example 24)
Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C28H33ClN8O3S/c29-22-16(33-24(38)21-25(39)35-19-8-1-2-12-37(19)27(21)40)5-3-6-17(22)41-26-23(31)34-20(15-32-26)36-13-10-28(11-14-36)9-4-7-18(28)30/h3,5-6,15,18,39H,1-2,4,7-14,30H2,(H2,31,34)(H,33,38)/t18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484457
PNG
(US10934285, Example 43)
Show SMILES N[C@@H]1CCCC11CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C27H32ClN9O3S/c28-20-15(31-22(38)19-23(39)32-18-8-1-2-12-37(18)25(19)40)5-3-6-16(20)41-24-21(30)33-26(35-34-24)36-13-10-27(11-14-36)9-4-7-17(27)29/h3,5-6,17,39H,1-2,4,7-14,29H2,(H,31,38)(H2,30,33,35)/t17-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484469
PNG
(US10934285, Example 55)
Show SMILES CCC1N(C)C(=O)C(C(=O)Nc2cccc(Sc3ncc(nc3N)N3CCC(C)(N)CC3)c2Cl)=C1O
Show InChI InChI=1S/C24H30ClN7O3S/c1-4-14-19(33)17(23(35)31(14)3)21(34)29-13-6-5-7-15(18(13)25)36-22-20(26)30-16(12-28-22)32-10-8-24(2,27)9-11-32/h5-7,12,14,33H,4,8-11,27H2,1-3H3,(H2,26,30)(H,29,34)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.80n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484472
PNG
(US10934285, Example 59)
Show SMILES CN1C(=O)C(C(=O)Nc2cccc(Sc3ncc(nc3N)N3CCC(C)(N)CC3)c2Cl)=C(O)C1(C)C
Show InChI InChI=1S/C24H30ClN7O3S/c1-23(2)18(33)16(22(35)31(23)4)20(34)29-13-6-5-7-14(17(13)25)36-21-19(26)30-15(12-28-21)32-10-8-24(3,27)9-11-32/h5-7,12,33H,8-11,27H2,1-4H3,(H2,26,30)(H,29,34)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484461
PNG
(US10934285, Example 47)
Show SMILES CC1(N)CCN(CC1)c1nc2ccc(Sc3cccc(NC(=O)C4=C(O)CN(C4=O)c4ccccc4)c3Cl)nc2[nH]1
Show InChI InChI=1S/C29H28ClN7O3S/c1-29(31)12-14-36(15-13-29)28-33-19-10-11-22(34-25(19)35-28)41-21-9-5-8-18(24(21)30)32-26(39)23-20(38)16-37(27(23)40)17-6-3-2-4-7-17/h2-11,38H,12-16,31H2,1H3,(H,32,39)(H,33,34,35)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484421
PNG
(US10934285, Example 5)
Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4cnccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H26ClN9O3S/c1-25(13-27)5-8-34(9-6-25)16-12-30-23(20(28)32-16)39-15-4-2-3-14(19(15)26)31-21(36)18-22(37)33-17-11-29-7-10-35(17)24(18)38/h2-4,7,10-12,37H,5-6,8-9,13,27H2,1H3,(H2,28,32)(H,31,36)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484466
PNG
(US10934285, Example 52)
Show SMILES CC1(N)CCN(CC1)c1nnc(Sc2cccc(NC(=O)C3=C(O)CN(C3=O)c3ccccc3)c2Cl)c(N)n1
Show InChI InChI=1S/C26H27ClN8O3S/c1-26(29)10-12-34(13-11-26)25-31-21(28)23(32-33-25)39-18-9-5-8-16(20(18)27)30-22(37)19-17(36)14-35(24(19)38)15-6-3-2-4-7-15/h2-9,36H,10-14,29H2,1H3,(H,30,37)(H2,28,31,33)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484467
PNG
(US10934285, Example 53)
Show SMILES CC1(N)CCN(CC1)c1cnc(Sc2cccc(NC(=O)C3=C(O)CN(C3=O)c3ccccc3)c2Cl)c(N)n1
Show InChI InChI=1S/C27H28ClN7O3S/c1-27(30)10-12-34(13-11-27)20-14-31-25(23(29)33-20)39-19-9-5-8-17(22(19)28)32-24(37)21-18(36)15-35(26(21)38)16-6-3-2-4-7-16/h2-9,14,36H,10-13,15,30H2,1H3,(H2,29,33)(H,32,37)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484429
PNG
(US10934285, Example 13)
Show SMILES Nc1nc(cnc1Sc1cccc(NC(=O)c2c(O)nc3ccccn3c2=O)c1Cl)N1CCC(N)(CF)CC1
Show InChI InChI=1S/C25H24ClFN8O3S/c26-19-14(31-21(36)18-22(37)33-16-6-1-2-9-35(16)24(18)38)4-3-5-15(19)39-23-20(28)32-17(12-30-23)34-10-7-25(29,13-27)8-11-34/h1-6,9,12,37H,7-8,10-11,13,29H2,(H2,28,32)(H,31,36)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 4.60n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484422
PNG
(US10934285, Example 6)
Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4[nH]ccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C24H26ClN9O3S/c1-24(12-26)5-8-33(9-6-24)15-11-29-21(18(27)31-15)38-14-4-2-3-13(17(14)25)30-19(35)16-20(36)32-23-28-7-10-34(23)22(16)37/h2-4,7,10-11,36H,5-6,8-9,12,26H2,1H3,(H2,27,31)(H,28,32)(H,30,35)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484439
PNG
(US10934285, Example 23)
Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C28H29ClN8O3S/c29-22-16(33-24(38)21-25(39)35-19-8-1-2-12-37(19)27(21)40)5-3-6-17(22)41-26-23(31)34-20(15-32-26)36-13-10-28(11-14-36)9-4-7-18(28)30/h1-3,5-6,8,12,15,18,39H,4,7,9-11,13-14,30H2,(H2,31,34)(H,33,38)/t18-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484430
PNG
(US10934285, Example 14)
Show SMILES Nc1nc(cnc1Sc1cccc(NC(=O)c2c(O)nc3CCCCn3c2=O)c1Cl)N1CCC(N)(CF)CC1
Show InChI InChI=1S/C25H28ClFN8O3S/c26-19-14(31-21(36)18-22(37)33-16-6-1-2-9-35(16)24(18)38)4-3-5-15(19)39-23-20(28)32-17(12-30-23)34-10-7-25(29,13-27)8-11-34/h3-5,12,37H,1-2,6-11,13,29H2,(H2,28,32)(H,31,36)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484426
PNG
(US10934285, Example 10)
Show SMILES NCC1(O)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H25ClN8O4S/c26-19-14(30-21(35)18-22(36)32-16-6-1-2-9-34(16)24(18)37)4-3-5-15(19)39-23-20(28)31-17(12-29-23)33-10-7-25(38,13-27)8-11-33/h1-6,9,12,36,38H,7-8,10-11,13,27H2,(H2,28,31)(H,30,35)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484423
PNG
(US10934285, Example 7)
Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C26H31ClN8O3S/c1-26(14-28)8-11-34(12-9-26)18-13-30-24(21(29)32-18)39-16-6-4-5-15(20(16)27)31-22(36)19-23(37)33-17-7-2-3-10-35(17)25(19)38/h4-6,13,37H,2-3,7-12,14,28H2,1H3,(H2,29,32)(H,31,36)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484419
PNG
(US10934285, Example 3)
Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4sccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C24H25ClN8O3S2/c1-24(12-26)5-7-32(8-6-24)15-11-28-21(18(27)30-15)38-14-4-2-3-13(17(14)25)29-19(34)16-20(35)31-23-33(22(16)36)9-10-37-23/h2-4,9-11,35H,5-8,12,26H2,1H3,(H2,27,30)(H,29,34)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484451
PNG
(US10934285, Example 37)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)C3=C(O)NC4CCCCN4C3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H32ClN9O3S/c1-25(13-27)8-11-34(12-9-25)24-31-19(28)22(32-33-24)39-15-6-4-5-14(18(15)26)29-20(36)17-21(37)30-16-7-2-3-10-35(16)23(17)38/h4-6,16,30,37H,2-3,7-13,27H2,1H3,(H,29,36)(H2,28,31,33)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484470
PNG
(US10934285, Example 56)
Show SMILES CNC1(C)CCN(CC1)c1cnc(Sc2cccc(NC(=O)C3=C(O)CN(C3=O)c3ccccc3)c2Cl)c(N)n1
Show InChI InChI=1S/C28H30ClN7O3S/c1-28(31-2)11-13-35(14-12-28)21-15-32-26(24(30)34-21)40-20-10-6-9-18(23(20)29)33-25(38)22-19(37)16-36(27(22)39)17-7-4-3-5-8-17/h3-10,15,31,37H,11-14,16H2,1-2H3,(H2,30,34)(H,33,38)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 6.60n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484459
PNG
(US10934285, Example 45)
Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)cn1
Show InChI InChI=1S/C26H30ClN7O3S/c1-26(15-28)8-11-33(12-9-26)19-13-30-20(14-29-19)38-17-6-4-5-16(22(17)27)31-23(35)21-24(36)32-18-7-2-3-10-34(18)25(21)37/h4-6,13-14,36H,2-3,7-12,15,28H2,1H3,(H,31,35)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484418
PNG
(US10934285, Example 2)
Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C26H27ClN8O3S/c1-26(14-28)8-11-34(12-9-26)18-13-30-24(21(29)32-18)39-16-6-4-5-15(20(16)27)31-22(36)19-23(37)33-17-7-2-3-10-35(17)25(19)38/h2-7,10,13,37H,8-9,11-12,14,28H2,1H3,(H2,29,32)(H,31,36)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484425
PNG
(US10934285, Example 9)
Show SMILES CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CNCCn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H30ClN9O3S/c1-25(13-27)5-8-34(9-6-25)16-12-30-23(20(28)32-16)39-15-4-2-3-14(19(15)26)31-21(36)18-22(37)33-17-11-29-7-10-35(17)24(18)38/h2-4,12,29,37H,5-11,13,27H2,1H3,(H2,28,32)(H,31,36)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484468
PNG
(US10934285, Example 54)
Show SMILES CN1C(Cc2ccccc2)C(O)=C(C(=O)Nc2cccc(Sc3ncc(nc3N)N3CCC(C)(N)CC3)c2Cl)C1=O
Show InChI InChI=1S/C29H32ClN7O3S/c1-29(32)11-13-37(14-12-29)21-16-33-27(25(31)35-21)41-20-10-6-9-18(23(20)30)34-26(39)22-24(38)19(36(2)28(22)40)15-17-7-4-3-5-8-17/h3-10,16,19,38H,11-15,32H2,1-2H3,(H2,31,35)(H,34,39)
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 7.30n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484432
PNG
(US10934285, Example 16)
Show SMILES NCC1(F)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H28ClFN8O3S/c26-19-14(31-21(36)18-22(37)33-16-6-1-2-9-35(16)24(18)38)4-3-5-15(19)39-23-20(29)32-17(12-30-23)34-10-7-25(27,13-28)8-11-34/h3-5,12,37H,1-2,6-11,13,28H2,(H2,29,32)(H,31,36)
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n/an/a 8n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484446
PNG
(US10934285, Example 32)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4sccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C23H24ClN9O3S2/c1-23(11-25)5-7-32(8-6-23)21-28-16(26)19(30-31-21)38-13-4-2-3-12(15(13)24)27-17(34)14-18(35)29-22-33(20(14)36)9-10-37-22/h2-4,9-10,35H,5-8,11,25H2,1H3,(H,27,34)(H2,26,28,31)
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n/an/a 8n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484447
PNG
(US10934285, Example 33)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H26ClN9O3S/c1-25(13-27)8-11-34(12-9-25)24-31-19(28)22(32-33-24)39-15-6-4-5-14(18(15)26)29-20(36)17-21(37)30-16-7-2-3-10-35(16)23(17)38/h2-7,10,37H,8-9,11-13,27H2,1H3,(H,29,36)(H2,28,31,33)
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n/an/a 10n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484438
PNG
(US10934285, Example 22)
Show SMILES N[C@@H]1C(F)(F)CCC11CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C28H27ClF2N8O3S/c29-20-15(35-22(40)19-23(41)37-17-6-1-2-11-39(17)25(19)42)4-3-5-16(20)43-24-21(32)36-18(14-34-24)38-12-9-27(10-13-38)7-8-28(30,31)26(27)33/h1-6,11,14,26,41H,7-10,12-13,33H2,(H2,32,36)(H,35,40)/t26-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484431
PNG
(US10934285, Example 15)
Show SMILES NCC1(F)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H24ClFN8O3S/c26-19-14(31-21(36)18-22(37)33-16-6-1-2-9-35(16)24(18)38)4-3-5-15(19)39-23-20(29)32-17(12-30-23)34-10-7-25(27,13-28)8-11-34/h1-6,9,12,37H,7-8,10-11,13,28H2,(H2,29,32)(H,31,36)
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n/an/a 10n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484455
PNG
(US10934285, Example 41)
Show SMILES CC1(N)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C24H24ClN9O3S/c1-24(27)8-11-33(12-9-24)23-30-18(26)21(31-32-23)38-14-6-4-5-13(17(14)25)28-19(35)16-20(36)29-15-7-2-3-10-34(15)22(16)37/h2-7,10,36H,8-9,11-12,27H2,1H3,(H,28,35)(H2,26,30,32)
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n/an/a 11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484471
PNG
(US10934285, Example 57)
Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1cnc(Sc2cccc(NC(=O)C3=C(O)CN(C3=O)c3ccccc3)c2Cl)c(N)n1
Show InChI InChI=1S/C27H28ClN7O3S/c1-15-12-34(13-16(2)31-15)21-11-30-26(24(29)33-21)39-20-10-6-9-18(23(20)28)32-25(37)22-19(36)14-35(27(22)38)17-7-4-3-5-8-17/h3-11,15-16,31,36H,12-14H2,1-2H3,(H2,29,33)(H,32,37)/t15-,16+
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n/an/a 11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484473
PNG
(US10934285, Example 60)
Show SMILES OC1=C(C(=O)Nc2cccc(Sc3ccc4nc([nH]c4n3)N3CCCCC3)c2Cl)C(=O)N[C@H]1Cc1ccccc1
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n/an/a 11n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484427
PNG
(US10934285, Example 11)
Show SMILES NCC1(O)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H29ClN8O4S/c26-19-14(30-21(35)18-22(36)32-16-6-1-2-9-34(16)24(18)37)4-3-5-15(19)39-23-20(28)31-17(12-29-23)33-10-7-25(38,13-27)8-11-33/h3-5,12,36,38H,1-2,6-11,13,27H2,(H2,28,31)(H,30,35)
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n/an/a 12n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484465
PNG
(US10934285, Example 51)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)C3=C(O)CN(C3=O)c3ccccc3)c2Cl)c(N)n1
Show InChI InChI=1S/C27H29ClN8O3S/c1-27(15-29)10-12-35(13-11-27)26-32-22(30)24(33-34-26)40-19-9-5-8-17(21(19)28)31-23(38)20-18(37)14-36(25(20)39)16-6-3-2-4-7-16/h2-9,37H,10-15,29H2,1H3,(H,31,38)(H2,30,32,34)
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n/an/a 12n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484443
PNG
(US10934285, Example 29)
Show SMILES CC[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3cccc(NC(=O)c4c(O)nc5CCCCn5c4=O)c3Cl)c(N)n2)[C@@H]1N
Show InChI InChI=1S/C29H35ClN8O4S/c1-2-17-23(31)29(15-42-17)9-12-37(13-10-29)20-14-33-27(24(32)35-20)43-18-7-5-6-16(22(18)30)34-25(39)21-26(40)36-19-8-3-4-11-38(19)28(21)41/h5-7,14,17,23,40H,2-4,8-13,15,31H2,1H3,(H2,32,35)(H,34,39)/t17-,23+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484450
PNG
(US10934285, Example 36)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C25H30ClN9O3S/c1-25(13-27)8-11-34(12-9-25)24-31-19(28)22(32-33-24)39-15-6-4-5-14(18(15)26)29-20(36)17-21(37)30-16-7-2-3-10-35(16)23(17)38/h4-6,37H,2-3,7-13,27H2,1H3,(H,29,36)(H2,28,31,33)
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n/an/a 12n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484453
PNG
(US10934285, Example 39)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4c5ccccc5ccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C29H28ClN9O3S/c1-29(15-31)10-13-38(14-11-29)28-34-22(32)26(36-37-28)43-19-8-4-7-18(21(19)30)33-24(40)20-25(41)35-23-17-6-3-2-5-16(17)9-12-39(23)27(20)42/h2-9,12,41H,10-11,13-15,31H2,1H3,(H,33,40)(H2,32,34,37)
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n/an/a 13n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484433
PNG
(US10934285, Example 17)
Show SMILES NCC1CCN(C1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C24H23ClN8O3S/c25-19-14(29-21(34)18-22(35)31-16-6-1-2-8-33(16)24(18)36)4-3-5-15(19)37-23-20(27)30-17(11-28-23)32-9-7-13(10-26)12-32/h1-6,8,11,13,35H,7,9-10,12,26H2,(H2,27,30)(H,29,34)
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n/an/a 13n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484458
PNG
(US10934285, Example 44)
Show SMILES CC1(N)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)cn1
Show InChI InChI=1S/C25H28ClN7O3S/c1-25(27)8-11-32(12-9-25)18-13-29-19(14-28-18)37-16-6-4-5-15(21(16)26)30-22(34)20-23(35)31-17-7-2-3-10-33(17)24(20)36/h4-6,13-14,35H,2-3,7-12,27H2,1H3,(H,30,34)
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n/an/a 14n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484448
PNG
(US10934285, Example 34)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4cnccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C24H25ClN10O3S/c1-24(12-26)5-8-34(9-6-24)23-31-18(27)21(32-33-23)39-14-4-2-3-13(17(14)25)29-19(36)16-20(37)30-15-11-28-7-10-35(15)22(16)38/h2-4,7,10-11,37H,5-6,8-9,12,26H2,1H3,(H,29,36)(H2,27,31,33)
PDB
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n/an/a 14n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484452
PNG
(US10934285, Example 38)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)n4c(ccc5ccccc45)nc3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C29H28ClN9O3S/c1-29(15-31)11-13-38(14-12-29)28-35-23(32)26(36-37-28)43-19-8-4-6-17(22(19)30)33-24(40)21-25(41)34-20-10-9-16-5-2-3-7-18(16)39(20)27(21)42/h2-10,42H,11-15,31H2,1H3,(H,33,40)(H2,32,35,37)
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n/an/a 15n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484456
PNG
(US10934285, Example 42)
Show SMILES N[C@@H]1CCCC11CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C27H28ClN9O3S/c28-20-15(31-22(38)19-23(39)32-18-8-1-2-12-37(18)25(19)40)5-3-6-16(20)41-24-21(30)33-26(35-34-24)36-13-10-27(11-14-36)9-4-7-17(27)29/h1-3,5-6,8,12,17,39H,4,7,9-11,13-14,29H2,(H,31,38)(H2,30,33,35)/t17-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484444
PNG
(US10934285, Example 30)
Show SMILES C[C@@H]1CC2(CCN(CC2)c2cnc(Sc3cccc(NC(=O)c4c(O)nc5CCCCn5c4=O)c3Cl)c(N)n2)[C@H](N)[C@H]1F
Show InChI InChI=1S/C29H34ClFN8O3S/c1-15-13-29(23(32)22(15)31)8-11-38(12-9-29)19-14-34-27(24(33)36-19)43-17-6-4-5-16(21(17)30)35-25(40)20-26(41)37-18-7-2-3-10-39(18)28(20)42/h4-6,14-15,22-23,41H,2-3,7-13,32H2,1H3,(H2,33,36)(H,35,40)/t15-,22+,23-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484474
PNG
(US10934285, Example 61)
Show SMILES CN1C(Cc2ccccc2)C(O)=C(C(=O)Nc2cccc(Sc3ccc4nc([nH]c4n3)N3CCCCC3)c2Cl)C1=O
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n/an/a 22n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484441
PNG
(N-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8...)
Show SMILES C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3cccc(NC(=O)c4c(O)nc5CCCCn5c4=O)c3Cl)c(N)n2)[C@@H]1N
Show InChI InChI=1S/C28H33ClN8O4S/c1-15-22(30)28(14-41-15)8-11-36(12-9-28)19-13-32-26(23(31)34-19)42-17-6-4-5-16(21(17)29)33-24(38)20-25(39)35-18-7-2-3-10-37(18)27(20)40/h4-6,13,15,22,39H,2-3,7-12,14,30H2,1H3,(H2,31,34)(H,33,38)/t15-,22+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484475
PNG
(US10934285, Example 62)
Show SMILES CCC1N(C)C(=O)C(C(=O)Nc2cccc(Sc3ccc4nc([nH]c4n3)N3CCCCC3)c2Cl)=C1O
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n/an/a 25n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484449
PNG
(US10934285, Example 35)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4[nH]ccn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C23H25ClN10O3S/c1-23(11-25)5-8-33(9-6-23)22-29-16(26)19(31-32-22)38-13-4-2-3-12(15(13)24)28-17(35)14-18(36)30-21-27-7-10-34(21)20(14)37/h2-4,7,10,36H,5-6,8-9,11,25H2,1H3,(H,27,30)(H,28,35)(H2,26,29,32)
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UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484463
PNG
(US10934285, Example 49)
Show SMILES Oc1c(C(=O)Nc2cccc(Sc3ccc4nc([nH]c4n3)N3CCCCC3)c2Cl)c(=O)[nH]c2nccnc12
Show InChI InChI=1S/C25H21ClN8O3S/c26-18-13(29-23(36)17-20(35)19-22(32-24(17)37)28-10-9-27-19)5-4-6-15(18)38-16-8-7-14-21(31-16)33-25(30-14)34-11-2-1-3-12-34/h4-10H,1-3,11-12H2,(H,29,36)(H,30,31,33)(H2,28,32,35,37)
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US Patent
n/an/a 36n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484445
PNG
(US10934285, Example 31)
Show SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4ccccc4c3O)c2Cl)c(N)n1
Show InChI InChI=1S/C26H27ClN8O3S/c1-26(13-28)9-11-35(12-10-26)25-32-21(29)24(33-34-25)39-17-8-4-7-16(19(17)27)31-23(38)18-20(36)14-5-2-3-6-15(14)30-22(18)37/h2-8H,9-13,28H2,1H3,(H,31,38)(H2,29,32,34)(H2,30,36,37)
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US Patent
n/an/a 38n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484442
PNG
(US10934285, Example 28)
Show SMILES N[C@@H]1CC(F)(F)CC11CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1
Show InChI InChI=1S/C28H31ClF2N8O3S/c29-21-15(35-23(40)20-24(41)37-18-6-1-2-9-39(18)26(20)42)4-3-5-16(21)43-25-22(33)36-19(13-34-25)38-10-7-27(8-11-38)14-28(30,31)12-17(27)32/h3-5,13,17,41H,1-2,6-12,14,32H2,(H2,33,36)(H,35,40)/t17-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484478
PNG
(US10934285, Example 65)
Show SMILES CN1C(=O)C(C(=O)Nc2cccc(Sc3ccc4nc([nH]c4n3)N3CCCCC3)c2Cl)=C(O)C1(C)C
Show InChI InChI=1S/C25H27ClN6O3S/c1-25(2)20(33)18(23(35)31(25)3)22(34)27-14-8-7-9-16(19(14)26)36-17-11-10-15-21(29-17)30-24(28-15)32-12-5-4-6-13-32/h7-11,33H,4-6,12-13H2,1-3H3,(H,27,34)(H,28,29,30)
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US Patent
n/an/a 42n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484424
PNG
(US10934285, Example 8)
Show SMILES Cn1c2ccccc2c(O)c(C(=O)Nc2cccc(Sc3ncc(nc3N)N3CCC(C)(CN)CC3)c2Cl)c1=O
Show InChI InChI=1S/C28H30ClN7O3S/c1-28(15-30)10-12-36(13-11-28)20-14-32-26(24(31)34-20)40-19-9-5-7-17(22(19)29)33-25(38)21-23(37)16-6-3-4-8-18(16)35(2)27(21)39/h3-9,14,37H,10-13,15,30H2,1-2H3,(H2,31,34)(H,33,38)
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n/an/a 44n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...


US Patent US10934285 (2021)

More data for this
Ligand-Target Pair
SH2B adapter protein 2


(Human)
BDBM484752
PNG
(Synthesis of 1-(4-{6-[(3R)-3-amino-1,3-dihydrospir...)
Show SMILES CC(=O)N1CCN(c2n[nH]c3nc(cnc23)N2CCC3(Cc4ccccc4[C@@H]3N)CC2)c2ccccc12
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US Patent
n/an/a<50n/an/an/an/an/an/a



Relay Therapeutics, Inc.

US Patent


Assay Description
SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...


US Patent US10934302 (2021)

More data for this
Ligand-Target Pair
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