Compile Data Set for Download or QSAR
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Found 24 Enz. Inhib. hit(s) with all data for entry = 50047820
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human recombinant 5-HT2b receptor expressed in CHO cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKd:  3.70E+3nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM237921(US9394285, 2)
Affinity DataKd:  150nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit gamma-1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50:  7nMAssay Description:Activation of recombinant rat AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphorylat...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit gamma-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha2/beta2/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50:  8.20nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 assessed as protection from Thr172 residue dephosphorylation preincubated for 15 mins follow...More data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50:  3.30nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50:  28nMAssay Description:Activation of recombinant human BAP-tagged AMPK alpha1/beta1/gamma1 assessed as protection from Thr172 residue dephosphorylation preincubated for 15 ...More data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha1/beta2/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Affinity DataEC50:  323nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM237952(US9394285, 33)
Affinity DataEC50:  80nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM237921(US9394285, 2)
Affinity DataEC50:  53nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50191352(CHEMBL3936376)
Affinity DataKd:  9.95E+3nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM237952(US9394285, 33)
Affinity DataKd:  90nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM237984(US9394285, 67)
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50:  6.80nMAssay Description:Activation of recombinant human AMPK alpha2/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha2/beta2/gamma3 by using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191352(CHEMBL3936376)
Affinity DataEC50:  3.39E+3nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM60978(6-Chloro-5-(4-methoxyphenyl)-1H-indazole-3-carboxy...)
Affinity DataKd:  1.78E+3nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM237984(US9394285, 67)
Affinity DataEC50:  1.30nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM237920(US9394285, 1)
Affinity DataKd:  9nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  1.52E+3nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
LigandPNGBDBM237920(US9394285, 1)
Affinity DataEC50:  7nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair