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Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with all data for assayid = 9 entry = 50012384   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens (Human))
BDBM50118343
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CC(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C8H10ClN3O2S2/c1-4(2)10-8-11-5-3-6(9)15-7(5)16(13,14)12-8/h3-4H,1-2H3,(H2,10,11,12)
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PubMed
n/an/a 5.54E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens (Human))
BDBM50118359
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Show SMILES CC1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
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n/an/a 6.85E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens (Human))
BDBM86248
PNG
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)
Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
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n/an/a 7.50E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens (Human))
BDBM50118351
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CC1(CCC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C10H12ClN3O2S2/c1-10(3-2-4-10)13-9-12-6-5-7(11)17-8(6)18(15,16)14-9/h5H,2-4H2,1H3,(H2,12,13,14)
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n/an/a 8.59E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens (Human))
BDBM50118348
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CCC(C)(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C10H14ClN3O2S2/c1-4-10(2,3)13-9-12-6-5-7(11)17-8(6)18(15,16)14-9/h5H,4H2,1-3H3,(H2,12,13,14)
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n/an/a 8.99E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens (Human))
BDBM50118355
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES CCCNC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C8H10ClN3O2S2/c1-2-3-10-8-11-5-4-6(9)15-7(5)16(13,14)12-8/h4H,2-3H2,1H3,(H2,10,11,12)
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n/an/a 9.24E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens (Human))
BDBM50118349
PNG
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Show SMILES Clc1cc2N=C(NC3CCC3)NS(=O)(=O)c2s1
Show InChI InChI=1S/C9H10ClN3O2S2/c10-7-4-6-8(16-7)17(14,15)13-9(12-6)11-5-2-1-3-5/h4-5H,1-3H2,(H2,11,12,13)
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n/an/a 9.43E+5n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1


(Homo sapiens (Human))
BDBM50118360
PNG
(CHEMBL336586 | tert-Butyl-(2-chloro-7,7-dioxo-4,7-...)
Show SMILES CC(C)(C)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1
Show InChI InChI=1S/C9H12ClN3O2S2/c1-9(2,3)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,1-3H3,(H2,11,12,13)
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n/an/a 1.35E+6n/an/an/an/an/an/a



Novo Nordisk Research and Development

Curated by ChEMBL


Assay Description
Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...


J Med Chem 45: 4171-87 (2002)


Article DOI: 10.1021/jm0208121
BindingDB Entry DOI: 10.7270/Q2SF2VGM
More data for this
Ligand-Target Pair