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Found 353 of ph data with Target = 'Aurora kinase A'
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25656(N-(4-fluorophenyl)-1,3-thiazol-2-amine | aminothia...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM239966(US9403801, 31)
Affinity DataIC50:  4nMpH: 7.0 T: 2°CAssay Description:Aurora-A (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 μM LRRASLG (Kemptide), 10 mM MgAcetate and [γ-33P-ATP](specific activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25658(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  400nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25659(4-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25660(N-(4-fluorophenyl)-5-iodo-1,3-thiazol-2-amine | am...)
Affinity DataIC50:  500nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25661(5-bromo-N-(4-fluorophenyl)-N-methyl-1,3-thiazol-2-...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25662(5-bromo-N-phenyl-1,3-thiazol-2-amine | aminothiazo...)
Affinity DataIC50:  1.10E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25663(5-bromo-N-(4-chlorophenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  3.00E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25664(5-bromo-N-(4-bromophenyl)-1,3-thiazol-2-amine | am...)
Affinity DataIC50:  2.90E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25665(5-bromo-N-(4-iodophenyl)-1,3-thiazol-2-amine | ami...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25666(5-bromo-N-(4-methylphenyl)-1,3-thiazol-2-amine | a...)
Affinity DataIC50:  2.84E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25667(5-bromo-N-[4-(trifluoromethyl)phenyl]-1,3-thiazol-...)
Affinity DataIC50:  2.40E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25668(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzonitrile | ...)
Affinity DataIC50:  2.10E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25669(4-[(5-bromo-1,3-thiazol-2-yl)amino]phenol | aminot...)
Affinity DataIC50:  510nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25670(5-bromo-N-(4-methoxyphenyl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  1.70E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25671(5-bromo-N-[4-(trifluoromethoxy)phenyl]-1,3-thiazol...)
Affinity DataIC50:  1.72E+4nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25672(5-bromo-N-(4-phenoxyphenyl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  1.40E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25673(5-bromo-N-[4-(pyridin-4-yloxy)phenyl]-1,3-thiazol-...)
Affinity DataIC50:  900nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25674(1-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}ethan...)
Affinity DataIC50:  1.70E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25675(5-bromo-N-(4-nitrophenyl)-1,3-thiazol-2-amine | am...)
Affinity DataIC50:  1.30E+4nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25676(1-N-(5-bromo-1,3-thiazol-2-yl)benzene-1,4-diamine ...)
Affinity DataIC50:  600nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25677(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}benza...)
Affinity DataIC50:  9.20E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25678(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}aceta...)
Affinity DataIC50:  360nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25679(aminothiazole analogue, 23 | ethyl 4-[(5-bromo-1,3...)
Affinity DataIC50:  5.70E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25680(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Affinity DataIC50:  79nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25681(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Affinity DataIC50:  140nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25682(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-hydroxyet...)
Affinity DataIC50:  1.48E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25683(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Affinity DataIC50:  97nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25684(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(1-methoxypr...)
Affinity DataIC50:  330nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25685(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Affinity DataIC50:  980nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataIC50:  910nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27077(N-[3-(1H-1,3-benzodiazol-2-yl)-1H-pyrazol-4-yl]ace...)
Affinity DataIC50:  70nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27078(N-[3-(1H-1,3-benzodiazol-2-yl)-1H-pyrazol-4-yl]ben...)
Affinity DataIC50:  5.90nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27079(N-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  3.5nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27080(4-fluoro-N-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-ben...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  1.40nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27081(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  12nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27082(1-(2-fluorophenyl)-3-{3-[5-(morpholin-4-ylmethyl)-...)
Affinity DataIC50:  2.80nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27083(1-(2,6-difluorophenyl)-3-{3-[5-(morpholin-4-ylmeth...)
Affinity DataIC50:  1.5nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27084(1-cyclohexyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3...)
Affinity DataIC50:  5.70nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27085(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  13nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27086(3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-...)
Affinity DataIC50:  26nMpH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DatapH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM239963(US9403801, 28)
Affinity DataIC50:  22nMpH: 7.0 T: 2°CAssay Description:Aurora-A (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 μM LRRASLG (Kemptide), 10 mM MgAcetate and [γ-33P-ATP](specific activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Novartis

LigandPNGBDBM25657(5-chloro-N-(4-fluorophenyl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  1.10E+3nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26309(CHEMBL459888 | N-[4-(2-{thieno[3,2-d]pyrimidin-4-y...)
Affinity DataIC50:  3.20E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26334(1-{3-[2-(azetidin-1-yl)ethyl]phenyl}-3-[5-(2-{thie...)
Affinity DataIC50:  53nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26311(3-[4-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)ph...)
Affinity DataIC50:  1.20E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26312(3-[3-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)ph...)
Affinity DataIC50: >2.00E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26313(3-[1-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)
Affinity DataIC50:  1.20E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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