Compile Data Set for Download or QSAR
maximum 50k data
Found 1099 of ph data with Target = 'Transient receptor potential cation channel subfamily V member 1'
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.5nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221947(1-(4-chloro-5-(4-(trifluoromethyl)phenyl)-1H-imida...)
Affinity DataIC50: >4.00E+3nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.5nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261645(4-(3-Amino-2-oxo-1,2-dihydroquinoxalin-5-yloxy)-6-...)
Affinity DataIC50:  2.60nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261646((R)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...)
Affinity DataIC50:  0.300nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261316(3-Amino-5-(6-(2-(2-morpholinoethylamino)-6-(triflu...)
Affinity DataIC50:  19nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261318(3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)-2...)
Affinity DataIC50:  5.90nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261317(3-Amino-5-(6-(2-((1-isobutylpiperidin-2-yl)methyla...)
Affinity DataIC50:  1.70nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261320(3-Amino-5-(2-amino-6-(2-amino-4-(trifluoromethyl)p...)
Affinity DataIC50:  62nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261319(3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)-2...)
Affinity DataIC50:  2.70nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086717(JNJ-39439335 | Mavatrep)
Affinity DataIC50:  6.80nMpH: 5.0Assay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5-induced current measured for 150 secs by patc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221946(1-(4,5-bis(4-(trifluoromethyl)phenyl)-1H-imidazol-...)
Affinity DataIC50:  146nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221950(1-(4,5-bis(3,4,5-trifluorophenyl)-1H-imidazol-2-yl...)
Affinity DataIC50:  32nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221951(CHEMBL247008 | methyl 5-(4-(trifluoromethyl)phenyl...)
Affinity DataIC50:  180nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221953(CHEMBL394102 | N-((1-ethylpyrrolidin-2-yl)methyl)-...)
Affinity DataIC50:  3.30E+3nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221954((R)-(5-chloro-6-(3-methyl-4-(4-phenyl-5-(4-(triflu...)
Affinity DataIC50:  29nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221945((4-isopropylpiperazin-1-yl)(5-(4-(trifluoromethyl)...)
Affinity DataIC50:  1.00E+3nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221944(1-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imida...)
Affinity DataIC50: >4.00E+3nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221949(1-(4-(3,5-difluorophenyl)-5-(4-(trifluoromethyl)ph...)
Affinity DataIC50:  85nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221955((R)-2-methyl-1-(4-phenyl-5-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  341nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221958(1-(5-(4-(trifluoromethyl)phenyl)-4-(3,4,5-trifluor...)
Affinity DataIC50:  20nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221952((R)-(5-chloro-6-(3-methyl-4-(5-(4-(trifluoromethyl...)
Affinity DataIC50:  4nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221957(1-(5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)...)
Affinity DataIC50: >4.00E+3nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221960(CHEMBL394101 | N-((1-isobutylpiperidin-2-yl)methyl...)
Affinity DataIC50: >4.00E+3nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221948(CHEMBL247858 | N-(piperidin-2-ylmethyl)-5-(4-(trif...)
Affinity DataIC50: >4.00E+3nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221956((5-chloro-6-(4-(4-phenyl-5-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  160nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221961(1-(4-phenyl-5-(3-(trifluoromethyl)phenyl)-1H-imida...)
Affinity DataIC50:  165nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50221959(1-(4-phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imida...)
Affinity DataIC50:  216nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed blocking of acid-induced calcium influx at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50315615(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...)
Affinity DataIC50:  3.25nMpH: 5.0Assay Description:Inhibition of rat TRPV1 at pH 5 to 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  40nMpH: 5.3Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Cavia porcellus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  63nMpH: 5.3Assay Description:Antagonist activity at guinea pig TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  100nMpH: 5.3Assay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  9nMpH: 5.3Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by whole cell patch clamp a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184729(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)
Affinity DataIC50:  4nMpH: 5.5Assay Description:Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  3nMpH: 5.5Assay Description:Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184730(4-(trifluoromethyl)-N-(4-(3-(trifluoromethyl)pyrid...)
Affinity DataIC50:  33nMpH: 5.5Assay Description:Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50232114((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50:  0.700nMpH: 5.5Assay Description:Blockade of pH 5.5-induced activation of TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20466(A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...)
Affinity DataIC50:  1.40E+4nMpH: 5.5Assay Description:Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of pH 5.5-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50319454(1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl...)
Affinity DataIC50:  7nMpH: 5.5Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced effect at pH 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50319473(1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl...)
Affinity DataIC50:  69nMpH: 5.5Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced effect at pH 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50319472(1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl...)
Affinity DataIC50:  53nMpH: 5.5Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced effect at pH 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50160304(6-tert-Butyl-2-[(S)-4-(3-chloro-pyridin-2-yl)-2-me...)
Affinity DataIC50:  3.61E+3nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212314((R)-6-tert-butyl-2-(2-methyl-4-(3-(trifluoromethyl...)
Affinity DataIC50:  1.78E+3nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50160302(2-[(S)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazi...)
Affinity DataIC50: >2.50E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50160301(2-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-5,6-d...)
Affinity DataIC50: >2.50E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50160307(5-tert-Butyl-2-[(R)-4-(3-chloro-pyridin-2-yl)-2-me...)
Affinity DataIC50:  1.41E+3nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50160311(6-tert-Butyl-2-[(R)-4-(4-chloro-[1,2,5]thiadiazol-...)
Affinity DataIC50: >1.00E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212313((R)-6-tert-butyl-2-(4-(3-chloropyridin-2-yl)-2-met...)
Affinity DataIC50:  104nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212315((R)-6-tert-butyl-2-(2-methyl-4-(3-methylpyridin-2-...)
Affinity DataIC50:  597nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50160308(2-[(R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazi...)
Affinity DataIC50:  1.00E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 1099 total ) | Next | Last >>
Jump to: