Compile Data Set for Download or QSAR
maximum 50k data
Found 204 of ec50 data for polymerid = 1072
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273338((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50:  0.5nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273990((S)-1-(4-Fluorobenzyl)-5-(2-(tetrahydro-2H-pyran-4...)
Affinity DataEC50:  2.30nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273991((S)-1-(4-Fluorobenzyl)-5-(2-(pyrimidin-4-yloxymeth...)
Affinity DataEC50:  5.5nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273929((S)-1-(4-Fluorobenzyl)-5-(2-(2,4-difluorophenoxyme...)
Affinity DataEC50:  12.4nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273339((S)-1-(4-Fluorobenzyl)-5-(2-((1-(2-fluoroethyl)-1H...)
Affinity DataEC50:  12.6nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273337((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50:  16.7nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273989((S)-1-(4-Fluorobenzyl)-5-(2-(3,5-difluorophenoxyme...)
Affinity DataEC50:  16.8nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273928((S)-1-(4-Fluorobenzyl)-5-(2-(3-fluorophenoxymethyl...)
Affinity DataEC50:  17nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50200305((S)-1-(4-iodobenzyl)-5-(2-phenoxymethyl-pyrrolidin...)
Affinity DataEC50:  25.3nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273927((S)-1-(4-Fluorobenzyl)-5-(2-(4-fluorophenoxymethyl...)
Affinity DataEC50:  26.1nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataEC50:  41.8nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273992((S)-1-(2-Propynyl)-5-(2-(2,4-difluorophenoxymethyl...)
Affinity DataEC50:  50.1nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10331((S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolid...)
Affinity DataEC50:  78.6nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273926(1-(4-Fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isati...)
Affinity DataEC50:  200nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM36363(CID6851947 | PAC-1 | US10166229, Example PAC-1)
Affinity DataEC50:  220nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM36363(CID6851947 | PAC-1 | US10166229, Example PAC-1)
Affinity DataEC50:  220nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171427(5-[5-(3-Chloro-thiophen-2-yl)-[1,2,4]oxadiazol-3-y...)
Affinity DataEC50:  240nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50102103(CHEMBL3330161)
Affinity DataEC50:  250nMAssay Description:Induction of procaspase 3 activity (unknown origin) using Ac-DEVD-pNa as substrate after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171417(5-(3-Chloro-thiophen-2-yl)-3-(3-trifluoromethyl-ph...)
Affinity DataEC50:  280nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171432(2-Chloro-5-[5-(3-chloro-thiophen-2-yl)-[1,2,4]oxad...)
Affinity DataEC50:  290nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50340543((S)-1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)me...)
Affinity DataEC50:  350nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171422(5-(3-Chloro-thiophen-2-yl)-3-(3,4-dichloro-phenyl)...)
Affinity DataEC50:  370nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171435(3-(4-Chloro-2-methyl-phenyl)-5-(3-chloro-thiophen-...)
Affinity DataEC50:  380nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50340529((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-((pyridin-3-...)
Affinity DataEC50:  380nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50340533((S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-((pyridin-3-...)
Affinity DataEC50:  390nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171414(5-Chloro-2-[5-(3-chloro-thiophen-2-yl)-[1,2,4]oxad...)
Affinity DataEC50:  390nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171433(2-[5-(3-Chloro-thiophen-2-yl)-[1,2,4]oxadiazol-3-y...)
Affinity DataEC50:  410nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM77501((5E)-2-(4-methoxyphenyl)-5-(3,4,5-trimethoxybenzyl...)
Affinity DataEC50:  420nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSR...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50340542((S)-1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)me...)
Affinity DataEC50:  420nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM36364(CID9543559 | De-ally PAC-1 | US10166229, Example d...)
Affinity DataEC50:  430nMpH: 7.4 T: 2°CAssay Description:Procaspase-3 activation assay; activation of procaspase-3 to caspase-3. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM36364(CID9543559 | De-ally PAC-1 | US10166229, Example d...)
Affinity DataEC50:  430nMAssay Description:Procaspase-3 was recombinantly expressed in E. coli with an N-terminal His-6 tag (SEQ ID NO: 29) and purified. Immunoblotting was performed with an a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171425(5-(3-Chloro-thiophen-2-yl)-3-(4-trifluoromethoxy-p...)
Affinity DataEC50:  430nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171412(5-(3-Chloro-thiophen-2-yl)-3-(4-trifluoromethyl-ph...)
Affinity DataEC50:  440nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50340530((S)-1-(4-methoxybenzyl)-5-(2-((pyridin-3-yloxy)met...)
Affinity DataEC50:  450nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)
Affinity DataEC50:  450nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171411(5-(3-Chloro-furan-2-yl)-3-(4-trifluoromethyl-pheny...)
Affinity DataEC50:  480nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171411(5-(3-Chloro-furan-2-yl)-3-(4-trifluoromethyl-pheny...)
Affinity DataEC50:  520nMAssay Description:Caspase-3 activation activity tested in T47D breast cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171437(5-(3-Chloro-thiophen-2-yl)-3-(4-chloro-3-trifluoro...)
Affinity DataEC50:  560nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171436(5-Chloro-2-[5-(3-chloro-furan-2-yl)-[1,2,4]oxadiaz...)
Affinity DataEC50:  580nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171429(2-[5-(3-Bromo-furan-2-yl)-[1,2,4]oxadiazol-3-yl]-5...)
Affinity DataEC50:  610nMAssay Description:Caspase-3 activation activity tested in T47D breast cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10350(1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine...)
Affinity DataEC50:  650nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273338((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50:  680nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171429(2-[5-(3-Bromo-furan-2-yl)-[1,2,4]oxadiazol-3-yl]-5...)
Affinity DataEC50:  700nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171432(2-Chloro-5-[5-(3-chloro-thiophen-2-yl)-[1,2,4]oxad...)
Affinity DataEC50:  750nMAssay Description:Caspase-3 activation activity tested in T47D breast cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171412(5-(3-Chloro-thiophen-2-yl)-3-(4-trifluoromethyl-ph...)
Affinity DataEC50:  760nMAssay Description:Caspase-3 activation activity tested in HT-29 cancer cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171409(5-(3-Chloro-thiophen-2-yl)-3-phenyl-[1,2,4]oxadiaz...)
Affinity DataEC50:  760nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171430(3-(4-Chloro-phenyl)-5-(3-chloro-thiophen-2-yl)-[1,...)
Affinity DataEC50:  790nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50340541((S)-1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)me...)
Affinity DataEC50:  800nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171424(5-(3-Bromo-furan-2-yl)-3-(4-chloro-phenyl)-[1,2,4]...)
Affinity DataEC50:  830nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50171413(2-[5-(3-Bromo-furan-2-yl)-[1,2,4]oxadiazol-3-yl]-5...)
Affinity DataEC50:  840nMAssay Description:Caspase-3 activation activity tested in DLD1 colon cells done for 24 or 48 h at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 204 total ) | Next | Last >>
Jump to: