Compile Data Set for Download or QSAR
maximum 50k data
Found 112 of ec50 data for polymerid = 2132,50001251
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataEC50:  1.90nMAssay Description:Binding affinity to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50412441(CHEMBL490417 | SB-744185)
Affinity DataEC50:  7.94nMAssay Description:Inhibition of human ERG current by whole cell electrophisiology studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Affinity DataEC50:  25nMAssay Description:Inhibition of human ERG assessed as reduction of tail currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50222113(7-(5-methyl-3-isoxazolyl)-3-(3-{[4-methyl-5-(2-met...)
Affinity DataEC50:  120nMAssay Description:Binding affinity to hERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataEC50:  290nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50596268(CHEMBL5203592)
Affinity DataEC50:  500nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50577484(CHEMBL4863873)
Affinity DataEC50:  780nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50517811(CHEMBL4576867)
Affinity DataEC50:  900nMAssay Description:Activation of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50577483(CHEMBL4869437)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114807(CHEMBL3608385)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50562042(CHEMBL4792742)
Affinity DataEC50:  1.52E+3nMAssay Description:Inhibition of fluorescently labelled tracer binding to human ERG by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50596267(CHEMBL5172698)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50596269(CHEMBL5183842)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114806(CHEMBL3609752)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275887(CHEMBL470582 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataEC50:  3.30E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275888(CHEMBL470798 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataEC50:  3.35E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50596270(CHEMBL5186572)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50577482(CHEMBL4848550)
Affinity DataEC50:  4.40E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50394745(CHEMBL2165821)
Affinity DataEC50:  4.50E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential assessed as reduction in tail current amplitude by conventional patch c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50391759(CHEMBL2146751)
Affinity DataEC50:  4.60E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase component GSC2(Saccharomyces cerevisiae)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50499726(CHEMBL3742181)
Affinity DataEC50:  4.60E+3nMAssay Description:Induction of dissociation of [3H]-dofetilide from Kv11.1 channel (unknown origin) assessed as dissociation rate expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50357687(CHEMBL1956112)
Affinity DataEC50:  4.70E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential assessed as reduction in tail current amplitude by conventional patch c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275886(8-(5-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)pyr...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50182587(5-acetyl-4-(4'-chloro)benzyloxy-6-hydroxy-7-methox...)
Affinity DataEC50:  5.00E+3nMAssay Description:Effect on blockade of Kv11.1 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50394744(CHEMBL2165822)
Affinity DataEC50:  5.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential assessed as reduction in tail current amplitude by conventional patch c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275941(CHEMBL513250 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataEC50:  6.50E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of human ERG by IonWorks patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50596276(CHEMBL5207002)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114837(CHEMBL3609755)
Affinity DataEC50:  7.50E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50567108(CHEMBL4850904)
Affinity DataEC50:  7.70E+3nMAssay Description:Antagonist activity at human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50495958(CHEMBL3121684)
Affinity DataEC50:  7.94E+3nMAssay Description:Inhibition of human ERG by patch-clamp techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50376592(CHEMBL406931)
Affinity DataEC50:  8.00E+3nMAssay Description:Activation of human ERG1 isoform 1 expressed in Xenopus laevis oocytes assessed as shifting of voltage dependence of inactivation towards positive po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50182585(5-acetyl-7-(4'-bromo)benzyloxy-6-hydroxy-4-methoxy...)
Affinity DataEC50:  9.00E+3nMAssay Description:Effect on blockade of Kv11.1 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114805(CHEMBL3608384)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50114810(CHEMBL3609754)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM349513(US10207991, Ex. Cpd. No. 28 | US10611728, Example ...)
Affinity DataEC50:  9.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50496206(CHEMBL3125176)
Affinity DataEC50:  9.80E+3nMAssay Description:Binding affinity to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50517833(CHEMBL4472621)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275986(6-(2-acetyl-2,7-diazaspiro[4.5]decan-7-yl)-N-(2-am...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50446172(CHEMBL3108997 | US9518026, Example 24 | US9956214,...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275770(CHEMBL513568 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50595354(CHEMBL5186371)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of hERG incubated for 2 hrs by fluorescence polarization based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275885(6-(2-acetyl-2,8-diazaspiro[4.5]decan-8-yl)-N-(2-am...)
Affinity DataEC50:  1.01E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275985(6-(2-acetyl-2,7-diazaspiro[3.5]nonan-7-yl)-N-(2-am...)
Affinity DataEC50:  1.01E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50275984(6-(7-acetyl-2,7-diazaspiro[4.4]nonan-2-yl)-N-(2-am...)
Affinity DataEC50:  1.03E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase component GSC2(Saccharomyces cerevisiae)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50499725(CHEMBL3740963)
Affinity DataEC50:  1.20E+4nMAssay Description:Induction of dissociation of [3H]-dofetilide from Kv11.1 channel (unknown origin) assessed as dissociation rate expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50581623(CHEMBL5088467)
Affinity DataEC50:  1.27E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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