Compile Data Set for Download or QSAR
maximum 50k data
Found 2059 of ec50 data for polymerid = 2212
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602186(US11643436, Compound TM-9A)
Affinity DataEC50:  0.00100nMAssay Description:Forskolin can stimulate the release of cAMP from HEK293 cells with high expression of human κ (or μ, or δ)-opioid receptors. The κ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235813(US9359399, 27)
Affinity DataEC50: <0.00100nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50561764(CHEMBL4743180)
Affinity DataEC50:  0.00100nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50561762(CHEMBL4785966)
Affinity DataEC50:  0.00100nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235811(US9359399, 25)
Affinity DataEC50:  0.00270nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM393487(US9963460, 13)
Affinity DataEC50:  0.00280nMAssay Description:In a [3SS] GTPγS binding test, the opioid receptor agonist activity of test compounds based on a GTP-GDP exchange reaction was evaluated. In the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235785(CVD-0019439 | US9359399, 2)
Affinity DataEC50:  0.00300nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50561760(CHEMBL4791124)
Affinity DataEC50:  0.00300nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235815(US9359399, 31)
Affinity DataEC50:  0.00420nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50269287(CHEMBL4087151)
Affinity DataEC50:  0.00466nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235816(US9359399, 32)
Affinity DataEC50:  0.00500nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235792(US9359399, 36)
Affinity DataEC50:  0.00520nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430586(CHEMBL2338721)
Affinity DataEC50:  0.00610nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235818(US9359399, 35)
Affinity DataEC50:  0.00640nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430613(CHEMBL2338723)
Affinity DataEC50:  0.00700nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430612(CHEMBL2338724)
Affinity DataEC50:  0.00770nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602189(US11643436, Compound TM-26)
Affinity DataEC50:  0.00800nMAssay Description:Forskolin can stimulate the release of cAMP from HEK293 cells with high expression of human κ (or μ, or δ)-opioid receptors. The κ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50274347((2E)-N-[(5R,6R)-17-(cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataEC50:  0.00820nMAssay Description:Agonist activity at kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235789(US9359399, 28)
Affinity DataEC50:  0.00830nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235812(US9359399, 26)
Affinity DataEC50:  0.00830nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602184(US11643436, Compound TM-7)
Affinity DataEC50:  0.00900nMAssay Description:Forskolin can stimulate the release of cAMP from HEK293 cells with high expression of human κ (or μ, or δ)-opioid receptors. The κ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602188(US11643436, Compound TM-22B)
Affinity DataEC50:  0.00900nMAssay Description:Forskolin can stimulate the release of cAMP from HEK293 cells with high expression of human κ (or μ, or δ)-opioid receptors. The κ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430611(CHEMBL2338725)
Affinity DataEC50:  0.00980nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50561763(CHEMBL4756370)
Affinity DataEC50:  0.0100nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430622(CHEMBL2338747)
Affinity DataEC50:  0.0110nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235790(US9359399, 30)
Affinity DataEC50:  0.0116nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430587(CHEMBL2338720)
Affinity DataEC50:  0.0130nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235814(US9359399, 29)
Affinity DataEC50:  0.0145nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50598862(CHEMBL5178795)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at human KOR expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50561761(CHEMBL4760663)
Affinity DataEC50:  0.0160nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430601(CHEMBL2338753)
Affinity DataEC50:  0.0160nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235791(US9359399, 33)
Affinity DataEC50:  0.0165nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430619(CHEMBL2338750)
Affinity DataEC50:  0.0170nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50034553(CHEMBL3359804)
Affinity DataEC50:  0.0190nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by luminescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430585(CHEMBL2338722)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM235817(US9359399, 34)
Affinity DataEC50:  0.0208nMT: 2°CAssay Description:Mouse R1.G1 cells (ATCC, Manassas, Va.) were grown in suspension in high glucose-DMEM (Dulbecco's Modified Eagle's Medium, Cellgro, Herndon, Va.) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50269282(CHEMBL4082823)
Affinity DataEC50:  0.0222nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50269278(CHEMBL4103819)
Affinity DataEC50:  0.0250nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50325534(CHEMBL267495 | nalfurafine)
Affinity DataEC50:  0.0250nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50269278(CHEMBL4103819)
Affinity DataEC50:  0.0250nMAssay Description:Agonist activity at human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50269291(CHEMBL4064781)
Affinity DataEC50:  0.0257nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430621(CHEMBL2338748)
Affinity DataEC50:  0.0270nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602183(US11643436, Compound TM-5)
Affinity DataEC50:  0.0270nMAssay Description:Forskolin can stimulate the release of cAMP from HEK293 cells with high expression of human κ (or μ, or δ)-opioid receptors. The κ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50269292(CHEMBL4066058)
Affinity DataEC50:  0.0280nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by TR-FRET as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50269298(CHEMBL4077552)
Affinity DataEC50:  0.0283nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50269289(CHEMBL4080324)
Affinity DataEC50:  0.0288nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50430610(CHEMBL2338726)
Affinity DataEC50:  0.0290nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM309432((2S,3aS,4R,9bS)-12-(cyclopropylmethyl)- N-(3,4-dic...)
Affinity DataEC50:  0.0300nMAssay Description:Radioligand binding assays (screening and dose-displacement) use 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 μg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataEC50:  0.0300nMAssay Description:Agonist activity at human KOR expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by luminescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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