Affinity DataEC50: 0.110nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.170nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 0.240nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.470nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 0.710nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 0.820nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 2.07nMAssay Description:Agonist activity at mGLUR3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataEC50: 2.07nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
Affinity DataEC50: 2.10nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 4.58nMAssay Description:Agonist activity at human mGLUR3 assessed as inhibition of forskolin-stimulated cAMP production by cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.60nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.60nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 5.20nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 6.60nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 6.60nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 7.20nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 7.60nMAssay Description:Ability to displace [3H]LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.More data for this Ligand-Target Pair
Affinity DataEC50: 7.60nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Agonistic activity against Human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 31nMAssay Description:Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu3 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataEC50: 38nMAssay Description:Agonist activity at mGLUR3 in rat cerebral cortex assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Ability to displace [3H]LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataEC50: 38nMAssay Description:Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Evaluation of the functional effect on cAMP responses in RGT cells expressing human mGlu3 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical
Curated by ChEMBL
Taisho Pharmaceutical
Curated by ChEMBL
Affinity DataEC50: 45.4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
Affinity DataEC50: 48nMAssay Description:Agonist activity at human mGluR3 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair