Compile Data Set for Download or QSAR
maximum 50k data
Found 18 of ec50 data for polymerid = 7285
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212258(GS-4997 | Selonsertib)
Affinity DataEC50:  2nMAssay Description:Inhibition of ASK1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM394380((S)-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-(3-hydrox...)
Affinity DataEC50:  5.21nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212260(CHEMBL3954836)
Affinity DataEC50:  6.30nMAssay Description:Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212261(CHEMBL3946139)
Affinity DataEC50:  6.30nMAssay Description:Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM394379((S)-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-morpholin...)
Affinity DataEC50:  6.74nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM394381((S)-4-(4-cyclopropyl-1H-imidazol-1-yl)-5-(dimethyl...)
Affinity DataEC50:  7.12nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM162311(US10307427, Compound 2 | US9051313, 2)
Affinity DataEC50:  11.2nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212254(CHEMBL3975466)
Affinity DataEC50:  13nMAssay Description:Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM162310(US10307427, Compound 1 | US9051313, 1)
Affinity DataEC50:  13.2nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212256(CHEMBL3966978)
Affinity DataEC50:  16nMAssay Description:Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50560389(CHEMBL4744428)
Affinity DataEC50:  24nMAssay Description:Inhibition of ASK1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212262(CHEMBL3937245)
Affinity DataEC50:  32nMAssay Description:Inhibition of human ASK1 expressed in HEK293 cells assessed as inhibition of H2O2-induced JNK phosphorylation preincubated for 30 mins followed by H2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50237288(CHEMBL4073198)
Affinity DataEC50:  60nMAssay Description:In vitro inhibition of porcine Dipeptidylpeptidase II.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50237293(CHEMBL4093878)
Affinity DataEC50:  65nMAssay Description:Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50237289(CHEMBL4086119)
Affinity DataEC50:  99nMAssay Description:Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50237295(CHEMBL4081134)
Affinity DataEC50:  130nMAssay Description:Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50237294(CHEMBL4064613)
Affinity DataEC50:  140nMAssay Description:Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50237290(CHEMBL4084596)
Affinity DataEC50:  600nMAssay Description:Inhibition of ASK1 (unknown origin) assessed as reduction in JNK phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed