Found 108 of ec50 data for polymerid = 8284 
Affinity DataEC50: 10nMAssay Description:Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 31nMAssay Description:Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataEC50: 54nMAssay Description:Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 70nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 125nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 128nMAssay Description:Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
Affinity DataEC50: 210nMAssay Description:Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 240nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 490nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 490nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 680nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
Affinity DataEC50: 890nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 891nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 900nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 910nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.23E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.25E+3nMAssay Description:Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.32E+3nMAssay Description:Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.59E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.72E+3nMAssay Description:Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+3nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.04E+3nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.60E+3nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.63E+3nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.70E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.88E+3nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.90E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.90E+3nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.50E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.72E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.10E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.10E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 6.17E+3nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair
Affinity DataEC50: 6.60E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 6.86E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Affinity DataEC50: 7.20E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 7.40E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Affinity DataEC50: 7.80E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 8.00E+3nMAssay Description:Agonist activity in rat at Metabotropic glutamate receptor 8 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 8.10E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 8.30E+3nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 9.17E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu8 receptor expressed in HEK293 cells assessed as glutamate-induced GIRK channel-mediated thallium f...More data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
