Compile Data Set for Download or QSAR
maximum 50k data
Found 2922 of ic50 data for polymerid = 1601,50000539,507
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194684(4-methyl-N-(2-methyl-3-4-methyl-N-(2-methyl-3-(2-(...)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301603((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194688(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301619((S)-3-((S)-1-(4-(5-(2-aminopyrimidin-4-yl)-1H-benz...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301604((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301624((S)-4-methyl-N(S)-4-methyl-N-(naphthalen-1-yl)-3-(...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM14949(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Lck by HTRF assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13271(BMS-354825 2-Heteroarylamino-thiazole Analog 12p |...)
Affinity DataIC50: <0.200nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13277(BMS-354825 2-Heteroarylamino-thiazole Analog 12v |...)
Affinity DataIC50:  0.200nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301607((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM14949(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194668(4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301605((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM14949(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Affinity DataIC50:  0.200nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301594(3-(1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-ylam...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301594(3-(1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-ylam...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  0.270nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.280nMAssay Description:Binding affinity to human LCK using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13262(BMS-354825 2-Heteroarylamino-thiazole Analog 12g |...)
Affinity DataIC50:  0.300nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26381(1-N-[3-fluoro-5-(trifluoromethyl)benzene]-4-methyl...)
Affinity DataIC50:  0.300nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50305129(6-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194694(CHEMBL427233 | N-(2,3-dihydro-1H-inden-4-yl)-4-met...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194691(CHEMBL212128 | N-(4-methyl-3-(2-(methylamino)quina...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.400nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26367(Aminoquinazoline amide, 35 | N-[3-(2-aminoquinazol...)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of lck inaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301618((S)-3-((S)-1-(4-(5-(3-ethyl-2-oxoimidazolidin-1-yl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194678(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194686(1-(2-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)b...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301588((S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidi...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194670(3-(2-aminoquinazolin-6-yl)-4-chloro-N-(3-(trifluor...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50305140(7-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50305119(7-(2-(dimethylamino)ethoxy)-2-(4-hydroxyphenyl)-9,...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50301608(CHEMBL566507 | ethyl 2-((S)-2-((S)-1-(4-(1H-benzo[...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13357(CHEMBL312933 | N-(2-chloro-6-methylphenyl)-2-({6-[...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13273(2-(6-(3-(1H-Imidazol-1-yl)propylamino)pyridin-2-yl...)
Affinity DataIC50: <0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194683(CHEMBL212953 | N-(2-(2-(diethylamino)acetamido)-5-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194671(4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194681(CHEMBL215019 | N-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13266(BMS-354825 2-Heteroarylamino-thiazole Analog 12k |...)
Affinity DataIC50:  0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13272(BMS-354825 2-Heteroarylamino-thiazole Analog 12q |...)
Affinity DataIC50:  0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194690(2-fluoro-4-methyl-5-(2-(methylamino)quinazolin-6-y...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13274(BMS-354825 2-Heteroarylamino-thiazole Analog 12s |...)
Affinity DataIC50:  0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13357(CHEMBL312933 | N-(2-chloro-6-methylphenyl)-2-({6-[...)
Affinity DataIC50:  0.5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26366(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)
Affinity DataIC50: <0.508nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM538621(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Affinity DataIC50: <0.508nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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