Compile Data Set for Download or QSAR
maximum 50k data
Found 3187 of ic50 data for polymerid = 2212
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50195673(CHEMBL267027 | N-cyclopropylmethyl-14beta-[3'-(4'-...)
Affinity DataIC50:  0.00300nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50195666(CHEMBL443311 | N-cyclopropylmethyl-14beta-[3'-(4'-...)
Affinity DataIC50:  0.00600nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0180nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50045179((R)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-pyrrolidi...)
Affinity DataIC50:  0.0200nMAssay Description:Agonistic activity at kappa opioid receptor of rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50045192(4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3,6-dihydro-...)
Affinity DataIC50:  0.0400nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0410nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0410nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50010532(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataIC50:  0.0600nMAssay Description:Evaluated for inhibitory activity against Opioid receptor kappa 1 of rabbit vas deferens (RVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM209923(5'-Guanidinonaltrindole (5'-GNTI))
Affinity DataIC50:  0.0700nMAssay Description:For antagonist experiments, protein was preincubated with test compounds for 15 min prior to the addition of 100 nM U69,593 and [35S]GTPγS. Reac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50000293(2-(3,4-Dichloro-phenyl)-1-(7-pyrrolidin-1-ylmethyl...)
Affinity DataIC50:  0.100nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50000293(2-(3,4-Dichloro-phenyl)-1-(7-pyrrolidin-1-ylmethyl...)
Affinity DataIC50:  0.100nMAssay Description:Opioid receptor kappa 1 agonist potency was determined in vitro using rabbit vas deferens (LVD) preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50195656(14beta-4'-Chlorocinnamoylaminodihydronormorphinone...)
Affinity DataIC50:  0.100nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50000293(2-(3,4-Dichloro-phenyl)-1-(7-pyrrolidin-1-ylmethyl...)
Affinity DataIC50:  0.100nMAssay Description:In vitro kappa-opioid receptor agonist activity in isolated rabbit vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50040123(CHEMBL438223 | HTry-Gly-Gly-Phe-Leu-Arg-Arg-lle-Ar...)
Affinity DataIC50:  0.110nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in mouse HN9.10 cell membranes incubated for 2 hrs by liquid scintillation counting based radiol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50001107(2-(3,4-Dichloro-phenyl)-1-(5-hydroxy-1-pyrrolidin-...)
Affinity DataIC50:  0.110nMAssay Description:In vitro kappa-opioid receptor agonist activity in isolated rabbit vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50000288((1-{1-[2-(3,4-Dichloro-phenyl)-acetyl]-piperidin-2...)
Affinity DataIC50:  0.120nMAssay Description:Opioid receptor kappa 1 agonist potency of the compound was determined in vitro using rabbit vas deferens(LVD) preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50558721(CHEMBL4784791)
Affinity DataIC50:  0.132nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in mouse HN9.10 cell membranes incubated for 2 hrs by liquid scintillation counting based radiol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM214798(Dynorphin A (1-17) | YGGFLRRIRPKLK)
Affinity DataIC50:  0.148nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in mouse HN9.10 cell membranes incubated for 2 hrs by liquid scintillation counting based radiol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50010704(CHEMBL216640 | Dyn A(1-11)-NH2 | Dynorphin A analo...)
Affinity DataIC50:  0.155nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in mouse HN9.10 cell membranes incubated for 2 hrs by liquid scintillation counting based radiol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM581036(RFCX0139-43 | US11492374, ID 17)
Affinity DataIC50:  0.157nMAssay Description:The measurement of opioid receptor binding affinity was conducted using a radioligand binding assay on the membranes prepared from HEK293 cells (huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50000271(1-{1-[2-(3,4-Dichloro-phenyl)-acetyl]-piperidin-2-...)
Affinity DataIC50:  0.200nMAssay Description:Opioid receptor kappa 1 agonist potency of the compound was determined in vitro using rabbit vas deferens(LVD) preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50280147(1-[4-Acetyl-2-((S)-3-hydroxy-pyrrolidin-1-ylmethyl...)
Affinity DataIC50:  0.220nMAssay Description:Agonistic activity at kappa opioid receptor of rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50340646(CHEMBL4159127)
Affinity DataIC50:  0.220nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 assessed as inhibition forskolin-induced cAMP accumulation after 15 mins by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM581037(RFCX0139-45 | US11492374, ID 18)
Affinity DataIC50:  0.253nMAssay Description:The measurement of opioid receptor binding affinity was conducted using a radioligand binding assay on the membranes prepared from HEK293 cells (huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM581034(US11492374, ID 13)
Affinity DataIC50:  0.255nMAssay Description:The measurement of opioid receptor binding affinity was conducted using a radioligand binding assay on the membranes prepared from HEK293 cells (huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50531921(CHEMBL4544914 | US10676469, Compound 148 | US11124...)
Affinity DataIC50:  0.260nMAssay Description:Antagonist activity at GAL4-VP16-fused KOR (unknown origin) expressed in human U2OS cells co-expressing Tango-OPRK1-BLA assessed as inhibition of U-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50045186(4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3-methoxycar...)
Affinity DataIC50:  0.280nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50195659(CHEMBL217395 | N-cyclopropylmethyl-14beta-[3'-(4'-...)
Affinity DataIC50:  0.290nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  0.300nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50045193(4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3-oxo-pyrrol...)
Affinity DataIC50:  0.340nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50195663(CHEMBL217658 | N-cyclopropylmethyl-14beta-[2'-(4''...)
Affinity DataIC50:  0.340nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50045196(4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3-hydroxy-py...)
Affinity DataIC50:  0.340nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50039101(2-(3,4-Dichloro-phenyl)-1-[4-(3-hydroxy-pyrrolidin...)
Affinity DataIC50:  0.390nMAssay Description:In vitro kappa-opioid receptor agonist activity in isolated rabbit vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM581035(US11492374, ID 14)
Affinity DataIC50:  0.398nMAssay Description:The measurement of opioid receptor binding affinity was conducted using a radioligand binding assay on the membranes prepared from HEK293 cells (huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50045189(1-{4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-pyrrolidin...)
Affinity DataIC50:  0.420nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50195675(CHEMBL217102 | N-cyclopropylmethyl-14beta-[4'-(4''...)
Affinity DataIC50:  0.440nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM209922(6'-Guanidinonaltrindole (6'-GNTI))
Affinity DataIC50:  0.440nMAssay Description:For antagonist experiments, protein was preincubated with test compounds for 15 min prior to the addition of 100 nM U69,593 and [35S]GTPγS. Reac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM209921(Norbinaltorphimine (nor-BNI))
Affinity DataIC50:  0.460nMAssay Description:For antagonist experiments, protein was preincubated with test compounds for 15 min prior to the addition of 100 nM U69,593 and [35S]GTPγS. Reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50039104((SS)-2-(3,4-Dichloro-phenyl)-1-[4-(3-hydroxy-pyrro...)
Affinity DataIC50:  0.470nMAssay Description:In vitro kappa-opioid receptor agonist activity in isolated rabbit vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM156516(US10118915, Compound 303 | US9682966, 303)
Affinity DataIC50:  0.5nMT: 2°CAssay Description:The cell line for the OPRK1 antagonist assay stably expresses the following elements. The carboxy terminus of the OPRK1 receptor has a 7 amino acid l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM156523(US10118915, Compound 309 | US9682966, 309)
Affinity DataIC50:  0.5nMAssay Description:Well-known assay for kappa opioid receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM156516(US10118915, Compound 303 | US9682966, 303)
Affinity DataIC50:  0.5nMAssay Description:Well-known assay for kappa opioid receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50130561((R)-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dime...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM156523(US10118915, Compound 309 | US9682966, 309)
Affinity DataIC50:  0.5nMT: 2°CAssay Description:The cell line for the OPRK1 antagonist assay stably expresses the following elements. The carboxy terminus of the OPRK1 receptor has a 7 amino acid l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50531915(CHEMBL4440683 | US10676469, Compound 144 | US11124...)
Affinity DataIC50:  0.530nMAssay Description:Antagonist activity at GAL4-VP16-fused KOR (unknown origin) expressed in human U2OS cells co-expressing Tango-OPRK1-BLA assessed as inhibition of U-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50586821(CHEMBL5089012)
Affinity DataIC50:  0.537nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in mouse HN9.10 cells by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50558711(CHEMBL4754961)
Affinity DataIC50:  0.550nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in mouse HN9.10 cell membranes incubated for 2 hrs by liquid scintillation counting based radiol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50531910(CHEMBL4576339)
Affinity DataIC50:  0.590nMAssay Description:Antagonist activity at GAL4-VP16-fused KOR (unknown origin) expressed in human U2OS cells co-expressing Tango-OPRK1-BLA assessed as inhibition of U-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50195676(CHEMBL217479 | N-cyclopropylmethyl-14beta-[4'-(4''...)
Affinity DataIC50:  0.590nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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