TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human HGK using MBP as substrate assessed as residual activity by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 0.348nMAssay Description:Inhibition of human HGK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human HGK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MAP4K4 (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of MAP4K4 (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal GST-tagged HGK (1 to 328 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataKi: 3.66nM IC50: 3.11nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.11nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of MAP4K4 (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of MAP4K4 (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of MAP4K4 (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataKi: 4.61nM IC50: 3.88nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 4.05nMAssay Description:The MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 uM, 10 mM MgAcetate and [gamma-33P-ATP] (specific activity and concentration as r...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 4.10nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 4.46nMAssay Description:The MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 uM, 10 mM MgAcetate and [gamma-33P-ATP] (specific activity and concentration as r...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 4.72nMAssay Description:The MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 uM, 10 mM MgAcetate and [gamma-33P-ATP] (specific activity and concentration as r...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataKi: 2.20nM IC50: 5.84nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataKi: 7.79nM IC50: 5.94nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system at physiological AT...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:The required volume of the 50× stock of test compound was added to the assay before a reaction mix containing the enzyme and substrate was added. The...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:The required volume of the 50× stock of test compound was added to the assay before a reaction mix containing the enzyme and substrate was added. The...More data for this Ligand-Target Pair