Compile Data Set for Download or QSAR
maximum 50k data
Found 47 of ic50 data for polymerid = 4928
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM86068(PPC)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50139137(CHEMBL3759162)
Affinity DataIC50:  6.37E+3nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50594668(CHEMBL5174712)
Affinity DataIC50:  7.84E+3nMAssay Description:Inhibition of human PON1 using paraoxon as a substrate by regression analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144692(CHEMBL3759251)
Affinity DataIC50:  8.76E+3nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50454598(CHEMBL4215208)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144693(CHEMBL3758983)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50139133(CHEMBL3759178)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50139135(CHEMBL3759775)
Affinity DataIC50:  2.37E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144739(CHEMBL3759516)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50139132(CHEMBL1462074)
Affinity DataIC50:  3.14E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50139134(CHEMBL3758686)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50001839(CHEMBL428647 | PACLITAXEL | taxol)
Affinity DataKi:  1.65E+4nM IC50:  4.20E+4nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM243044((2-Bromo-4,5-dimethoxyphenyl)(2,3-dibromo-5,6-dime...)
Affinity DataIC50:  1.23E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM243045((3-Bromo-4,5-dimethoxyphenyl)(2,3-dibromo-5,6-dime...)
Affinity DataIC50:  1.25E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM92331(Lornoxicam)
Affinity DataKi:  9.00E+3nM ΔG°:  -28.8kJ/mole IC50:  1.36E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM243043((2,3-dibromo-5,6-dimethoxyphenyl)(3,4-dimethoxyphe...)
Affinity DataIC50:  1.74E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50316126(Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...)
Affinity DataKi:  8.60E+4nM IC50:  1.80E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM10860(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Affinity DataKi:  3.40E+5nM IC50:  1.90E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  9.70E+4nM ΔG°:  -22.9kJ/mole IC50:  1.95E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataKi:  1.31E+5nM IC50:  2.26E+5nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144690(CHEMBL3759001)
Affinity DataIC50:  2.38E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM82185(Sulfosalazine, 3)
Affinity DataKi:  5.70E+5nM IC50:  2.60E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50139136(CHEMBL3759337)
Affinity DataIC50:  3.17E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM92332(Tenoxicam)
Affinity DataKi:  3.06E+5nM ΔG°:  -20.1kJ/mole IC50:  3.40E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM25902(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
Affinity DataKi:  7.02E+5nM IC50:  3.60E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144740(CHEMBL3758357)
Affinity DataIC50:  5.64E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144738(CHEMBL3758838)
Affinity DataIC50:  6.26E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144691(CHEMBL3759697)
Affinity DataIC50:  6.27E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataKi:  2.91E+5nM IC50:  6.65E+5nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM243048((3-Bromo-4,5-dihydroxyphenyl)(2,3-dibromo-5,6-dihy...)
Affinity DataIC50:  7.01E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  7.43E+5nM IC50:  8.00E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM243046((2,3-Dibromo-5,6-dihydroxyphenyl)(3,4-dihydroxyphe...)
Affinity DataIC50:  8.32E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM243047((2-Bromo-4,5-dihydroxyphenyl)(2,3-dibromo-5,6-dihy...)
Affinity DataIC50:  1.11E+6nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM243042((2,3-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanon...)
Affinity DataIC50:  1.21E+6nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM10868(1,3,4-Thiadiazole-2-sulfonamide, 6 | 1,3,4-thiadia...)
Affinity DataKi:  2.00E+6nM IC50:  1.24E+6nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50127646(CHEMBL42577 | Phosphoric acid 4-amino-phenyl ester...)
Affinity DataIC50:  1.28E+6nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  8.05E+5nM ΔG°:  -17.7kJ/mole IC50:  1.64E+6nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144742(CHEMBL3758332)
Affinity DataIC50:  2.06E+6nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM14675(CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...)
Affinity DataIC50:  3.25E+6nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50127647(CHEMBL296745 | Phosphoric acid diethyl ester pheny...)
Affinity DataIC50:  3.27E+6nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50144741(CHEMBL3760112)
Affinity DataIC50:  3.33E+6nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Affinity DataKi:  1.30E+7nM ΔG°:  -10.8kJ/mole IC50:  6.23E+6nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM92333(Lincomycine)
Affinity DataKi:  1.11E+7nM ΔG°:  -11.2kJ/mole IC50:  1.30E+7nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM24514(4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...)
Affinity DataIC50:  1.85E+7nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
In£N£

Curated by ChEMBL
LigandPNGBDBM189358(Asta Z 4942 | Ifosfamide | Iphosphamide | N,3-bis(...)
Affinity DataKi:  8.97E+6nM IC50:  2.33E+7nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed