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Compile Data Set for Download or QSAR

Found 241 hits of ic50 data for polymerid = 4974   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50391109
PNG
(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Show SMILES [O-][V]([O-])([O-])=O
Show InChI InChI=1S/4O.V/q;3*-1;
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n/an/a 16n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of LAR (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296375
PNG
((3S)-6-[4-(2,2-Dimethyl-1,3-dithiolan-4-yl)butylca...)
Show SMILES CC1(C)SCC(CCCCC(=O)Nc2ccc3CO[C@@H](Cc3c2)C(O)=O)S1
Show InChI InChI=1S/C20H27NO4S2/c1-20(2)26-12-16(27-20)5-3-4-6-18(22)21-15-8-7-13-11-25-17(19(23)24)10-14(13)9-15/h7-9,16-17H,3-6,10-12H2,1-2H3,(H,21,22)(H,23,24)/t16?,17-/m0/s1
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n/an/a 380n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296376
PNG
((3S)-7-[4-(2,2-Dimethyl-1,3-dithiolan-4-yl)butylca...)
Show SMILES CC1(C)SCC(CCCCC(=O)Nc2ccc3C[C@H](OCc3c2)C(O)=O)S1
Show InChI InChI=1S/C20H27NO4S2/c1-20(2)26-12-16(27-20)5-3-4-6-18(22)21-15-8-7-13-10-17(19(23)24)25-11-14(13)9-15/h7-9,16-17H,3-6,10-12H2,1-2H3,(H,21,22)(H,23,24)/t16?,17-/m0/s1
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n/an/a 382n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326165
PNG
(CHEMBL1241315 | oxalylaminobenzoic acid)
Show SMILES CCc1cc(C[C@H]2NC(=O)CN(CCCCOc3cccc(O)c3C(=O)OC)C2=O)ccc1N(C(=O)C(O)=O)c1ccccc1C(O)=O
Show InChI InChI=1S/C34H35N3O11/c1-3-21-17-20(13-14-24(21)37(31(41)33(44)45)25-10-5-4-9-22(25)32(42)43)18-23-30(40)36(19-28(39)35-23)15-6-7-16-48-27-12-8-11-26(38)29(27)34(46)47-2/h4-5,8-14,17,23,38H,3,6-7,15-16,18-19H2,1-2H3,(H,35,39)(H,42,43)(H,44,45)/t23-/m1/s1
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n/an/a 410n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50079855
PNG
((R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)Oc1c(Br)cc(cc1Br)-c1c2c3ccccc3oc2c(Br)c2ccccc12
Show InChI InChI=1S/C31H19Br3O4/c32-22-15-18(16-23(33)29(22)38-25(31(35)36)14-17-8-2-1-3-9-17)26-19-10-4-5-11-20(19)28(34)30-27(26)21-12-6-7-13-24(21)37-30/h1-13,15-16,25H,14H2,(H,35,36)/t25-/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested in vitro for the inhibitory activity against LAR (human Protein-tyrosine phosphatase F)


J Med Chem 42: 3199-202 (1999)


Article DOI: 10.1021/jm990260v
BindingDB Entry DOI: 10.7270/Q2DF6QCQ
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296374
PNG
((3S)-7-[2-(2,2-Dimethyl-1,3-dithiolan-4-yl)ethylca...)
Show SMILES CC1(C)SCC(CCC(=O)Nc2ccc3C[C@H](OCc3c2)C(O)=O)S1
Show InChI InChI=1S/C18H23NO4S2/c1-18(2)24-10-14(25-18)5-6-16(20)19-13-4-3-11-8-15(17(21)22)23-9-12(11)7-13/h3-4,7,14-15H,5-6,8-10H2,1-2H3,(H,19,20)(H,21,22)/t14?,15-/m0/s1
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n/an/a 458n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296373
PNG
((3S)-6-[2-(2,2-Dimethyl-1,3-dithiolan-4-yl)ethylca...)
Show SMILES CC1(C)SCC(CCC(=O)Nc2ccc3CO[C@@H](Cc3c2)C(O)=O)S1
Show InChI InChI=1S/C18H23NO4S2/c1-18(2)24-10-14(25-18)5-6-16(20)19-13-4-3-11-9-23-15(17(21)22)8-12(11)7-13/h3-4,7,14-15H,5-6,8-10H2,1-2H3,(H,19,20)(H,21,22)/t14?,15-/m0/s1
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n/an/a 493n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296372
PNG
((3S)-7-[3-(2-Thienyl)propylcarboxamido]-isochroman...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCc3cccs3)cc2CO1
Show InChI InChI=1S/C18H19NO4S/c20-17(5-1-3-15-4-2-8-24-15)19-14-7-6-12-10-16(18(21)22)23-11-13(12)9-14/h2,4,6-9,16H,1,3,5,10-11H2,(H,19,20)(H,21,22)/t16-/m0/s1
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n/an/a 625n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50177318
PNG
(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Show SMILES CCCCCCCCCCCCCCc1ccc(cc1)C(=O)c1ccc2c(nocc12)-c1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C36H43NO5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-15-17-29(18-16-27)36(40)32-24-23-31-33(32)25-42-37-35(31)28-19-21-30(22-20-28)41-26-34(38)39/h15-25H,2-14,26H2,1H3,(H,38,39)
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n/an/a 690n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against LAR protein tyrosine phosphatase


Bioorg Med Chem Lett 16: 499-502 (2005)


Article DOI: 10.1016/j.bmcl.2005.10.062
BindingDB Entry DOI: 10.7270/Q2319VFG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296371
PNG
((3S)-6-[3-(2-Thienyl)propylcarboxamido]-isochroman...)
Show SMILES OC(=O)[C@@H]1Cc2cc(NC(=O)CCCc3cccs3)ccc2CO1
Show InChI InChI=1S/C18H19NO4S/c20-17(5-1-3-15-4-2-8-24-15)19-14-7-6-12-11-23-16(18(21)22)10-13(12)9-14/h2,4,6-9,16H,1,3,5,10-11H2,(H,19,20)(H,21,22)/t16-/m0/s1
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n/an/a 765n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50262987
PNG
(CHEMBL506661 | Illudalic acid)
Show SMILES CC1(C)Cc2c(C1)c1C(=O)OC(O)Cc1c(C=O)c2O
Show InChI InChI=1S/C15H16O5/c1-15(2)4-8-9(5-15)13(18)10(6-16)7-3-11(17)20-14(19)12(7)8/h6,11,17-18H,3-5H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR


Bioorg Med Chem 16: 7399-409 (2008)


Article DOI: 10.1016/j.bmc.2008.06.014
BindingDB Entry DOI: 10.7270/Q2PC325T
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326151
PNG
(8-(2-Methylthiazol-4-yl)dibenzo[b,d]furan-4-carbox...)
Show SMILES Cc1ccc(cc1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O
Show InChI InChI=1S/C23H15NO3S/c1-13-5-7-14(8-6-13)22-24-19(12-28-22)15-9-10-20-18(11-15)16-3-2-4-17(23(25)26)21(16)27-20/h2-12H,1H3,(H,25,26)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50079856
PNG
(CHEMBL108721 | [2,6-Dibromo-4-(6-bromo-benzo[b]nap...)
Show SMILES OC(=O)COc1c(Br)cc(cc1Br)-c1c2c(sc3ccccc23)c(Br)c2ccccc12
Show InChI InChI=1S/C24H13Br3O3S/c25-16-9-12(10-17(26)23(16)30-11-19(28)29)20-13-5-1-2-6-14(13)22(27)24-21(20)15-7-3-4-8-18(15)31-24/h1-10H,11H2,(H,28,29)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested in vitro for the inhibitory activity against LAR (human Protein-tyrosine phosphatase F)


J Med Chem 42: 3199-202 (1999)


Article DOI: 10.1021/jm990260v
BindingDB Entry DOI: 10.7270/Q2DF6QCQ
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50263036
PNG
(3-Hydroxy-6-methoxy-8,8-dimethyl-1-oxo-1,3,4,7,8,9...)
Show SMILES COc1c2CC(C)(C)Cc2c2C(=O)OC(O)Cc2c1C=O
Show InChI InChI=1S/C16H18O5/c1-16(2)5-9-10(6-16)14(20-3)11(7-17)8-4-12(18)21-15(19)13(8)9/h7,12,18H,4-6H2,1-3H3
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n/an/a 1.53E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR


Bioorg Med Chem 16: 7399-409 (2008)


Article DOI: 10.1016/j.bmc.2008.06.014
BindingDB Entry DOI: 10.7270/Q2PC325T
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296382
PNG
((3S)-7-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxamid...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCC[C@@H]3CCSS3)cc2CO1
Show InChI InChI=1S/C18H23NO4S2/c20-17(4-2-1-3-15-7-8-24-25-15)19-14-6-5-12-10-16(18(21)22)23-11-13(12)9-14/h5-6,9,15-16H,1-4,7-8,10-11H2,(H,19,20)(H,21,22)/t15-,16+/m1/s1
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n/an/a 1.94E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326163
PNG
((E)-8-{2-[4-(2-Carboxyvinyl)phenyl]thiazol-4-yl}di...)
Show SMILES OC(=O)\C=C\c1ccc(cc1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O
Show InChI InChI=1S/C25H15NO5S/c27-22(28)11-6-14-4-7-15(8-5-14)24-26-20(13-32-24)16-9-10-21-19(12-16)17-2-1-3-18(25(29)30)23(17)31-21/h1-13H,(H,27,28)(H,29,30)/b11-6+
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n/an/a 1.98E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326164
PNG
((E)-8-{2-[3-(2-Carboxyvinyl)phenyl]thiazol-4-yl}di...)
Show SMILES OC(=O)\C=C\c1cccc(c1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O
Show InChI InChI=1S/C25H15NO5S/c27-22(28)10-7-14-3-1-4-16(11-14)24-26-20(13-32-24)15-8-9-21-19(12-15)17-5-2-6-18(25(29)30)23(17)31-21/h1-13H,(H,27,28)(H,29,30)/b10-7+
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n/an/a 2.07E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326156
PNG
(8-{2-[4-(Piperidin-1-yl)phenyl]thiazol-4-yl}dibenz...)
Show SMILES OC(=O)c1cccc2c3cc(ccc3oc12)-c1csc(n1)-c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C27H22N2O3S/c30-27(31)21-6-4-5-20-22-15-18(9-12-24(22)32-25(20)21)23-16-33-26(28-23)17-7-10-19(11-8-17)29-13-2-1-3-14-29/h4-12,15-16H,1-3,13-14H2,(H,30,31)
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n/an/a 2.07E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50262987
PNG
(CHEMBL506661 | Illudalic acid)
Show SMILES CC1(C)Cc2c(C1)c1C(=O)OC(O)Cc1c(C=O)c2O
Show InChI InChI=1S/C15H16O5/c1-15(2)4-8-9(5-15)13(18)10(6-16)7-3-11(17)20-14(19)12(7)8/h6,11,17-18H,3-5H2,1-2H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase a...


J Nat Prod 82: 3386-3393 (2019)


Article DOI: 10.1021/acs.jnatprod.9b00663
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50262987
PNG
(CHEMBL506661 | Illudalic acid)
Show SMILES CC1(C)Cc2c(C1)c1C(=O)OC(O)Cc1c(C=O)c2O
Show InChI InChI=1S/C15H16O5/c1-15(2)4-8-9(5-15)13(18)10(6-16)7-3-11(17)20-14(19)12(7)8/h6,11,17-18H,3-5H2,1-2H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase a...


J Nat Prod 82: 3386-3393 (2019)


Article DOI: 10.1021/acs.jnatprod.9b00663
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326162
PNG
(8-[2-(3-Iodophenyl)thiazol-4-yl]dibenzo[b,d]furan-...)
Show SMILES OC(=O)c1cccc2c3cc(ccc3oc12)-c1csc(n1)-c1cccc(I)c1
Show InChI InChI=1S/C22H12INO3S/c23-14-4-1-3-13(9-14)21-24-18(11-28-21)12-7-8-19-17(10-12)15-5-2-6-16(22(25)26)20(15)27-19/h1-11H,(H,25,26)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326158
PNG
(8-{2-[4-(2,6-Dimethylmorpholino)phenyl]thiazol-4-y...)
Show SMILES CC1CN(CC(C)O1)c1ccc(cc1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O
Show InChI InChI=1S/C28H24N2O4S/c1-16-13-30(14-17(2)33-16)20-9-6-18(7-10-20)27-29-24(15-35-27)19-8-11-25-23(12-19)21-4-3-5-22(28(31)32)26(21)34-25/h3-12,15-17H,13-14H2,1-2H3,(H,31,32)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296380
PNG
((3S)-7-[4-(1,2-Dithiolan-3-yl)butylcarboxamido]-is...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCCC3CCSS3)cc2CO1
Show InChI InChI=1S/C18H23NO4S2/c20-17(4-2-1-3-15-7-8-24-25-15)19-14-6-5-12-10-16(18(21)22)23-11-13(12)9-14/h5-6,9,15-16H,1-4,7-8,10-11H2,(H,19,20)(H,21,22)/t15?,16-/m0/s1
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n/an/a 2.38E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296381
PNG
((3S)-6-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxamid...)
Show SMILES OC(=O)[C@@H]1Cc2cc(NC(=O)CCCC[C@@H]3CCSS3)ccc2CO1
Show InChI InChI=1S/C18H23NO4S2/c20-17(4-2-1-3-15-7-8-24-25-15)19-14-6-5-12-11-23-16(18(21)22)10-13(12)9-14/h5-6,9,15-16H,1-4,7-8,10-11H2,(H,19,20)(H,21,22)/t15-,16+/m1/s1
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n/an/a 2.39E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50099778
PNG
(4-Phenyl-[1,2]naphthoquinone | CHEMBL51447)
Show SMILES O=C1C=C(c2ccccc2)c2ccccc2C1=O
Show InChI InChI=1S/C16H10O2/c17-15-10-14(11-6-2-1-3-7-11)12-8-4-5-9-13(12)16(15)18/h1-10H
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n/an/a 2.49E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against recombinant human LAR using fluoreacein diphosphate (FDP) as a substrate


Bioorg Med Chem Lett 12: 1941-6 (2002)


Article DOI: 10.1016/s0960-894x(02)00331-1
BindingDB Entry DOI: 10.7270/Q2QZ2999
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326161
PNG
(8-[2-(4-Iodophenyl)thiazol-4-yl]dibenzo[b,d]furan-...)
Show SMILES OC(=O)c1cccc2c3cc(ccc3oc12)-c1csc(n1)-c1ccc(I)cc1
Show InChI InChI=1S/C22H12INO3S/c23-14-7-4-12(5-8-14)21-24-18(11-28-21)13-6-9-19-17(10-13)15-2-1-3-16(22(25)26)20(15)27-19/h1-11H,(H,25,26)
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n/an/a 2.65E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326153
PNG
(8-[2-(4-Aminophenyl)thiazol-4-yl]dibenzo[b,d]furan...)
Show SMILES Nc1ccc(cc1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O
Show InChI InChI=1S/C22H14N2O3S/c23-14-7-4-12(5-8-14)21-24-18(11-28-21)13-6-9-19-17(10-13)15-2-1-3-16(22(25)26)20(15)27-19/h1-11H,23H2,(H,25,26)
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n/an/a 2.69E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296379
PNG
((3S)-6-[4-(1,2-Dithiolan-3-yl)butylcarboxamido]-is...)
Show SMILES OC(=O)[C@@H]1Cc2cc(NC(=O)CCCCC3CCSS3)ccc2CO1
Show InChI InChI=1S/C18H23NO4S2/c20-17(4-2-1-3-15-7-8-24-25-15)19-14-6-5-12-11-23-16(18(21)22)10-13(12)9-14/h5-6,9,15-16H,1-4,7-8,10-11H2,(H,19,20)(H,21,22)/t15?,16-/m0/s1
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n/an/a 2.85E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326152
PNG
(8-[2-(4-Nitrophenyl)thiazol-4-yl]dibenzo[b,d]furan...)
Show SMILES OC(=O)c1cccc2c3cc(ccc3oc12)-c1csc(n1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H12N2O5S/c25-22(26)16-3-1-2-15-17-10-13(6-9-19(17)29-20(15)16)18-11-30-21(23-18)12-4-7-14(8-5-12)24(27)28/h1-11H,(H,25,26)
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n/an/a 2.87E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326157
PNG
(8-[2-(4-Morpholinophenyl)thiazol-4-yl]dibenzo[b,d]...)
Show SMILES OC(=O)c1cccc2c3cc(ccc3oc12)-c1csc(n1)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C26H20N2O4S/c29-26(30)20-3-1-2-19-21-14-17(6-9-23(21)32-24(19)20)22-15-33-25(27-22)16-4-7-18(8-5-16)28-10-12-31-13-11-28/h1-9,14-15H,10-13H2,(H,29,30)
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n/an/a 2.94E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326155
PNG
(8-{2-[4-(Pyrrolidin-1-yl)phenyl]thiazol-4-yl}diben...)
Show SMILES OC(=O)c1cccc2c3cc(ccc3oc12)-c1csc(n1)-c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C26H20N2O3S/c29-26(30)20-5-3-4-19-21-14-17(8-11-23(21)31-24(19)20)22-15-32-25(27-22)16-6-9-18(10-7-16)28-12-1-2-13-28/h3-11,14-15H,1-2,12-13H2,(H,29,30)
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n/an/a 2.99E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326159
PNG
(8-[2-(4-Carboxyphenyl)thiazol-4-yl]dibenzo[b,d]fur...)
Show SMILES OC(=O)c1ccc(cc1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O
Show InChI InChI=1S/C23H13NO5S/c25-22(26)13-6-4-12(5-7-13)21-24-18(11-30-21)14-8-9-19-17(10-14)15-2-1-3-16(23(27)28)20(15)29-19/h1-11H,(H,25,26)(H,27,28)
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n/an/a 3.25E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50409191
PNG
(CHEMBL365490)
Show SMILES OC(=O)[C@H](Cc1ccccc1)Oc1ccc(cc1)-c1ccc(cc1)-c1c(Cc2ccccc2)oc2ccccc12
Show InChI InChI=1S/C36H28O4/c37-36(38)34(24-26-11-5-2-6-12-26)39-30-21-19-28(20-22-30)27-15-17-29(18-16-27)35-31-13-7-8-14-32(31)40-33(35)23-25-9-3-1-4-10-25/h1-22,34H,23-24H2,(H,37,38)/t34-/m0/s1
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n/an/a 3.25E+3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
in vitro inhibitory activity against LAR


J Med Chem 43: 1293-310 (2001)


Article DOI: 10.1021/jm990560c
BindingDB Entry DOI: 10.7270/Q2W958FT
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296391
PNG
((2S)-3-(4-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxa...)
Show SMILES CCO[C@@H](Cc1ccc(NC(=O)CCCC[C@@H]2CCSS2)cc1)C(O)=O
Show InChI InChI=1S/C19H27NO4S2/c1-2-24-17(19(22)23)13-14-7-9-15(10-8-14)20-18(21)6-4-3-5-16-11-12-25-26-16/h7-10,16-17H,2-6,11-13H2,1H3,(H,20,21)(H,22,23)/t16-,17+/m1/s1
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n/an/a 3.29E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326160
PNG
(8-[2-(3,5-Dibromo-4-(1-carboxy-2-phenylethoxy)phen...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)C(=O)c1c(Br)cc(cc1Br)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O
Show InChI InChI=1S/C32H19Br2NO6S/c33-23-13-18(14-24(34)27(23)28(36)22(32(39)40)11-16-5-2-1-3-6-16)30-35-25(15-42-30)17-9-10-26-21(12-17)19-7-4-8-20(31(37)38)29(19)41-26/h1-10,12-15,22H,11H2,(H,37,38)(H,39,40)/t22-/m0/s1
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n/an/a 3.57E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50326154
PNG
(8-{2-[4-(Dimethylamino)phenyl]thiazol-4-yl}dibenzo...)
Show SMILES CN(C)c1ccc(cc1)-c1nc(cs1)-c1ccc2oc3c(cccc3c2c1)C(O)=O
Show InChI InChI=1S/C24H18N2O3S/c1-26(2)16-9-6-14(7-10-16)23-25-20(13-30-23)15-8-11-21-19(12-15)17-4-3-5-18(24(27)28)22(17)29-21/h3-13H,1-2H3,(H,27,28)
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n/an/a 3.75E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR after 30 mins by spectrophotometry


Eur J Med Chem 45: 3709-18 (2010)


Article DOI: 10.1016/j.ejmech.2010.05.020
BindingDB Entry DOI: 10.7270/Q24Q7V6S
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50148911
PNG
((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Show InChI InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Universidad Aut£noma del Estado de Morelos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant LAR expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr


Eur J Med Chem 46: 2243-51 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.005
BindingDB Entry DOI: 10.7270/Q2FT8N4M
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296385
PNG
((3S)-6-{4-[(4R)-1,3-Dithian-4-yl]butylcarboxamido}...)
Show SMILES OC(=O)[C@@H]1Cc2cc(NC(=O)CCCC[C@@H]3CCSCS3)ccc2CO1
Show InChI InChI=1S/C19H25NO4S2/c21-18(4-2-1-3-16-7-8-25-12-26-16)20-15-6-5-13-11-24-17(19(22)23)10-14(13)9-15/h5-6,9,16-17H,1-4,7-8,10-12H2,(H,20,21)(H,22,23)/t16-,17+/m1/s1
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n/an/a 4.07E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296386
PNG
((3S)-7-{4-[(4R)-1,3-Dithian-4-yl]butylcarboxamido}...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCC[C@@H]3CCSCS3)cc2CO1
Show InChI InChI=1S/C19H25NO4S2/c21-18(4-2-1-3-16-7-8-25-12-26-16)20-15-6-5-13-10-17(19(22)23)24-11-14(13)9-15/h5-6,9,16-17H,1-4,7-8,10-12H2,(H,20,21)(H,22,23)/t16-,17+/m1/s1
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n/an/a 4.37E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296390
PNG
((2S)-3-(4-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxa...)
Show SMILES CO[C@@H](Cc1ccc(NC(=O)CCCC[C@@H]2CCSS2)cc1)C(O)=O
Show InChI InChI=1S/C18H25NO4S2/c1-23-16(18(21)22)12-13-6-8-14(9-7-13)19-17(20)5-3-2-4-15-10-11-24-25-15/h6-9,15-16H,2-5,10-12H2,1H3,(H,19,20)(H,21,22)/t15-,16+/m1/s1
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n/an/a 4.66E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296377
PNG
((3S)-6-[2-(2,2-Diphenyl-1,3-dithiolan-4-yl)ethylca...)
Show SMILES OC(=O)[C@@H]1Cc2cc(NC(=O)CCC3CSC(S3)(c3ccccc3)c3ccccc3)ccc2CO1
Show InChI InChI=1S/C28H27NO4S2/c30-26(29-23-12-11-19-17-33-25(27(31)32)16-20(19)15-23)14-13-24-18-34-28(35-24,21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-12,15,24-25H,13-14,16-18H2,(H,29,30)(H,31,32)/t24?,25-/m0/s1
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n/an/a 4.98E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296378
PNG
((3S)-7-[2-(2,2-Diphenyl-1,3-dithiolan-4-yl)ethylca...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCC3CSC(S3)(c3ccccc3)c3ccccc3)cc2CO1
Show InChI InChI=1S/C28H27NO4S2/c30-26(29-23-12-11-19-16-25(27(31)32)33-17-20(19)15-23)14-13-24-18-34-28(35-24,21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-12,15,24-25H,13-14,16-18H2,(H,29,30)(H,31,32)/t24?,25-/m0/s1
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n/an/a 5.06E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50290909
PNG
(CHEMBL4164960)
Show SMILES CCOc1cc(NS(C)(=O)=O)c(OCC)cc1CNC(=O)Nc1ccc(OCC)c(c1)C(=O)OC
Show InChI InChI=1S/C23H31N3O8S/c1-6-32-19-10-9-16(12-17(19)22(27)31-4)25-23(28)24-14-15-11-21(34-8-3)18(26-35(5,29)30)13-20(15)33-7-2/h9-13,26H,6-8,14H2,1-5H3,(H2,24,25,28)
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n/an/a 5.36E+3n/an/an/an/an/an/a



Qilu University of Technology (Shandong Academy of Sciences)

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged LAR D1 (1275 to 1613 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrate


Eur J Med Chem 144: 692-700 (2018)


Article DOI: 10.1016/j.ejmech.2017.12.064
BindingDB Entry DOI: 10.7270/Q23B62P2
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296389
PNG
((3S)-7-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxamid...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCC[C@@H]3CCSS3)cc2C(=O)O1
Show InChI InChI=1S/C18H21NO5S2/c20-16(4-2-1-3-13-7-8-25-26-13)19-12-6-5-11-9-15(17(21)22)24-18(23)14(11)10-12/h5-6,10,13,15H,1-4,7-9H2,(H,19,20)(H,21,22)/t13-,15+/m1/s1
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n/an/a 5.86E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296393
PNG
((2S)-2-Butoxy-3-(4-{4-[(3R)-1,2-dithiolan-3-yl]but...)
Show SMILES CCCCO[C@@H](Cc1ccc(NC(=O)CCCC[C@@H]2CCSS2)cc1)C(O)=O
Show InChI InChI=1S/C21H31NO4S2/c1-2-3-13-26-19(21(24)25)15-16-8-10-17(11-9-16)22-20(23)7-5-4-6-18-12-14-27-28-18/h8-11,18-19H,2-7,12-15H2,1H3,(H,22,23)(H,24,25)/t18-,19+/m1/s1
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n/an/a 5.86E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296370
PNG
((3S)-7-[4-(2-Thienyl)butylcarboxamido]-isochroman-...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCCc3cccs3)cc2CO1
Show InChI InChI=1S/C19H21NO4S/c21-18(6-2-1-4-16-5-3-9-25-16)20-15-8-7-13-11-17(19(22)23)24-12-14(13)10-15/h3,5,7-10,17H,1-2,4,6,11-12H2,(H,20,21)(H,22,23)/t17-/m0/s1
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n/an/a 5.91E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296392
PNG
((2S)-3-(4-{4-[(3R)-1,2-Dithiolan-3-yl]butylcarboxa...)
Show SMILES CCCO[C@@H](Cc1ccc(NC(=O)CCCC[C@@H]2CCSS2)cc1)C(O)=O
Show InChI InChI=1S/C20H29NO4S2/c1-2-12-25-18(20(23)24)14-15-7-9-16(10-8-15)21-19(22)6-4-3-5-17-11-13-26-27-17/h7-10,17-18H,2-6,11-14H2,1H3,(H,21,22)(H,23,24)/t17-,18+/m1/s1
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n/an/a 5.98E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296384
PNG
((3S)-7-{4-[(4S)-2-Oxoperhydrothieno-[3,4-d]imidazo...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCC[C@@H]3SCC4NC(=O)NC34)cc2CO1
Show InChI InChI=1S/C20H25N3O5S/c24-17(4-2-1-3-16-18-14(10-29-16)22-20(27)23-18)21-13-6-5-11-8-15(19(25)26)28-9-12(11)7-13/h5-7,14-16,18H,1-4,8-10H2,(H,21,24)(H,25,26)(H2,22,23,27)/t14?,15-,16-,18?/m0/s1
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n/an/a 6.47E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50282483
PNG
(CHEMBL4161709)
Show SMILES CCOc1cc(NS(C)(=O)=O)c(OCC)cc1CNC(=O)Nc1ccc(OCC)c(c1)C(=O)Nc1ccc(C)cc1
Show InChI InChI=1S/C29H36N4O7S/c1-6-38-25-14-13-22(16-23(25)28(34)31-21-11-9-19(4)10-12-21)32-29(35)30-18-20-15-27(40-8-3)24(33-41(5,36)37)17-26(20)39-7-2/h9-17,33H,6-8,18H2,1-5H3,(H,31,34)(H2,30,32,35)
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n/an/a 6.95E+3n/an/an/an/an/an/a



Qilu University of Technology (Shandong Academy of Sciences)

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged LAR D1 (1275 to 1613 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrate


Eur J Med Chem 144: 692-700 (2018)


Article DOI: 10.1016/j.ejmech.2017.12.064
BindingDB Entry DOI: 10.7270/Q23B62P2
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM50296388
PNG
((3S)-7-{4-[(4R)-2,2-Diphenyl-1,3-dithian-4-yl]buty...)
Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CCCC[C@@H]3CCSC(S3)(c3ccccc3)c3ccccc3)cc2CO1
Show InChI InChI=1S/C31H33NO4S2/c33-29(32-26-16-15-22-20-28(30(34)35)36-21-23(22)19-26)14-8-7-13-27-17-18-37-31(38-27,24-9-3-1-4-10-24)25-11-5-2-6-12-25/h1-6,9-12,15-16,19,27-28H,7-8,13-14,17-18,20-21H2,(H,32,33)(H,34,35)/t27-,28+/m1/s1
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n/an/a 7.03E+3n/an/an/an/an/an/a



Glenmark Research Center

Curated by ChEMBL


Assay Description
Inhibition of LAR


Eur J Med Chem 44: 3147-57 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.009
BindingDB Entry DOI: 10.7270/Q2FJ2GTG
More data for this
Ligand-Target Pair
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