Compile Data Set for Download or QSAR
maximum 50k data
Found 42 of ic50 data for polymerid = 50006479,50006479
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50575835(CHEMBL4878260)
Affinity DataIC50:  13nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
Affinity DataIC50:  25nMAssay Description:Concentration required to achieve 50% inhibition against 4-hydroxyphenylpyruvate dioxygenase from pig liver; (observed value)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50:  210nMAssay Description:Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux after 30 to 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50:  210nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  320nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50575838(CHEMBL4863360)
Affinity DataIC50:  398nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50575841(CHEMBL4864346)
Affinity DataIC50:  410nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50575839(CHEMBL4856222)
Affinity DataIC50:  467nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM27502(3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoq...)
Affinity DataIC50:  600nMAssay Description:Concentration required to achieve 50% inhibition against 4-hydroxyphenylpyruvate dioxygenase from pig liver; (observed value)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50575837(CHEMBL4863549)
Affinity DataIC50:  788nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50575836(CHEMBL4849043)
Affinity DataIC50:  830nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50575840(CHEMBL4856093)
Affinity DataIC50:  987nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50:  1.00E+3nMAssay Description:Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux after 30 mins by Fluo4-AM dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50291511(2-((E)-3-Biphenyl-4-yl-acryloylamino)-benzoic acid...)
Affinity DataIC50:  2.56E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM31773(ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50405913(CHEMBL4176916)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50405913(CHEMBL4176916)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50405912(CHEMBL4159037)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50:  4.50E+3nMAssay Description:Concentration required to achieve 50% inhibition against 4-Hydroxyphenylpyruvate dioxygenase (HPPD) from pig liver; (observed value)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50405910(CHEMBL4174768)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50405911(CHEMBL4167784)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50579155(CHEMBL4872096)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50579154(CHEMBL4873412)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50450500(CHEMBL4164465)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TRPM2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50446561(CHEMBL3110215)
Affinity DataIC50:  1.10E+4nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at TRPM2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50446559(CHEMBL3110213)
Affinity DataIC50:  4.90E+4nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50446560(CHEMBL3110214)
Affinity DataIC50:  5.10E+4nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50385713(CHEMBL23479)
Affinity DataIC50:  7.60E+4nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50446558(CHEMBL3110195)
Affinity DataIC50:  1.00E+5nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50446557(CHEMBL3110204)
Affinity DataIC50:  1.00E+5nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50324670(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  1.00E+5nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50446562(CHEMBL3110216)
Affinity DataIC50:  3.00E+5nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed