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Compile Data Set for Download or QSAR

Found 10 hits of ic50 data for polymerid = 50007406   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Meprin A subunit alpha


(Homo sapiens)
BDBM50455648
PNG
(CHEMBL4205925)
Show SMILES ONC(=O)CN(Cc1ccc(Cl)c(O)c1F)Cc1ccc(Cl)c(O)c1F
Show InChI InChI=1S/C16H14Cl2F2N2O4/c17-10-3-1-8(13(19)15(10)24)5-22(7-12(23)21-26)6-9-2-4-11(18)16(25)14(9)20/h1-4,24-26H,5-7H2,(H,21,23)
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 368n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay


J Med Chem 61: 4578-4592 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00330
BindingDB Entry DOI: 10.7270/Q2KS6V47
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50455676
PNG
(CHEMBL4209993)
Show SMILES ONC(=O)CN(Cc1ccc(F)c(O)c1F)Cc1ccc(F)c(O)c1F
Show InChI InChI=1S/C16H21N3O4S3.ClH/c1-18-6-8-19(9-7-18)11-13-4-2-3-5-15(13)25(20,21)14-10-16(24-12-14)26(17,22)23;/h2-5,10,12H,6-9,11H2,1H3,(H2,17,22,23);1H
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PubMed
n/an/a 626n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay


J Med Chem 61: 4578-4592 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00330
BindingDB Entry DOI: 10.7270/Q2KS6V47
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50455655
PNG
(CHEMBL4217178)
Show SMILES ONC(=O)CN(Cc1ccc2OCOc2c1)Cc1ccc2OCOc2c1
Show InChI InChI=1S/C18H18N2O6/c21-18(19-22)9-20(7-12-1-3-14-16(5-12)25-10-23-14)8-13-2-4-15-17(6-13)26-11-24-15/h1-6,22H,7-11H2,(H,19,21)
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UniChem
Article
PubMed
n/an/a 830n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of meprin alpha (unknown origin)


J Med Chem 61: 4578-4592 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00330
BindingDB Entry DOI: 10.7270/Q2KS6V47
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50455656
PNG
(CHEMBL4203115)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C#N)Cc1cccc(c1)C#N
Show InChI InChI=1S/C18H16N4O2/c19-9-14-3-1-5-16(7-14)11-22(13-18(23)21-24)12-17-6-2-4-15(8-17)10-20/h1-8,24H,11-13H2,(H,21,23)
UniProtKB/SwissProt

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PC sid
UniChem
Article
PubMed
n/an/a 1.47E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of meprin alpha (unknown origin)


J Med Chem 61: 4578-4592 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00330
BindingDB Entry DOI: 10.7270/Q2KS6V47
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50455682
PNG
(CHEMBL4206683)
Show SMILES ONC(=O)CN(Cc1ccc(Cl)cc1)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C19H18N2O3S2.ClH/c20-26(23,24)18-10-17(13-25-18)19(22)16-8-6-15(7-9-16)12-21-11-14-4-2-1-3-5-14;/h1-10,13,21H,11-12H2,(H2,20,23,24);1H
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Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay


J Med Chem 61: 4578-4592 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00330
BindingDB Entry DOI: 10.7270/Q2KS6V47
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
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n/an/a 3.29E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in S2 insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay


Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50240415
PNG
(CHEMBL4078433)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H18N2O7S/c1-26-14-5-7-15(8-6-14)27(24,25)19(11-16(20)18-23)10-12-3-2-4-13(9-12)17(21)22/h2-9,23H,10-11H2,1H3,(H,18,20)(H,21,22)
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 3.29E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay


J Med Chem 61: 4578-4592 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00330
BindingDB Entry DOI: 10.7270/Q2KS6V47
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50455674
PNG
(CHEMBL4217240)
Show SMILES COc1ccc(CN(CC(=O)NO)Cc2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C11H11NO5S3/c1-17-8-2-4-9(5-3-8)19(13,14)10-6-11(18-7-10)20(12,15)16/h2-7H,1H3,(H2,12,15,16)
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Article
PubMed
n/an/a 3.42E+3n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay


J Med Chem 61: 4578-4592 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00330
BindingDB Entry DOI: 10.7270/Q2KS6V47
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50455658
PNG
(CHEMBL4216076)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)Cc1cccc(c1)C(O)=O
Show InChI InChI=1S/C18H18N2O6/c21-16(19-26)11-20(9-12-3-1-5-14(7-12)17(22)23)10-13-4-2-6-15(8-13)18(24)25/h1-8,26H,9-11H2,(H,19,21)(H,22,23)(H,24,25)
UniProtKB/SwissProt

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PC sid
UniChem
Article
PubMed
n/an/a 1.61E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay


J Med Chem 61: 4578-4592 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00330
BindingDB Entry DOI: 10.7270/Q2KS6V47
More data for this
Ligand-Target Pair
Meprin A subunit alpha


(Homo sapiens)
BDBM50240414
PNG
(CHEMBL4105563)
Show SMILES ONC(=O)CN(Cc1cccc(c1)C(O)=O)S(=O)(=O)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H16N2O8S/c20-15(18-25)10-19(9-11-3-1-4-12(7-11)16(21)22)28(26,27)14-6-2-5-13(8-14)17(23)24/h1-8,25H,9-10H2,(H,18,20)(H,21,22)(H,23,24)
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CHEMBL
MMDB
PC cid
PC sid
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Article
PubMed
n/an/a 2.74E+4n/an/an/an/an/an/a



Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL


Assay Description
Inhibition of recombinant human meprin alpha expressed in S2 insect cells using Abz-YVADAPK(Dnp)G-OH as substrate by fluorescence assay


Bioorg Med Chem Lett 27: 2428-2431 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.012
BindingDB Entry DOI: 10.7270/Q2CR5WH0
More data for this
Ligand-Target Pair