Compile Data Set for Download or QSAR
maximum 50k data
Found 496 of ic50 data for polymerid = 50007454
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639724(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  3.22nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639875((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...)
Affinity DataIC50:  3.38nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639703(N-[6, 7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  3.56nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639763((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...)
Affinity DataIC50:  3.76nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639676(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  4.33nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639869(3-((6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4...)
Affinity DataIC50:  4.74nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639655(6,7-Dichloro-N-(2-fluoroethyl)-3-(1H-pyrazol-4-yl)...)
Affinity DataIC50:  4.91nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639685(N-((6,7-Dichloro-4-(cyanomethoxy)-3-(1H-pyrazol-4-...)
Affinity DataIC50:  5.11nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639781(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indazol-4-...)
Affinity DataIC50:  5.20nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639702(N-(6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl)...)
Affinity DataIC50:  5.67nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639874((S)—N-(5,6-Dichloro-8-ethoxy-9-(1H-pyrazol-4-...)
Affinity DataIC50:  6.14nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639734(2-((6,7-Dichloro-2-(5-methyl-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50:  6.77nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639879(3,4-Dichloro-1-(3-hydroxypropoxy)-10-(1H-pyrazol-4...)
Affinity DataIC50:  6.95nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639810(2-((6,7-Dichloro-2-(2-methoxyacetyl)-10-(1H-pyrazo...)
Affinity DataIC50:  7.20nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639768(N-(5,6-Dichloro-9-(1H-pyrazol-4-yl)-2,3-dihydro-1H...)
Affinity DataIC50:  7.69nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639870(6,7-Dichloro-9-(3-hydroxypropoxy)-2-methyl-10-(1H-...)
Affinity DataIC50:  7.89nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639811(US20230391786, Example 280)
Affinity DataIC50:  8.70nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639812(US20230391786, Example 281)
Affinity DataIC50:  8.90nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639728(22-[6, 7-Dichloro-1-[1-(2-hydroxy ethyl)triazol-4-...)
Affinity DataIC50:  8.93nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639813(US20230391786, Example 282)
Affinity DataIC50:  8.96nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639775((S)—N-(2-Acetamido-5,6-dichloro-9-(1H-pyrazol...)
Affinity DataIC50:  9.90nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM50582698(CHEMBL4448176)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cGASMore data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM50582698(CHEMBL4448176)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cGASMore data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM50582698(CHEMBL4448176)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length human cGAS expressed in Escherichia coli BL21 (DE3) incubated for 2 hrs in presence of ATP by RF-MS analysisMore data for this Ligand-Target Pair
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639871(2-((6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4...)
Affinity DataIC50:  10.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639657(3-((6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  10.3nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639718(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  10.4nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639814(US20230391786, Example 283)
Affinity DataIC50:  10.6nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639729(3-[[6,7-Dichloro-1-[1-(2-hydroxyethyl)triazol-4-yl...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639623(2-((6,7-Dichloro-2-(2-hydroxyacetyl)-10-(1H-pyrazo...)
Affinity DataIC50:  11.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639665(N-[[6,7-Dichloro-1-methyl-3-(1H-pyrazol-4-yl)indol...)
Affinity DataIC50:  11.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639711(5-[6,7-Dichloro-10-(1H-pyrazol-4-yl)-3,4-dihydro-1...)
Affinity DataIC50:  11.5nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639547(3,4-Dichloro-10-(1H-pyrazol-4-yl)-6,7,8,9-tetrahyd...)
Affinity DataIC50:  11.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639714(6,7-Dichloro-4-(2-fluoroethoxy)-3-(1H-pyrazol-4-yl...)
Affinity DataIC50:  11.8nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639756(N-[6,7-Dichloro-2-(2-hydroxyethyl)-3-(1H-pyrazol-4...)
Affinity DataIC50:  12.1nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639776((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...)
Affinity DataIC50:  12.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639878(2-((5,6-Dichloro-1-(hydroxymethyl)-9-(1H-pyrazol-4...)
Affinity DataIC50:  12.2nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639868(N-(6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indazol-4-y...)
Affinity DataIC50:  12.4nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639815(US20230391786, Example 284)
Affinity DataIC50:  12.4nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639743(2-[4-[6,7-Dichloro-3-(1H-pyrazol-4-yl)indol-1-yl]t...)
Affinity DataIC50:  12.5nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639816(US20230391786, Example 285)
Affinity DataIC50:  12.6nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639674(2-[[6,7-Dichloro-2-(2-hydroxyethyl)-1-oxo-10-(1H-p...)
Affinity DataIC50:  12.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639717(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  12.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639663(N-(6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4-...)
Affinity DataIC50:  13.1nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639817(US20230391786, Example 286)
Affinity DataIC50:  13.1nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639654(6, 7-Dichloro-N-(2,2-difluoroethyl)-3-(1H-pyrazol-...)
Affinity DataIC50:  13.7nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639701(N-(6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl)...)
Affinity DataIC50:  13.8nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM50582657(CHEMBL5082056)
Affinity DataIC50:  14nMAssay Description:Inhibition of human cGASMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM50590390(CHEMBL5174318)
Affinity DataIC50:  14nMAssay Description:Inhibition of human cGASMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639784(1-[6,7-Dichloro-9-(3-hydroxypropylamino)-10-(1H-py...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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