Compile Data Set for Download or QSAR
maximum 50k data
Found 149 of kd data for polymerid = 3907,50007812
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataKd:  0.770nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  1.40nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  1.40nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  1.40nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50542371(CHEMBL4637601)
Affinity DataKd:  3.5nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50542370(CHEMBL4648955)
Affinity DataKd:  13nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50542374(CHEMBL4635162)
Affinity DataKd:  17nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataKd:  17nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataKd:  17nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50542374(CHEMBL4635162)
Affinity DataKd:  17nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50542373(CHEMBL4637411)
Affinity DataKd:  18nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50509569(CHEMBL4456001)
Affinity DataKd:  30nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50509568(CHEMBL4584784)
Affinity DataKd:  32nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50542369(CHEMBL4633633)
Affinity DataKd:  41nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50542372(CHEMBL4646453)
Affinity DataKd:  45nMAssay Description:Inhibition of biotinylated ligand binding to wild-type human partial length CDK8 (M1 to T360 residues) expressed in Escherichia coli BL21 measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50248614(CHEMBL4066819)
Affinity DataKd:  46nMAssay Description:Binding affinity to partial length wild-type human CDK8 (M1 to T360residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072)
Affinity DataKd:  55nMAssay Description:Binding affinity to human CDK8 assessed as dissociation constant by KdELECT Discover assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Affinity DataKd:  95nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Affinity DataKd:  95nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Affinity DataKd:  95nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31099(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S)-3-hydroxy...)
Affinity DataKd:  120nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  120nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  120nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  130nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd:  220nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd:  220nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd:  220nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  310nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  310nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  310nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  310nMAssay Description:Binding affinity to CDK8More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  510nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  510nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705)
Affinity DataKd:  510nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50509570(CHEMBL4447689)
Affinity DataKd:  600nMAssay Description:Binding affinity to CDK8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50459994(CHEMBL4226806 | US11471446, Compound DBA-8)
Affinity DataKd:  830nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50459994(CHEMBL4226806 | US11471446, Compound DBA-8)
Affinity DataKd:  830nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50532781(CHEMBL4571241)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human CDK8More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50532781(CHEMBL4571241)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human CDK8More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Affinity DataKd:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataKd:  1.40E+3nMAssay Description:Displacement of polymer supported probe 25 binding to CDK8 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31340(2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31340(2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31340(2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin...)
Affinity DataKd:  2.30E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM31340(2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM15138(5-indazolyl pyridine 11g | 5-{5-[(2S)-2-amino-3-ph...)
Affinity DataKd:  3.50E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM4851((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Affinity DataKd:  4.50E+3nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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