Affinity DataIC50: 11.9nM Kd: 5.40nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
Affinity DataKd: 5.40nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
Affinity DataKd: 23nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 35nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 46nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 48nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 56nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 67nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 68nMAssay Description:FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 68nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 88nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 88nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 88nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 93nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 95nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Average Binding Constant for FGFR3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 138nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 138nMAssay Description:FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 240nMAssay Description:Average Binding Constant for FGFR3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 280nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Binding affinity to FGFR3More data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 295nMAssay Description:FGFR3: In a final reaction volume of 30 uL, FGFR3 (h) (40 ng/ml) is incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...More data for this Ligand-Target Pair
Ligand Info
Affinity DataKd: 300nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Average Binding Constant for FGFR3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 310nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 310nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 310nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 325nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 325nMAssay Description:FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 360nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 370nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 370nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 370nMAssay Description:Binding constant for FGFR3(G697C) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair