Compile Data Set for Download or QSAR
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Found 286 of kd data for polymerid = 6476,6477
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.180nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.180nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to recombinant human biotinylated and N-terminal DYKDDDDK-tagged TrkB kinase domain (456-822 residues) expressed in sf21 cells asses...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50565310(CHEMBL4792981)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to wild-type human partial length TRKB (Q547 to G838 residues) expressed in mammalian expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  3.40nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705)
Affinity DataKd:  3.80nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  3.80nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  3.80nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  4.10nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50565310(CHEMBL4792981)
Affinity DataKd:  4.90nMAssay Description:Binding affinity to wild-type human partial length TRKC (Q531 to G825 residues) expressed in mammalian expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to human TrkCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50093539(7,8-Dihydroxy-2-phenyl-chromen-4-one | 7,8-Dihydro...)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human TrkB receptor ECD assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  11nMAssay Description:Binding affinity to human TrkBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  14nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  14nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  14nMAssay Description:Binding affinity to TRKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  14nMAssay Description:Binding affinity to TRKCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  17nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  17nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705)
Affinity DataKd:  17nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  18nMAssay Description:Binding affinity to wild type human partial length TRKC (531 to 825 residues) expressed in mammalian expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  18nMAssay Description:Binding affinity to TrkC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  18nMAssay Description:Binding affinity to wild type human partial length TRKC (531 to 825 residues) expressed in mammalian expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKd:  19nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged NTRK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  22nMAssay Description:Binding affinity to TrkB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  22nMAssay Description:Binding affinity to wild type human partial length TRKB (547 to 838 residues) expressed in mammalian expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  22nMAssay Description:Binding affinity to wild type human partial length TRKB (547 to 838 residues) expressed in mammalian expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged NTRK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554329(CHEMBL4646064)
Affinity DataKd:  23nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554331(CHEMBL4798635)
Affinity DataKd:  28nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKd:  32nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  34nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  34nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  34nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM32362(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Affinity DataKd:  36nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM32362(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Affinity DataKd:  36nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM32362(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Affinity DataKd:  36nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  37nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50532781(CHEMBL4571241)
Affinity DataKd:  54nMAssay Description:Binding affinity to human TRKBMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50532781(CHEMBL4571241)
Affinity DataKd:  54nMAssay Description:Binding affinity to human TRKBMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554333(CHEMBL4790500)
Affinity DataKd:  60nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50355499(CHEMBL1908395 | CHEMBL1908842)
Affinity DataKd:  68nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  82nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50554330(CHEMBL4742649)
Affinity DataKd:  112nMAssay Description:Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM32362(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Affinity DataKd:  120nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM50355499(CHEMBL1908395 | CHEMBL1908842)
Affinity DataKd:  120nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM32362(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)
Affinity DataKd:  120nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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