Compile Data Set for Download or QSAR
maximum 50k data
Found 4970 of ki data for polymerid = 2212
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304170(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi:  0nMAssay Description:Antagonist activity at kappa opioid receptor expressed in HEK293 cells assessed as inhibition of compound 16-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM224024(BDBM50241435 | Dynorphin A (1-13) | YGGFLRRXRPKLK)
Affinity DataKi:  0.000800nMAssay Description:Binding affinity towards Wild-type kappa opioid receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50366764(CHEMBL1790045 | MCL-117)
Affinity DataKi:  0.00300nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50378578(CHEMBL1627119)
Affinity DataKi:  0.00500nMAssay Description:Antagonist activity at kappa opioid receptor expressed in HEK293 cells assessed as inhibition of compound 16-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50102711(7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  0.00600nMAssay Description:Antagonist activity on agonist (U50,488) stimulated [35S]GTP-gamma-S, binding in cloned opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  0.0100nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin) assessed as stimulation of [35S]GTPgammaSMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2...)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM199410(US9221831, 75)
Affinity DataKi:  0.0140nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50304175(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-e...)
Affinity DataKi:  0.0150nMAssay Description:Antagonist activity at kappa opioid receptor expressed in HEK293 cells assessed as inhibition of compound 16-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50430590(CHEMBL2338742)
Affinity DataKi:  0.0150nMAssay Description:Displacement of [3H]-diprenorphine from human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50577958(CHEMBL4859512)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50240938(CHEMBL4071862)
Affinity DataKi:  0.0170nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50325534(CHEMBL267495 | nalfurafine)
Affinity DataKi:  0.0190nMAssay Description:Displacement of [3H]DPDPE from human KOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50430589(CHEMBL2338716)
Affinity DataKi:  0.0190nMAssay Description:Displacement of [3H]-diprenorphine from human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.0200nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50430588(CHEMBL2338717)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]-diprenorphine from human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to human cloned kappa opioid receptor expressed in HEK293 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM199350(US9221831, 15)
Affinity DataKi:  0.0200nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50430615(CHEMBL2338718)
Affinity DataKi:  0.0250nMAssay Description:Displacement of [3H]-diprenorphine from human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM86549(CAS_213055 | NSC_213055 | TRK-820)
Affinity DataKi:  0.0250nMMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM364547((4bR,6S,8aS,9R)-N-benzyl-11- (cyclopropylmethyl)-3...)
Affinity DataKi:  0.0260nMAssay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.0270nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50596292(CHEMBL5185211)
Affinity DataKi:  0.0272nMAssay Description:Displacement of [3H]DPDPE from human KOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50303629(17-(Cyclopropylmethyl)-N-(4-methoxyphenyl)morphina...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM83436(2-(3,4-dichlorophenyl)-N-methyl-N-[(5R,7S,8S)-7-(1...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]diprenorphine from human recombinant mu opioid receptor expressed in HEK cells after 60 minsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50013388(6-Ethyl-3-(1-hydroxy-cyclopropylmethyl)-11,11-dime...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM364552(N-((4bR,6S,8aS,9R)-11- (cyclopropylmethyl)- 3-meth...)
Affinity DataKi:  0.0320nMAssay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50174573(CHEMBL3808477)
Affinity DataKi:  0.0330nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50430593(CHEMBL2338739)
Affinity DataKi:  0.0330nMAssay Description:Displacement of [3H]-diprenorphine from human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0340nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50105483((-)-cyclorphan | 17-cyclopropylmethyl-(1R,9R)-17-a...)
Affinity DataKi:  0.0340nMAssay Description:Agonistic activity against kappa opioid receptor in Chinese hamster ovary membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]U-69593 from human kappa opioid receptors expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50596293(CHEMBL5188658)
Affinity DataKi:  0.0356nMAssay Description:Displacement of [3H]DPDPE from human KOR expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.0390nMAssay Description:Compound was evaluated for its binding affinity by displacing [3H]U-69593 to human cloned Kappa opioid receptor transfected into CHO cells using [35S...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50240954(CHEMBL4101576)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM3916(US8530494, 206)
Affinity DataKi:  0.0400nMAssay Description:Binding assay of certain compounds of this invention to the opioid receptor was determine using radioligand binding assay (screening and dose-displac...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50026603(Buprenorphine | CHEBI:3216)
Affinity DataKi:  0.0400nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin) assessed as stimulation of [35S]GTPgammaSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  0.0400nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  0.0400nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50354578(BUPRENORPHINE | US10752592, Compound buprenorphine...)
Affinity DataKi:  0.0400nM ΔG°:  -59.3kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  0.0400nM ΔG°:  -59.3kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  0.0400nM ΔG°:  -59.3kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM199363(US9221831, 28)
Affinity DataKi:  0.0400nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]-diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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