Compile Data Set for Download or QSAR
maximum 50k data
Found 261 of ki data for polymerid = 6149
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102594(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexade...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of matrix metalloprotease-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102608(11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentad...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of matrix metalloprotease-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086884((R)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-9-oxo-1,8-di...)
Affinity DataKi:  3nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078936(CHEMBL87786 | {2-[(2-Amino-1-carbamoyl-ethyl)-(2,4...)
Affinity DataKi:  4nMAssay Description:Inhibition of Matrix metalloprotease-7 MatrilysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50284753((R)-N*1*-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-e...)
Affinity DataKi:  5nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50229322((3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  6nMAssay Description:Binding affinity to MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433877(CHEMBL2380390)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP-7 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433878(CHEMBL2380389)
Affinity DataKi:  12nMAssay Description:Inhibition of MMP-7 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555051(CHEMBL4739996)
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant MMP7 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555050(CHEMBL4764575)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant MMP7 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183711(CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)p...)
Affinity DataKi:  18nMAssay Description:Binding affinity to MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50284755(2-[(Formyl-hydroxy-amino)-methyl]-4-methyl-pentano...)
Affinity DataKi:  18nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183715(CHEMBL207305 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi:  25nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183715(CHEMBL207305 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi:  25nMAssay Description:Binding affinity to MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066659(1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-H...)
Affinity DataKi:  30nMAssay Description:Inhibition of matrix metalloprotease-7 (MMP-7).Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555052(CHEMBL4751015)
Affinity DataKi:  39nMAssay Description:Inhibition of human recombinant MMP7 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433879(CHEMBL2380388)
Affinity DataKi:  50nMAssay Description:Inhibition of MMP-7 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataKi:  54nMAssay Description:Inhibition of matrilysin (Matrix metalloprotease-7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592895(CHEMBL5187653)
Affinity DataKi:  60nMAssay Description:Inhibition of MMP-7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataKi:  75nMAssay Description:Inhibition of recombinant human MMP7 expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate by fluorescence spe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50284751(CHEMBL30804 | [(S)-4-Methyl-2-((S)-9-oxo-1,8-diaza...)
Affinity DataKi:  78nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028945(CHEMBL1738911)
Affinity DataKi:  79nMAssay Description:Inhibition of MMP7 (unknown origin)More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433880(CHEMBL2380387)
Affinity DataKi:  91nMAssay Description:Inhibition of MMP-7 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50284754((S)-2-Mercaptomethyl-4-methyl-pentanoic acid ((S)-...)
Affinity DataKi:  114nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078935((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  117nMAssay Description:Inhibition of Matrix metalloprotease-7 MatrilysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104973(2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmet...)
Affinity DataKi:  177nMAssay Description:Inhibition of matrix metalloprotease-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50393207(CHEMBL2153738)
Affinity DataKi: >200nMAssay Description:Inhibition of MMP-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078949((1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-ca...)
Affinity DataKi:  210nMAssay Description:Inhibition of Matrix metalloprotease-7 MatrilysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433881(CHEMBL2380406)
Affinity DataKi:  230nMAssay Description:Inhibition of MMP-7 (unknown origin) using Mca-PLGLDpa-AR-NH2 as substrate preincubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260828(2,3-bis(4-chlorophenylsulfonamido)-N-hydroxypropan...)
Affinity DataKi:  237nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26526((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...)
Affinity DataKi:  259nMAssay Description:Affinity for Matrix metalloprotease-7 (MMP-7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26526((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...)
Affinity DataKi:  259nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26526((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...)
Affinity DataKi:  259nMAssay Description:Binding affinity to MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260884(2,3-bis(2,4-dimethoxyphenylsulfonamido)-N-hydroxyp...)
Affinity DataKi:  289nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26561((3S,4S)-3-N-hydroxy-4-N-{4-[(2-methyl-1H-indol-3-y...)
Affinity DataKi:  311nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555049(CHEMBL4747528)
Affinity DataKi:  323nMAssay Description:Inhibition of human recombinant MMP7 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50332948((R)-2-(N-((S)-2,3-dihydroxypropyl)-4-methoxyphenyl...)
Affinity DataKi:  344nMAssay Description:Inhibition of MMP7 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078932((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  370nMAssay Description:Inhibition of Matrix metalloprotease-7 MatrilysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM120212(US8691753, 61 | US8691753, 72)
Affinity DataKi:  502nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246792(CHEMBL508335 | N'-{3-(R)-[2-(S)-(1H-Indol-3-yl)-1-...)
Affinity DataKi:  523nMAssay Description:Inhibition of human recombinant pro-MMP7 by spectrofluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260799(CHEMBL497962 | N-hydroxy-2,3-bis(3-(trifluoromethy...)
Affinity DataKi:  602nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078950((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...)
Affinity DataKi:  605nMAssay Description:Inhibition of Matrix metalloprotease-7 MatrilysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260826(CHEMBL497761 | N-hydroxy-2,3-bis(4-methoxyphenylsu...)
Affinity DataKi:  605nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555048(CHEMBL4793938)
Affinity DataKi:  615nMAssay Description:Inhibition of human recombinant MMP7 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50284757((R)-3-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-ethy...)
Affinity DataKi: >620nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260800(2,3-bis(4-fluorophenylsulfonamido)-N-hydroxypropan...)
Affinity DataKi:  625nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM92441(RXP470, 1 | RXP470, Compound 4)
Affinity DataKi:  626nM ΔG°:  -35.4kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592891(CHEMBL5191016)
Affinity DataKi:  626nMAssay Description:Inhibition of human MMP-7 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  626nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216004(4-((2-methylquinolin-4-yl)methoxy)-N-(4-((5-thioxo...)
Affinity DataKi:  635nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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