Compile Data Set for Download or QSAR
maximum 50k data
Found 203 of koff data for polymerid = 50000232,5023,5749,5761,50000232,5023,5749,5761
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataKi:  0.310nM Kon:  0.00000207M-1s-1 Koff:  6.63E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406217(CHEMBL145002)
Affinity DataKi:  0.100nM Kon:  0.00000617M-1s-1 Koff:  6.46E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406216(CHEMBL146003)
Affinity DataKi:  6.31nM Kon:  0.00000871M-1s-1 Koff:  1.32E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataKi:  1.73nM Kon:  0.0000109M-1s-1 Koff:  6.31E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406221(CHEMBL145729)
Affinity DataKi:  1.58nM Kon:  0.0000112M-1s-1 Koff:  7.08E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50288087(2-Ethoxy-5-methyl-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataKi:  0.126nM Kon:  0.0000117M-1s-1 Koff:  1.02E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50029699(2,6-Dichloro-benzoic acid 4-isopropyl-6-methoxy-1,...)
Affinity DataKon:  0.0000120M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50029703(4-Isopropyl-6-methoxy-1,1-dioxo-2-(1-phenyl-1H-tet...)
Affinity DataKon:  0.0000120M-1s-1 Koff:  4.45E+4s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406306(CHEMBL145107)
Affinity DataKi:  100nM Kon:  0.0000138M-1s-1 Koff:  132s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406226(CHEMBL342522)
Affinity DataKi:  5.01nM Kon:  0.0000141M-1s-1 Koff:  2.88E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50288098(2-Ethoxy-5-ethyl-benzo[d][1,3]oxazin-4-one | CHEMB...)
Affinity DataKi:  0.0430nM Kon:  0.0000145M-1s-1 Koff:  3.39E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406208(CHEMBL146004)
Affinity DataKi:  6.31nM Kon:  0.0000151M-1s-1 Koff:  2.57E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286331(4,7-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKon:  0.0000160M-1s-1 Koff:  1.10E+3s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataKi:  1.58nM Kon:  0.0000178M-1s-1 Koff:  1.18E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406206(CHEMBL145152)
Affinity DataKi:  79.4nM Kon:  0.0000178M-1s-1 Koff:  229s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataKon:  0.0000180M-1s-1Assay Description:Rate of deacylation by human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406240(CHEMBL347760)
Affinity DataKi:  0.398nM Kon:  0.0000182M-1s-1 Koff:  4.57E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406244(CHEMBL444082)
Affinity DataKi:  251nM Kon:  0.0000182M-1s-1 Koff:  75.9s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406212(CHEMBL357238)
Affinity DataKi:  1.26E+3nM Kon:  0.0000200M-1s-1 Koff:  15.8s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406303(CHEMBL145690)
Affinity DataKi:  398nM Kon:  0.0000240M-1s-1 Koff:  66.1s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286329(2,6-Dichloro-benzoic acid 4-isopropyl-6-(4-methyl-...)
Affinity DataKon:  0.0000240M-1s-1 Koff:  2.15E+4s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286329(2,6-Dichloro-benzoic acid 4-isopropyl-6-(4-methyl-...)
Affinity DataKon:  0.0000240M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50039631(2,6-Dichloro-benzoic acid 4-isopropyl-1,1,3-trioxo...)
Affinity DataKon:  0.0000270M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286328(2,6-Dichloro-benzoic acid 6-dimethylamino-4-isopro...)
Affinity DataKon:  0.0000270M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50282874(4-Isopropyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-yl...)
Affinity DataKon:  0.0000280M-1s-1 Koff:  9.40E+4s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50282874(4-Isopropyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-yl...)
Affinity DataKon:  0.0000280M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406273(CHEMBL145471)
Affinity DataKi:  15.8nM Kon:  0.0000282M-1s-1 Koff:  1.66E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286327(4,6-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKon:  0.0000290M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286327(4,6-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKon:  0.0000290M-1s-1 Koff:  4.90E+4s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50064322((4-Oxo-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-...)
Affinity DataKi:  17.9nM Kon:  0.0000292M-1s-1 Koff:  1.63E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50064309(2-Isobutoxy-5,6-dimethyl-thieno[2,3-d][1,3]oxazin-...)
Affinity DataKi:  133nM Kon:  0.0000292M-1s-1 Koff:  219s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286326(2,6-Dichloro-benzoic acid 6-fluoro-4-isopropyl-1,1...)
Affinity DataKon:  0.0000300M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406258(CHEMBL145568)
Affinity DataKi:  100nM Kon:  0.0000372M-1s-1 Koff:  363s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406196(CHEMBL335798)
Affinity DataKi:  398nM Kon:  0.0000389M-1s-1 Koff:  97.7s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406290(CHEMBL141707)
Affinity DataKi:  6.31nM Kon:  0.0000436M-1s-1 Koff:  7.59E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286333(5,6-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKon:  0.0000470M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50064317(2-Isobutoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,...)
Affinity DataKi:  51nM Kon:  0.0000515M-1s-1 Koff:  1.01E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406293(CHEMBL356120)
Affinity DataKi:  0.0710nM Kon:  0.0000550M-1s-1 Koff:  7.76E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50282873(4-sec-Butyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-yl...)
Affinity DataKon:  0.0000560M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50282873(4-sec-Butyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-yl...)
Affinity DataKon:  0.0000560M-1s-1 Koff:  9.40E+4s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406285(CHEMBL145583)
Affinity DataKi:  12.6nM Kon:  0.0000562M-1s-1 Koff:  4.68E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50286332(4-Isopropyl-5,6-dimethoxy-1,1-dioxo-2-(1-phenyl-1H...)
Affinity DataKon:  0.0000610M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50064308(2-Diethylamino-5,6,7,8-tetrahydro-benzo[4,5]thieno...)
Affinity DataKi:  16.3nM Kon:  0.0000612M-1s-1 Koff:  3.75E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50064314(5,6-Dimethyl-2-propoxy-thieno[2,3-d][1,3]oxazin-4-...)
Affinity DataKi:  4.02nM Kon:  0.0000628M-1s-1 Koff:  1.56E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50291760(5-Ethyl-2-isopropylamino-benzo[d][1,3]oxazin-4-one...)
Affinity DataKon:  0.0000660M-1s-1Assay Description:Rate of deacylation by human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50406234(CHEMBL145774)
Affinity DataKi:  0.200nM Kon:  0.0000661M-1s-1 Koff:  3.47E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50291760(5-Ethyl-2-isopropylamino-benzo[d][1,3]oxazin-4-one...)
Affinity DataKi:  1nM Kon:  0.0000661M-1s-1 Koff:  7.08E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50064323(2-Benzylsulfanyl-5,6,7,8-tetrahydro-benzo[4,5]thie...)
Affinity DataKi:  290nM Kon:  0.0000692M-1s-1 Koff:  239s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50282868(1,1-Dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmeth...)
Affinity DataKon:  0.0000700M-1s-1 Koff:  1.00E+4s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50282868(1,1-Dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmeth...)
Affinity DataKon:  0.0000700M-1s-1Assay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
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