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Found 1957 Enz. Inhib. hit(s) with Target = '5'-AMP-activated protein kinase'
LigandPNGBDBM563544(US11407768, Compound 1)
Affinity DataEC50:  0.0500nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563546(US11407768, Compound 3)
Affinity DataEC50:  0.0900nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563547(US11407768, Compound 4)
Affinity DataEC50:  0.100nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565695(US11407768, Compound 74)
Affinity DataEC50:  0.150nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565454(US11407768, Compound 53)
Affinity DataEC50:  0.230nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565696(US11407768, Compound 75)
Affinity DataEC50:  0.370nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563553(US11407768, Compound 10)
Affinity DataEC50:  0.400nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563498((2S)-2-amino-3-(4-(2- amino-6-((R)-1-(4- chloro-2-...)
Affinity DataEC50:  0.460nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563556(US11407768, Compound 14)
Affinity DataEC50:  0.5nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM237992(US9394285, 75)
Affinity DataEC50:  0.5nMpH: 7.5 T: 2°CAssay Description:The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Kallyope

US Patent
LigandPNGBDBM543473((((6-chloro-5-(2'-hydroxy-[1,1'-biphenyl]-4- yl)-1...)
Affinity DataEC50:  0.550nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563558(US11407768, Compound 29)
Affinity DataEC50:  0.560nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565456(US11407768, Compound 54)
Affinity DataEC50:  0.570nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563549(US11407768, Compound 6)
Affinity DataEC50:  0.620nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563501((2S)-2-amino-3-(4-(2- amino-6-((R)-2,2,2- trifluor...)
Affinity DataEC50:  0.630nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565561(US11407768, Compound 71)
Affinity DataEC50:  0.630nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563503((2S)-2-amino-3-(4-(2- amino-6-((R)-1-(4- chloro-2-...)
Affinity DataEC50:  0.650nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50195477(CHEMBL3979403)
Affinity DataEC50:  0.700nMAssay Description:Activation of recombinant human His-tagged AMPK alpha2 (2 to 552 residues)/beta1 (2 to 270 residues)/gamma2 (2 to 569 residues) expressed in baculovi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM565449(US11407768, Compound 51)
Affinity DataEC50:  0.720nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563505((S)-2-amino-3-(4-(4- ((R)-1-(4-chloro-2- (5,6-dihy...)
Affinity DataEC50:  0.760nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565498(US11407768, Compound 65)
Affinity DataEC50:  0.770nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565503(US11407768, Compound 66)
Affinity DataEC50:  0.800nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565452(US11407768, Compound 52)
Affinity DataEC50:  0.810nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563563(US11407768, Compound 36)
Affinity DataEC50:  0.840nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563560(US11407768, Compound 31)
Affinity DataEC50:  0.850nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565483(US11407768, Compound 60)
Affinity DataEC50:  0.850nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565483(US11407768, Compound 60)
Affinity DataEC50:  0.850nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563548(US11407768, Compound 5)
Affinity DataEC50:  0.860nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
Astellas Pharma

US Patent
LigandPNGBDBM244234(US9428501, 58)
Affinity DataEC50:  0.860nMT: 2°CAssay Description:In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565476(US11407768, Compound 57)
Affinity DataEC50:  0.890nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565474(US11407768, Compound 56)
Affinity DataEC50:  0.930nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565506(US11407768, Compound 67)
Affinity DataEC50:  0.930nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565478(US11407768, Compound 58)
Affinity DataEC50:  0.930nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563562(US11407768, Compound 33)
Affinity DataEC50:  0.960nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Kallyope

US Patent
LigandPNGBDBM543471((((6-chloro-5-(2'-hydroxy-[1,1'-biphenyl]-4- yl)-1...)
Affinity DataEC50:  0.970nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM213202(US9290517, 133)
Affinity DataEC50:  1nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM213199(US9290517, 129)
Affinity DataEC50:  1nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50195478(CHEMBL3959081)
Affinity DataEC50:  1nMAssay Description:Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using 5'-FAM-SAMS peptide substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM213209(US9290517, 150)
Affinity DataEC50:  1nMpH: 7.3Assay Description:The in vitro AMPK activation assay is performed in a volume of 30 μl in a 384-well plate. Enzyme reactions were assembled in the microtiter plat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50511116(CHEMBL4167177)
Affinity DataEC50:  1nMAssay Description:Activation of recombinant mouse AMPK expressed in Sf9 cells using SAMS peptide as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM565481(US11407768, Compound 59)
Affinity DataEC50:  1.04nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563566(US11407768, Compound 40)
Affinity DataEC50:  1.08nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565494(US11407768, Compound 63)
Affinity DataEC50:  1.09nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Kallyope

US Patent
LigandPNGBDBM543477(2-((6-chloro-5-(2'-hydroxy-4'-(1H-1,2,4- triazol-1...)
Affinity DataEC50:  1.10nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM563568(US11407768, Compound 48)
Affinity DataEC50:  1.16nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Kallyope

US Patent
LigandPNGBDBM192505(US9187477, 1)
Affinity DataEC50:  1.20nMpH: 7.0Assay Description:Activated AMPK complex 1 (containing alphal betalgammal ) was obtained from baculovirus expression system. The gene encoding AMPK alphal was cloned i...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50195538(CHEMBL3898977)
Affinity DataEC50:  1.20nMAssay Description:Activation of full length human recombinant AMPK alpha1/beta1/gamma1 expressed in baculovirus infected sf21 cells using SAMS peptide substrate after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM563550(US11407768, Compound 7)
Affinity DataEC50:  1.22nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM565492(US11407768, Compound 62)
Affinity DataEC50:  1.30nMAssay Description:Compound effect on AMPK enzyme activation was determined in a cell-free format with a 12-point concentration curve. The ADP-Glo detection system was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM237984(US9394285, 67)
Affinity DataEC50:  1.30nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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