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Found 274 Enz. Inhib. hit(s) with Target = 'Cathepsin L'
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  0.0630nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  1.80nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192658(N’-(2-nitrophenylmethylene)benzohydrazide (1i...)
Affinity DataKi:  4.20nM ΔG°:  -49.7kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192660(N’-(4-nitrophenylmethylene)benzohydrazide (1k...)
Affinity DataKi:  5.53nM ΔG°:  -49.0kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192659(N’-(3-nitrophenylmethylene)benzohydrazide (1j...)
Affinity DataKi:  5.86nM ΔG°:  -48.9kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192654(N’-(4-chlorophenylmethylene)benzohydrazide (1...)
Affinity DataKi:  6.34nM ΔG°:  -48.7kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192652(N’-(2-chlorophenylmethylene)benzohydrazide (1...)
Affinity DataKi:  7.30nM ΔG°:  -48.3kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192655(N’-(2-methoxyphenylmethylene)benzohydrazide (...)
Affinity DataKi:  8.14nM ΔG°:  -48.0kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192653(N’-(3-chlorophenylmethylene)benzohydrazide (1...)
Affinity DataKi:  8.63nM ΔG°:  -47.9kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192650(N’-(phenylmethylene)benzohydrazide (1a))
Affinity DataKi:  13nM ΔG°:  -46.8kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93184(Cathepsin Inhibitor, Column 6 Row 2)
Affinity DataKi:  18nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192657(N’-(4-methoxyphenylmethylene)benzohydrazide (...)
Affinity DataKi:  19.8nM ΔG°:  -45.7kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192656(N’-(3-methoxyphenylmethylene)benzohydrazide (...)
Affinity DataKi:  28.6nM ΔG°:  -44.8kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93178(Cathepsin Inhibitor, Column 4 Row 2)
Affinity DataKi:  36nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192668(2-phenyl-5-(4-nitrophenyl)-1,3,4-oxadiazole (2k))
Affinity DataKi:  47.3nM ΔG°:  -43.5kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93175(Cathepsin Inhibitor, Column 3 Row 2)
Affinity DataKi:  53nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192667(2-phenyl-5-(2-nitrophenyl)-1,3,4-oxadiazole (2i))
Affinity DataKi:  57nM ΔG°:  -43.0kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM63525(2-(3-nitrophenyl)-5-phenyl-1,3,4-oxadiazole | 2-ph...)
Affinity DataKi:  63.4nM ΔG°:  -42.7kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM48184(2-(3-chlorophenyl)-5-phenyl-1,3,4-oxadiazole | 2-p...)
Affinity DataKi:  70.2nM ΔG°:  -42.5kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93183(Cathepsin Inhibitor, Column 6 Row 1)
Affinity DataKi:  90nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192662(2-phenyl-5-(2-chlorophenyl)-1,3,4-oxadiazole (2c))
Affinity DataKi:  92.1nM ΔG°:  -41.8kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192651(N’-(4-methylphenylmethylene)benzohydrazide (1...)
Affinity DataKi:  95.9nM ΔG°:  -41.7kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192663(2-phenyl-5-(4-chlorophenyl)-1,3,4-oxadiazole (2e))
Affinity DataKi:  99.3nM ΔG°:  -41.6kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM103351(US8552202, Compound 3)
Affinity DataKi:  100nMAssay Description:In vitro inhibition assay using cathepsin.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93181(Cathepsin Inhibitor, Column 5 Row 2)
Affinity DataKi:  110nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93172(Cathepsin Inhibitor, Column 2 Row 2)
Affinity DataKi:  120nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192661(2,5-diphenyl-1,3,4-oxadiazole (2a))
Affinity DataKi:  124nM ΔG°:  -41.0kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93177(Cathepsin Inhibitor, Column 4 Row 1)
Affinity DataKi:  130nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93180(Cathepsin Inhibitor, Column 5 Row 1)
Affinity DataKi:  130nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192665(2-phenyl-5-(3-methoxyphenyl)-1,3,4-oxadiazole (2g))
Affinity DataKi:  144nM ΔG°:  -40.6kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93174(Cathepsin Inhibitor, Column 3 Row 1)
Affinity DataKi:  150nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM103364(US8552202, Compound 13)
Affinity DataKi:  170nMAssay Description:In vitro inhibition assay using cathepsin.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM50336482(CHEMBL1668599 | citibrasine)
Affinity DataKi:  200nMAssay Description:Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plotsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192664(2-phenyl-5-(2-methoxyphenyl)-1,3,4-oxadiazole (2f))
Affinity DataKi:  216nM ΔG°:  -39.6kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93171(Cathepsin Inhibitor, Column 2 Row 1)
Affinity DataKi:  230nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM103358(US8552202, Compound 9)
Affinity DataKi:  240nMAssay Description:In vitro inhibition assay using cathepsin.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin L(Capra hircus (Goat))
Kurukshetra University

LigandPNGBDBM192666(2-phenyl-5-(4-methoxyphenyl)-1,3,4-oxadiazole (2h))
Affinity DataKi:  337nM ΔG°:  -38.4kJ/molepH: 5.0 T: 2°CAssay Description:The proteolytic activity was estimated at pH 5.0, 37 °C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM50385972(CHEMBL2042470)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM50336477(1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-met...)
Affinity DataKi:  500nMAssay Description:Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plotsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM103350(US8552202, Compound 2)
Affinity DataKi:  700nMAssay Description:In vitro inhibition assay using cathepsin.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM50385984(CHEMBL2042454)
Affinity DataKi:  800nMAssay Description:Uncompetitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Gsk

LigandPNGBDBM50385977(CHEMBL2042446)
Affinity DataKi:  800nMAssay Description:Noncompetitive inhibition of human recombinant cathepsin V expressed in Pichia pastoris using Z-Phe-Arg-MCA as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93185(Cathepsin Inhibitor, Column 6 Row 3)
Affinity DataKi: >1.00E+3nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93182(Cathepsin Inhibitor, Column 5 Row 3)
Affinity DataKi: >1.00E+3nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93179(Cathepsin Inhibitor, Column 4 Row 3)
Affinity DataKi: >1.00E+3nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93176(Cathepsin Inhibitor, Column 3 Row 3)
Affinity DataKi: >1.00E+3nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93173(Cathepsin Inhibitor, Column 2 Row 3)
Affinity DataKi: >1.00E+3nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93170(Cathepsin Inhibitor, Column 1 Row 3)
Affinity DataKi: >1.00E+3nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93169(Cathepsin Inhibitor, Column 1 Row 2)
Affinity DataKi: >1.00E+3nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM93168(Cathepsin Inhibitor, Column 1 Row 1)
Affinity DataKi: >1.00E+3nMpH: 5.5Assay Description:Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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