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Found 7 Enz. Inhib. hit(s) with Target = 'Dickkopf-related protein 1'
TargetDickkopf-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303037((1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-...)
Affinity DataEC50:  630nMAssay Description:Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDickkopf-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303038(1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-a...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDickkopf-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303039(4-(4-(naphthalen-2-yl)pyrimidin-2-ylamino)benzenes...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDickkopf-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303036(CHEMBL569986 | N-((1-(4-(naphthalen-2-yl)pyrimidin...)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDickkopf-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303035(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataEC50:  7.80E+3nMAssay Description:Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDickkopf-related protein 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303040(4-(methyl(4-(5-methylthiophen-2-yl)pyrimidin-2-yl)...)
Affinity DataEC50:  9.80E+3nMAssay Description:Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDickkopf-related protein 1(Mus musculus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50135174(CHEMBL3747431)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mouse DKK1 assessed as inhibition of DKK1-alkaline phophatase binding to LRP5 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed