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Found 721 Enz. Inhib. hit(s) with Target = 'Extracellular calcium-sensing receptor'
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444165(CHEMBL3093422)
Affinity DataEC50:  2nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444166(CHEMBL3093421)
Affinity DataEC50:  3nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM205500(US9253997, 6)
Affinity DataEC50:  3nMpH: 7.2 T: 2°CAssay Description:293E cells (EBNA1-expressing IIEK293 cells, ATCC No. CRL-10852) were cultured in DMEM (1.0 g/ml Glucose-containing Dulbecco's modified Eagle medium, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM205515(US9253997, 67)
Affinity DataEC50:  3nMpH: 7.2 T: 2°CAssay Description:293E cells (EBNA1-expressing IIEK293 cells, ATCC No. CRL-10852) were cultured in DMEM (1.0 g/ml Glucose-containing Dulbecco's modified Eagle medium, ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444163(CHEMBL3093424)
Affinity DataEC50:  3nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM205502(US9253997, 14)
Affinity DataEC50:  3nMpH: 7.2 T: 2°CAssay Description:293E cells (EBNA1-expressing IIEK293 cells, ATCC No. CRL-10852) were cultured in DMEM (1.0 g/ml Glucose-containing Dulbecco's modified Eagle medium, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444173(CHEMBL3093425)
Affinity DataEC50:  4nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM205511(US9253997, 47)
Affinity DataEC50:  4nMpH: 7.2 T: 2°CAssay Description:293E cells (EBNA1-expressing IIEK293 cells, ATCC No. CRL-10852) were cultured in DMEM (1.0 g/ml Glucose-containing Dulbecco's modified Eagle medium, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261674(CHEMBL4086045)
Affinity DataEC50:  5nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444164(CHEMBL3093423)
Affinity DataEC50:  6nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261667(CHEMBL4101097)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human beta-2 adrenergic receptor expressed in human H292 cells assessed as accumulation of intracellular cAMP after 1 hr by Alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261669(CHEMBL4084641)
Affinity DataEC50:  7.90nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444170(CHEMBL3093428)
Affinity DataEC50:  9nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444169(CHEMBL3093429)
Affinity DataEC50:  9nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50416874(CHEMBL1256368)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulation of calcium sensing receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444171(CHEMBL3093427)
Affinity DataEC50:  10nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261664(CHEMBL4067601)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human beta-2 adrenergic receptor expressed in human H292 cells assessed as accumulation of intracellular cAMP after 1 hr by Alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261675(CHEMBL4060025)
Affinity DataEC50:  13nMAssay Description:Displacement of [3H]CP55940 from human brain CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261666(CHEMBL4100132)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human beta-2 adrenergic receptor expressed in human H292 cells assessed as accumulation of intracellular cAMP after 1 hr by Alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444167(CHEMBL3093411)
Affinity DataEC50:  16nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325740((R)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Affinity DataEC50:  17nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50272596(CHEMBL4126450)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human CaSR expressed in CHO cells assessed as increase in intracellular calcium mobilization after 1 hr by Fura-2 dye-based fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444177(CHEMBL3093419)
Affinity DataEC50:  17nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM205517(US9253997, 77)
Affinity DataEC50:  18nMpH: 7.2 T: 2°CAssay Description:293E cells (EBNA1-expressing IIEK293 cells, ATCC No. CRL-10852) were cultured in DMEM (1.0 g/ml Glucose-containing Dulbecco's modified Eagle medium, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444175(CHEMBL3093420)
Affinity DataEC50:  18nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444172(CHEMBL3093426)
Affinity DataEC50:  19nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50416875(AMG-073 | AMG073 HCL | CINACALCET | CINACALCET HYD...)
Affinity DataEC50:  19.9nMAssay Description:Positive allosteric modulation of calcium sensing receptor by cell based assayMore data for this Ligand-Target Pair
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432950(CHEMBL2377735)
Affinity DataEC50:  20nMAssay Description:Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261693(CHEMBL4072950)
Affinity DataEC50:  20nMAssay Description:Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432976(CHEMBL2377740)
Affinity DataEC50:  20nMAssay Description:Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444168(CHEMBL3093430)
Affinity DataEC50:  20nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50140173(CHEMBL3753306)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50140173(CHEMBL3753306)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325734((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Affinity DataEC50:  23nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444180(CHEMBL3093416)
Affinity DataEC50:  23nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299683(1(R)-1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-y...)
Affinity DataEC50:  23nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50416874(CHEMBL1256368)
Affinity DataEC50:  25.1nMAssay Description:Positive allosteric modulation of calcium sensing receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325735((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Affinity DataEC50:  27nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432975(CHEMBL2377741)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432973(CHEMBL2377743)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432967(CHEMBL2377749)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50432968(CHEMBL2377748)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50416876(CHEMBL1256403)
Affinity DataEC50:  31.6nMAssay Description:Positive allosteric modulation of calcium sensing receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261665(CHEMBL4082125)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human beta-2 adrenergic receptor expressed in human H292 cells assessed as accumulation of intracellular cAMP after 1 hr by Alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50444181(CHEMBL3093417)
Affinity DataEC50:  36nMAssay Description:Activation of human CaSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325736((R)-1-(3-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Affinity DataEC50:  37nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM205508(US9253997, 41)
Affinity DataEC50:  39nMpH: 7.2 T: 2°CAssay Description:293E cells (EBNA1-expressing IIEK293 cells, ATCC No. CRL-10852) were cultured in DMEM (1.0 g/ml Glucose-containing Dulbecco's modified Eagle medium, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261691(CHEMBL4094738)
Affinity DataEC50:  40nMAssay Description:Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261695(CHEMBL4092377)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261696(CHEMBL4074358)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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