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Found 261 Enz. Inhib. hit(s) with Target = 'Macrophage-stimulating protein receptor'
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataEC50:  900nMAssay Description:Inhibition of Ron by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Affinity DataEC50: >2.00E+3nMAssay Description:Inhibition of Ron by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  1nMAssay Description:Inhibition of RON by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  1nMAssay Description:Inhibition of RON by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of RON (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of RON (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataKi:  8.99E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50:  200nMAssay Description:Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50437157(CHEMBL2401814)
Affinity DataIC50:  130nMAssay Description:Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50:  25nMAssay Description:Inhibition of RON (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50:  4.24nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  3.52nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM139539(US8889696, 39)
Affinity DataIC50: >1.00E+4nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)
Affinity DataIC50:  1.79E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage-stimulating protein receptor [983-1400,G1195S](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM213708(US9283225, A1)
Affinity DataIC50:  4.30nMpH: 7.5 T: 2°CAssay Description:The kinase assay was carried out as 384-well FlashPlate assay. As test plates 384-well streptavidine coated FlashPlate microtitre plates from Perkin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage-stimulating protein receptor [983-1400,G1195S](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM213709(US9283225, A3)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:The kinase assay was carried out as 384-well FlashPlate assay. As test plates 384-well streptavidine coated FlashPlate microtitre plates from Perkin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM251929(US9481668, A6)
Affinity DataIC50:  30nMpH: 7.5 T: 2°CAssay Description:The kinase assay was carried out as 384-well FlashPlate assay. As test plates 384-well streptavidine coated FlashPlate microtitre plates from Perkin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317326(CHEMBL1086932 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  150nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317323(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  50nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317325(4-(2-fluoro-4-(1-phenyl-5-(trifluoromethyl)-1H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317324(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50:  80nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50247962(CHEMBL462232 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)
Affinity DataIC50:  170nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306503(4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317334(CHEMBL1095036 | N-(3-fluoro-4-(2-(4-((2-(methylsul...)
Affinity DataIC50:  80nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317327(CHEMBL1086675 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  210nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317335(CHEMBL1095356 | N-(4-(2-(4-(dimethylcarbamoyl)phen...)
Affinity DataIC50:  30nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317336(CHEMBL1095357 | N-(4-(2-(4-((2-(dimethylamino)ethy...)
Affinity DataIC50:  90nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317337((S)-N-(4-(2-(4-(3-(dimethylamino)pyrrolidine-1-car...)
Affinity DataIC50:  100nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306507(4,4,4-trifluoro-N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  410nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317338(6-(7-(2-fluoro-4-(1-phenyl-5-(trifluoromethyl)-1H-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317339(6-(7-(2-fluoro-4-(1-phenyl-5-(trifluoromethyl)-1H-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317340(CHEMBL1095361 | N-(4-(2-(1-acetyl-1,2,3,6-tetrahyd...)
Affinity DataIC50:  90nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317333((S)-N-(3-fluoro-4-(2-(4-((N-(1-methoxypropan-2-yl)...)
Affinity DataIC50:  60nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317332(CHEMBL1095034 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  60nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317328(CHEMBL1086676 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  590nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317330(CHEMBL1098157 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317331(1-tert-butyl-N-(3-fluoro-4-(2-(1-methyl-1H-imidazo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50317329(5-amino-N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-y...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50007744(CHEMBL3233767)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant RON (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant RON (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibition of Tel-fused RON kinase-mediated mouse BaF3 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306683((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of recombinant RON by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant RON by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant RON by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  8.20E+3nMAssay Description:Binding affinity to MST1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13535(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to MST1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to MST1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to MST1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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