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Found 1144 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 9'
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  10nMAssay Description:Inhibition of JNK2 in OVA-challenged and IgE-sensitized cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  4nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15956(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Affinity DataKi:  4nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  4nMAssay Description:Inhibition of human JNK2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50314147(CHEMBL1094014 | trans-4-(4-(1-benzyl-5-(dimethylam...)
Affinity DataKi:  6nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  6.20nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15939(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Affinity DataKi:  9nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15976(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Affinity DataKi:  13nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50314148(CHEMBL1089007 | trans-4-(4-(3-(tetrahydro-2H-pyran...)
Affinity DataKi:  17nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  70nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50402020(CHEMBL2205426)
Affinity DataKi:  262nMAssay Description:Inhibition of recombinant JNK2A2 after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15907(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Affinity DataKi:  440nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15968(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Affinity DataKi:  1.90E+3nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50314073(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)
Affinity DataKi: >4.00E+5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15868(6-chloro-9-hydroxy-1,3-dimethyl-1H,4H,9H-pyrazolo[...)
Affinity DataIC50:  3.10E+3nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15869(6-chloro-9-hydroxy-1-methyl-3-(trifluoromethyl)-1H...)
Affinity DataIC50:  3.00E+3nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15909(2-pyridinecarboxamide deriv. 3 | 4-Amino-5-cyano-6...)
Affinity DataIC50:  120nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15911(2-pyridinecarboxamide deriv. 8a | 4-Amino-5-cyano-...)
Affinity DataIC50:  610nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15912(2-pyridinecarboxamide deriv. 8b | 4-Amino-5-cyano-...)
Affinity DataIC50:  190nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15913(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Affinity DataIC50:  120nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15914(2-pyridinecarboxamide deriv. 8d | 4-Amino-5-cyano-...)
Affinity DataIC50:  53nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15915(2-pyridinecarboxamide deriv. 8e | 4-Amino-5-cyano-...)
Affinity DataIC50:  41nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15916(2-pyridinecarboxamide deriv. 8f | 4-(5-{[(4-Amino-...)
Affinity DataIC50:  11nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15917(2-pyridinecarboxamide deriv. 8g | 4-amino-5-cyano-...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15918(2-pyridinecarboxamide deriv. 12 | 4-Amino-5-chloro...)
Affinity DataIC50:  74nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15919(2-pyridinecarboxamide deriv. 13 | 4-Amino-5-chloro...)
Affinity DataIC50:  68nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15920(2-pyridinecarboxamide deriv. 15 | 4-Amino-6-chloro...)
Affinity DataIC50:  4.40E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15907(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Affinity DataIC50:  1.10E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15923(Aminopyridine-Based Inhibitor 6b | N-(4-amino-5-cy...)
Affinity DataIC50:  690nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15924(Aminopyridine-Based Inhibitor 6c | N-(4-Amino-5-cy...)
Affinity DataIC50:  8.40E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15925(Aminopyridine-Based Inhibitor 6d | N-(4-Amino-5-cy...)
Affinity DataIC50:  3.50E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15926(Aminopyridine-Based Inhibitor 6e | N-(4-Amino-5-cy...)
Affinity DataIC50:  770nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15927(Aminopyridine-Based Inhibitor 6f | N-(4-Amino-5-cy...)
Affinity DataIC50:  4.90E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15928(Aminopyridine-Based Inhibitor 6g | N-(4-Amino-5-cy...)
Affinity DataIC50:  900nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15929(Aminopyridine-Based Inhibitor 6h | N-(4-Amino-5-cy...)
Affinity DataIC50:  610nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15930(Aminopyridine-Based Inhibitor 6i | N-(4-Amino-5-cy...)
Affinity DataIC50:  740nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15931(Aminopyridine-Based Inhibitor 6j | N-(4-Amino-5-cy...)
Affinity DataIC50:  790nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15932(Aminopyridine-Based Inhibitor 6k | N-(4-Amino-5-cy...)
Affinity DataIC50:  360nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15933(Aminopyridine-Based Inhibitor 6l | N-(4-Amino-5-cy...)
Affinity DataIC50:  260nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15934(Aminopyridine-Based Inhibitor 6m | N-(4-Amino-5-cy...)
Affinity DataIC50:  310nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15935(Aminopyridine-Based Inhibitor 6n | N-(4-Amino-5-cy...)
Affinity DataIC50:  274nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataIC50:  160nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15936(Aminopyridine-Based Inhibitor 6p | N-(4-Amino-5-cy...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15937(Aminopyridine-Based Inhibitor 6q | N-(4-Amino-5-cy...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15938(2-(4-Acetylamino-2,5-dimethoxyphenyl)-N-(4-amino-5...)
Affinity DataIC50:  26nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15939(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Affinity DataIC50:  150nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15940(Aminopyridine-Based Inhibitor 6t | N-(4-Amino-5-cy...)
Affinity DataIC50:  160nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15941(Aminopyridine-Based Inhibitor 6u | N-(4-Amino-5-cy...)
Affinity DataIC50:  100nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15942((4-Amino-5-cyano-6-ethoxypyridin-2-yl)carbamic Aci...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15943(1-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-3-ethylur...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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