Affinity DataEC50: 0.100nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptorMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 0.700nMAssay Description:Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)More data for this Ligand-Target Pair
Affinity DataEC50: 0.880nMAssay Description:Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 14(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 0.920nMAssay Description:Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)More data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphateMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at human P2Y12 receptorMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 1.30nMAssay Description:The compound was evaluated for antagonist activity against platelet P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Effective concentration required for the activation of human S317A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inos...More data for this Ligand-Target Pair
Affinity DataEC50: 1.89nMAssay Description:Agonist activity at human P2Y1 receptor expressed in human 1321N1 cells by PLC assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.More data for this Ligand-Target Pair
TargetP2Y purinoceptor 14(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 1.92nMAssay Description:Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of...More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)More data for this Ligand-Target Pair
Affinity DataEC50: 2.20nMAssay Description:Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate i...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at turkey P2Y1R expressed in 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(T221A) human P2Y1 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Effective concentration required for the activation of human K196A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inos...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at turkey P2Y1 receptor expressed in human 132N1 receptor assessed as induction of intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at G-protein coupled P2Y1 receptor expressed in human 1321N1 cells assessed as increase in calcium by Fura2 assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Effective concentration required for the activation of human R301A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inos...More data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)More data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Agonist activity at P2Y1 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Agonist activity at rat P2Y1R expressed in HEK293 cells assessed as release of intracellular calcium by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Effective concentration to activate wild-type P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphateMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Effective concentration required for the activation of human E209D mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inos...More data for this Ligand-Target Pair
Affinity DataEC50: 3.60nMAssay Description:Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)More data for this Ligand-Target Pair
Affinity DataEC50: 3.60nMAssay Description:Effective concentration required for the activation of human D208A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inos...More data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
Affinity DataEC50: 3.90nMAssay Description:Effective concentration required for the activation of human D289A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inos...More data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at turkey P2Y purinoceptor 1 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrof...More data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitati...More data for this Ligand-Target Pair
Affinity DataEC50: 4.40nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)More data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Agonist activity at rat brain P2Y1R transfected in HEK293 cells assessed as induction of intracellular calcium mobilization by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.70nMAssay Description:Effective concentration required for the activation of human R195A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inos...More data for this Ligand-Target Pair
Affinity DataEC50: 4.80nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair