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Found 1329 Enz. Inhib. hit(s) with Target = 'Proteinase-activated receptor 1'
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031386((S)-2-{(S)-2-[(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  10nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031422((S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  30nMAssay Description:Evaluated for the activity of Radio-ligand Peptides upon the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50054858(CHEMBL144504 | Thiophene-2-carboxylic acid [1-[1-[...)
Affinity DataEC50:  100nMAssay Description:Concentration of compound required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031382((S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  120nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031432((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3...)
Affinity DataEC50:  130nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031427((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(4-flu...)
Affinity DataEC50:  140nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031380((S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  150nMAssay Description:Evaluated for the activity of Radio-ligand Peptides upon the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031406((S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  160nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031406((S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  160nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50440859(CHEMBL2431718)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human PAR1 expressed in African green monkey COS7 cells assessed as stimulation of inositol triphosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031413((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(4-flu...)
Affinity DataEC50:  200nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031392((S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-h...)
Affinity DataEC50:  200nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031398((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(3,4-d...)
Affinity DataEC50:  270nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50054859(2-{(R)-2-[2-(3-Acetylamino-propionylamino)-3-(4-fl...)
Affinity DataEC50:  270nMAssay Description:Effective concentration for stimulation of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031392((S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-h...)
Affinity DataEC50:  280nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031398((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(3,4-d...)
Affinity DataEC50:  300nMAssay Description:Evaluated for the activity of Radio-ligand Peptides upon the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031424((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-phenyl...)
Affinity DataEC50:  400nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077726(5-Bromo-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Affinity DataEC50:  460nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031397((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(3,4-d...)
Affinity DataEC50:  500nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031414(1-{(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-...)
Affinity DataEC50:  500nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077747(4-Oxo-4H-chromene-2-carboxylic acid {(S)-1-[(S)-1-...)
Affinity DataEC50:  510nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031407((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-(4-chl...)
Affinity DataEC50:  700nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50454438(CHEMBL2370948)
Affinity DataEC50:  720nMAssay Description:Effective concentration for stimulation of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077752(5-((E)-2-Methyl-3-phenyl-acryloylamino)-1H-[1,2,4]...)
Affinity DataEC50:  760nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077748(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Affinity DataEC50:  760nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031417((S)-2-[(S)-2-((S)-2-Amino-propionylamino)-3-phenyl...)
Affinity DataEC50:  800nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077744(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077743(CHEMBL33532 | Quinoxaline-2-carboxylic acid {(S)-1...)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077738(5-((E)-3-Naphthalen-1-yl-acryloylamino)-1H-[1,2,4]...)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031381((S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino...)
Affinity DataEC50:  1.00E+3nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077741(5-[(E)-3-(2-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Affinity DataEC50:  1.10E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077728(Biphenylene-2-carboxylic acid {(S)-1-[(S)-1-((S)-1...)
Affinity DataEC50:  1.20E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077750(6-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Affinity DataEC50:  1.20E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031401((S)-2-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propio...)
Affinity DataEC50:  1.20E+3nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077732(CHEMBL285018 | [1,2,3]Thiadiazole-4-carboxylic aci...)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031405((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propion...)
Affinity DataEC50:  1.30E+3nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031386((S)-2-{(S)-2-[(S)-2-[(S)-2-((S)-2-Amino-propionyla...)
Affinity DataEC50:  1.50E+3nMAssay Description:Evaluated for the activity of Radio-ligand Peptides upon the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077749(5-((Z)-2-Fluoro-3-phenyl-acryloylamino)-1H-[1,2,4]...)
Affinity DataEC50:  1.70E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50054870(1H-Indole-2-carboxylic acid [1-[1-[1-(1-carbamoyl-...)
Affinity DataEC50:  1.80E+3nMAssay Description:Effective concentration for stimulation of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077751(5-[(E)-3-(2-Nitro-phenyl)-acryloylamino]-1H-[1,2,4...)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077740(5-[(E)-3-(3-Nitro-phenyl)-acryloylamino]-1H-[1,2,4...)
Affinity DataEC50:  1.90E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077730(CHEMBL284498 | N-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031420(CHEMBL263369 | SFLLRDPQDK-NH2)
Affinity DataEC50:  2.00E+3nMAssay Description:Evaluated for the activation of human thrombin receptor measured by platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077746(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Affinity DataEC50:  2.10E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077759(5-[(E)-3-(3-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Affinity DataEC50:  2.40E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077754((S)-2-[(S)-3-Cyclohexyl-2-((E)-3-pyridin-3-yl-acry...)
Affinity DataEC50:  2.60E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077763(5-((E)-3-Thiophen-2-yl-acryloylamino)-1H-[1,2,4]tr...)
Affinity DataEC50:  2.90E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077764(3-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Affinity DataEC50:  2.90E+3nMAssay Description:Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031414(1-{(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-...)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of PAR-1 in human platelet-rich plasma assessed as induction of platelet aggregation by turbidimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077720(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid ((S)-...)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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