Found 2783 Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase'
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.00210nMAssay Description:Inhibition against Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.390nMAssay Description:Inhibition of Plasmodium falciparum DHFRMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.460nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Mahidol University
Mahidol University
Affinity DataKi: 0.0110nM ΔG°: -62.5kJ/mole IC50: 0.570nMpH: 7.0 T: 2°CAssay Description:The concentration of inhibitor that inhibited 50% of the parasite growth (IC50) was determined from the sigmoidal curve obtained by plotting the perc...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.570nMAssay Description:Inhibition of Plasmodium falciparum DHFRMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.580nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.580nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.840nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Concentration inhibiting T. gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Toxoplasma gondii(tg)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (tg)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibitory concentration against Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.880nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondiiMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University Of Connecticut At Storrs
University Of Connecticut At Storrs
Affinity DataIC50: 1.10nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University Of Connecticut At Storrs
University Of Connecticut At Storrs
Affinity DataIC50: 1.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 microM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.40nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Plasmodium falciparum DHFRMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University Of Connecticut At Storrs
University Of Connecticut At Storrs
Affinity DataIC50: 1.80nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University Of Connecticut At Storrs
University Of Connecticut At Storrs
Affinity DataIC50: 1.80nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii was evaluated using 90 microM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University Of Connecticut At Storrs
University Of Connecticut At Storrs
Affinity DataIC50: 2.10nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University Of Connecticut At Storrs
University Of Connecticut At Storrs
Affinity DataIC50: 2.10nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University Of Connecticut At Storrs
University Of Connecticut At Storrs
Affinity DataIC50: 2.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium hominis)
University Of Connecticut At Storrs
University Of Connecticut At Storrs
Affinity DataIC50: 2.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondiiMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
East China University Of Science And Technology
Curated by ChEMBL
East China University Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 0.0200nM ΔG°: -61.1kJ/mole IC50: 2.30nMpH: 7.0 T: 2°CAssay Description:The concentration of inhibitor that inhibited 50% of the parasite growth (IC50) was determined from the sigmoidal curve obtained by plotting the perc...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals
US Patent
Vyera Pharmaceuticals
US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair