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Found 54 Enz. Inhib. hit(s) with Target = 'Cystine/glutamate transporter'
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126160(CHEMBL3629669)
Affinity DataIC50:  4nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126159(CHEMBL3629668)
Affinity DataIC50:  10nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126156(CHEMBL3629579)
Affinity DataIC50:  10nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126155(CHEMBL3629578)
Affinity DataIC50:  20nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126162(CHEMBL3629671)
Affinity DataIC50:  30nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126153(CHEMBL3629576)
Affinity DataIC50:  30nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126154(CHEMBL3629577)
Affinity DataIC50:  40nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126152(CHEMBL3629575)
Affinity DataIC50:  60nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126161(CHEMBL3629670)
Affinity DataIC50:  100nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  140nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human Calu1 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ fr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Affinity DataIC50:  160nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  200nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  200nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126157(CHEMBL3629580)
Affinity DataIC50:  300nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126151(CHEMBL3629574)
Affinity DataIC50:  800nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM17660((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of amino acid transport system xc-More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50053588((S)-4-(amino(carboxy)methyl)benzoic acid | (S)-4-c...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of amino acid transport system xc-More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50053588((S)-4-(amino(carboxy)methyl)benzoic acid | (S)-4-c...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM17663((2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | ...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of amino acid transport system xc-More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355004(CHEMBL1834956)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50097125(2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355002(CHEMBL1834954)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50220147((S)-2-amino-4-sulfobutanoic acid | CHEMBL230951 | ...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of amino acid transport system xc-More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355009(CHEMBL1614646)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355002(CHEMBL1834954)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355004(CHEMBL1834956)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355007(CHEMBL1834959)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50109609((2R)-2-amino-3-mercaptopropanoic acid | (2R)-2-ami...)
Affinity DataIC50:  1.16E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378666(CHEMBL601837)
Affinity DataIC50:  1.27E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378667(CHEMBL604574)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355011(CHEMBL1834962)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355010(CHEMBL1834961)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378668(CHEMBL606915)
Affinity DataIC50:  2.25E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355012(CHEMBL1834963)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378665(CHEMBL590556)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Affinity DataIC50:  4.50E+5nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Affinity DataIC50:  4.60E+5nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human Calu1 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ fr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355006(CHEMBL1834958)
Affinity DataIC50:  7.00E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355006(CHEMBL1834958)
Affinity DataIC50:  7.00E+5nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355003(CHEMBL1834955)
Affinity DataIC50:  9.00E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355008(CHEMBL1834960)
Affinity DataIC50:  9.20E+5nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355008(CHEMBL1834960)
Affinity DataIC50:  9.20E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM60918(5-Amino-2-hydroxy-benzoic acid | MESALAMINE | MLS0...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM39340(4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sul...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM82251((R)-4-Carboxyphenylglycine | (S)-4CPG | CAS_134052...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355001(CHEMBL1834953)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355005(CHEMBL1834957)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378670(CHEMBL600474)
Affinity DataKi:  5.20E+4nMAssay Description:Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50109609((2R)-2-amino-3-mercaptopropanoic acid | (2R)-2-ami...)
Affinity DataKi:  5.90E+4nMAssay Description:Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378666(CHEMBL601837)
Affinity DataKi:  6.00E+4nMAssay Description:Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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