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Found 655 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 7'
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305863(3-(3-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305859(5-methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305864(3-(2-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50196289(6-(4-methoxyphenyl)-5-methyl-3-phenylisoxazolo[4,5...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305877(6-(4-methoxyphenyl)-5-methyl-3-(pyridin-4-yl)isoxa...)
Affinity DataIC50:  26nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50196291(6-(benzo[d][1,3]dioxol-5-yl)-5-methyl-3-phenylisox...)
Affinity DataIC50:  26nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305862(3-(4-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305873(6-(3-(dimethylamino)phenyl)-5-methyl-3-phenylisoxa...)
Affinity DataIC50:  31nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305868(5-methyl-3-phenyl-6-p-tolylisoxazolo[4,5-c]pyridin...)
Affinity DataIC50:  51nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305869(6-(4-fluorophenyl)-5-methyl-3-phenylisoxazolo[4,5-...)
Affinity DataIC50:  72nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305874(5-methyl-3-phenyl-6-(3-(trifluoromethyl)phenyl)iso...)
Affinity DataIC50:  96nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305865(5-methyl-6-phenyl-3-(pyridin-4-yl)isoxazolo[4,5-c]...)
Affinity DataIC50:  101nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305870(6-(4-(dimethylamino)phenyl)-5-methyl-3-phenylisoxa...)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305872(5-methyl-3-phenyl-6-(4-propylphenyl)isoxazolo[4,5-...)
Affinity DataIC50:  150nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305875(6-(3-fluoro-4-methoxyphenyl)-5-methyl-3-phenylisox...)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305866(5-methyl-6-phenyl-3-(pyridin-3-yl)isoxazolo[4,5-c]...)
Affinity DataIC50:  240nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50589650(CHEMBL5202961)
Affinity DataIC50:  263nMAssay Description:Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50589650(CHEMBL5202961)
Affinity DataIC50:  263nMAssay Description:Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50531687(CHEMBL4445682)
Affinity DataIC50:  347nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50531687(CHEMBL4445682)
Affinity DataIC50:  347nMAssay Description:Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mob...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50553636(CHEMBL4750685)
Affinity DataIC50:  350nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50531687(CHEMBL4445682)
Affinity DataIC50:  350nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50553631(CHEMBL4739931)
Affinity DataIC50:  370nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50553632(CHEMBL4745605)
Affinity DataIC50:  410nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565027(US11414395, Example 76)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565028(US11414395, Example 77)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565029(US11414395, Example 78)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565030(US11414395, Example 79)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565031(US11414395, Example 80)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565035(US11414395, Example 84)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565036(US11414395, Example 85)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565038(US11414395, Example 87)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565040(US11414395, Example 89)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565041(US11414395, Example 90)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565042(US11414395, Example 91)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565043(US11414395, Example 92)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565044(US11414395, Example 93)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565045(US11414395, Example 94)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565046(US11414395, Example 95)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565047(US11414395, Example 96)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565048(US11414395, Example 97)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565049(6-(4-chloro-2-methylphenyl)-2-(pyrimidin-2-yl)-5,6...)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565051(US11414395, Example 100)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565052(US11414395, Example 101)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565055(US11414395, Example 104)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM565059(US11414395, Example 108)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM564959(US11414395, Example 6)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM564960(US11414395, Example 7)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM564961(US11414395, Example 8)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Pragma Therapeutics

US Patent
LigandPNGBDBM564962(US11414395, Example 9)
Affinity DataIC50: <500nMAssay Description:The HTRF-based assays from CisBio Bioassays allow the measure of different cell signaling pathways, notably those allowing the determination of the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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