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Found 787 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4C'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183805(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  0.310nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM577094((7S)-10-(4-Chlorophenyl)-8-cyclopropyl-7-methyl-7,...)
Affinity DataIC50: <0.570nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220996(CHEMBL76635)
Affinity DataIC50:  0.580nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221003(CHEMBL432348)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183803(CHEMBL206968 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM14359((+)-1 | (S)-(+)-3-{2-[(3-Cyclopropyloxy-4-diflurom...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183808(CHEMBL383225 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50229040(CHEMBL156140)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220998(CHEMBL76382)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM577126(10-(4-Chloro-3-fluorophenyl)-8-cyclopropyl-7,8-dih...)
Affinity DataIC50:  1.44nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220993(CHEMBL78238)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221004(CHEMBL77999)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183792(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183794(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-((3-(6-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant PDE4C using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220995(CHEMBL77788)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM285598(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Affinity DataIC50:  2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM285598(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)
Affinity DataIC50:  2nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577172(10-(4-Chloro-3-fluorophenyl)-8-cyclopropyl-3,4,7,8...)
Affinity DataIC50:  2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50589219(CHEMBL5193314)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]-cAMP from full-length recombinant human PDE4C1 by fluorescence polarisation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM285534(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Affinity DataIC50:  2.35nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM285534(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Affinity DataIC50:  2.35nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577123(10-(4-Chloro-5-fluoro-2-methylphenyl)-8-cyclopropy...)
Affinity DataIC50:  2.45nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50229041(CHEMBL351567)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50228824(CHEMBL2112408)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of [3H]- rolipram binding to rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM577128(2-Chloro-5-(8-cyclopropyl-9-oxo-6,7,8,9-tetrahydro...)
Affinity DataIC50:  2.88nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577142(10-(4-Chloro-2-fluorophenyl)-8-cyclopropyl-7,8-dih...)
Affinity DataIC50:  2.88nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174018((E)-N-isopropyl-3-(3-(6-isopropylquinolin-8-yl)phe...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50559699(CHEMBL4759270)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50559704(CHEMBL4752341)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50559702(CHEMBL4750999)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50548531(CHEMBL4747201)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PDE4C catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50559700(CHEMBL4784887)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50559703(CHEMBL4757093)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50559701(CHEMBL4787980)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50228833(CHEMBL318836)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of [3H]- rolipram binding to rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM577143(10-(3-Chlorophenyl)-8-cyclopropyl-7,8-dihydropyrid...)
Affinity DataIC50:  3.16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50229038(CHEMBL345917)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174017(8-(3-(2-(3-methylcyclopenta-1,3-dienyl)-2-(4-(meth...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM577131(8-Cyclopropyl-10-(4-fluoro-3-methylphenyl)-7,8-dih...)
Affinity DataIC50:  3.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174017(8-(3-(2-(3-methylcyclopenta-1,3-dienyl)-2-(4-(meth...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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