Affinity DataIC50: 2.80E+3nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of calf thymus DNA topoisomerase 1 assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by Genview nucleic acid stai...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of calf thymus DNA topoisomerase 1 assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by Genview nucleic acid stai...More data for this Ligand-Target Pair
Affinity DataIC50: 3.75E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
TargetDNA topoisomerase I(Molluscum contagiosum virus subtype 1)
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:DNA cleavage and religation activity as inhibition of type 1B topoisomerase of molluscum contagiosum virus (MCV)More data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
TargetDNA topoisomerase I(Molluscum contagiosum virus subtype 1)
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 7.50E+4nMAssay Description:DNA cleavage and religation activity as inhibition of type 1B topoisomerase of molluscum contagiosum virus (MCV)More data for this Ligand-Target Pair
Affinity DataIC50: 3.07E+5nMAssay Description:Inhibition of calf thymus gland topoisomerase 1 mediated DNA relaxationMore data for this Ligand-Target Pair
Affinity DataIC50: 3.07E+5nMAssay Description:Inhibition of calf thymus gland topoisomerase 1 mediated DNA relaxationMore data for this Ligand-Target Pair
Affinity DataKd: 5.30E+5nMAssay Description:Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L mutant after 24 hrs by equilibrium dia...More data for this Ligand-Target Pair
Affinity DataKd: 7.60E+5nMAssay Description:Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L, K430N mutant after 24 hrs by equilibr...More data for this Ligand-Target Pair