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Found 18 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase I'
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246595(Camptothecin (CPT))
Affinity DataIC50:  2.80E+3nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246595(Camptothecin (CPT))
Affinity DataIC50:  4.20E+3nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246594(Bi-lawsone analog, 3d)
Affinity DataIC50:  1.30E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246593(Bi-lawsone analog, 3c)
Affinity DataIC50:  1.40E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246591(Bi-lawsone analog, 3a)
Affinity DataIC50:  1.60E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246592(Bi-lawsone analog, 3b)
Affinity DataIC50:  1.70E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I(Bos taurus)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50529605(CHEMBL4569028)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of calf thymus DNA topoisomerase 1 assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by Genview nucleic acid stai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I(Bos taurus)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50529605(CHEMBL4569028)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of calf thymus DNA topoisomerase 1 assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by Genview nucleic acid stai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246592(Bi-lawsone analog, 3b)
Affinity DataIC50:  3.75E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I(Molluscum contagiosum virus subtype 1)
University Of California

Curated by ChEMBL
LigandPNGBDBM50088251(4,4',7,7'-tetrabromo-3,3,3',3'-tetramethyl-1,1'-sp...)
Affinity DataIC50:  5.00E+4nMAssay Description:DNA cleavage and religation activity as inhibition of type 1B topoisomerase of molluscum contagiosum virus (MCV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246591(Bi-lawsone analog, 3a)
Affinity DataIC50:  5.10E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246594(Bi-lawsone analog, 3d)
Affinity DataIC50:  7.00E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246593(Bi-lawsone analog, 3c)
Affinity DataIC50:  7.40E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I(Molluscum contagiosum virus subtype 1)
University Of California

Curated by ChEMBL
LigandPNGBDBM50088252(3,3,3',3'-tetramethyl-1,1'-spirobi(indan)-4,4',7,7...)
Affinity DataIC50:  7.50E+4nMAssay Description:DNA cleavage and religation activity as inhibition of type 1B topoisomerase of molluscum contagiosum virus (MCV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I(Bos taurus)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50410161(CHEMBL191804)
Affinity DataIC50:  3.07E+5nMAssay Description:Inhibition of calf thymus gland topoisomerase 1 mediated DNA relaxationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I(Bos taurus)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50164888(6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...)
Affinity DataIC50:  3.07E+5nMAssay Description:Inhibition of calf thymus gland topoisomerase 1 mediated DNA relaxationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataKd:  5.30E+5nMAssay Description:Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L mutant after 24 hrs by equilibrium dia...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute Of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataKd:  7.60E+5nMAssay Description:Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L, K430N mutant after 24 hrs by equilibr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed