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Found 89 Enz. Inhib. hit(s) with Target = 'Ryanodine receptor 1'
TargetRyanodine receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50051434(10-epi-hydroxy-Ryanodine | CHEMBL308183 | Ryanodin...)
Affinity DataKi:  1.80nMAssay Description:Binding to ryanodine receptor in canine cardiac membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430056(US10538528, Compound 43)
Affinity DataIC50:  0.400nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430057(US10538528, Compound 44)
Affinity DataIC50:  0.5nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430051(US10538528, Compound 37)
Affinity DataIC50:  0.5nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430052(US10538528, Compound 39)
Affinity DataIC50:  0.600nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430053(US10538528, Compound 40)
Affinity DataIC50:  0.600nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430047(US10538528, Compound 32)
Affinity DataIC50:  0.600nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430030(US10538528, Compound 11)
Affinity DataIC50:  0.700nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430029(US10538528, Compound 5)
Affinity DataIC50:  0.700nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430034(US10538528, Compound 16)
Affinity DataIC50:  0.800nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430050(US10538528, Compound 34)
Affinity DataIC50:  0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430038(US10538528, Compound 20)
Affinity DataIC50:  0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430066(US10538528, Compound 38)
Affinity DataIC50:  0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430037(US10538528, Compound 19)
Affinity DataIC50:  0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430063(US10538528, Compound 10)
Affinity DataIC50:  0.900nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430049(US10538528, Compound 33)
Affinity DataIC50:  1nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430059(US10538528, Compound 6)
Affinity DataIC50:  1nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430035(US10538528, Compound 17)
Affinity DataIC50:  1.10nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430033(US10538528, Compound 15)
Affinity DataIC50:  1.10nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430062(US10538528, Compound 9)
Affinity DataIC50:  1.10nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044989((O10eq)-beta-guanidinopropionylryanodine | CHEMBL2...)
Affinity DataIC50:  1.10nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430055(US10538528, Compound 42)
Affinity DataIC50:  1.20nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430039(US10538528, Compound 21)
Affinity DataIC50:  1.30nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430036(US10538528, Compound 18)
Affinity DataIC50:  1.40nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430031(US10538528, Compound 13)
Affinity DataIC50:  1.40nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430041(US10538528, Compound 23)
Affinity DataIC50:  1.5nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430058(US10538528, Compound 2)
Affinity DataIC50:  1.5nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430028(US10538528, Compound 1)
Affinity DataIC50:  1.5nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430065(US10538528, Compound 35)
Affinity DataIC50:  1.5nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430054(US10538528, Compound 41)
Affinity DataIC50:  1.60nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430060(US10538528, Compound 7)
Affinity DataIC50:  1.70nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430032(US10538528, Compound 14)
Affinity DataIC50:  1.70nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430045(US10538528, Compound 30)
Affinity DataIC50:  1.70nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430061(US10538528, Compound 8)
Affinity DataIC50:  1.70nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044982(CHEMBL283836 | GLYCYLRYANODINE)
Affinity DataIC50:  1.80nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044986((O10eq)-guanidino acetylryanodine | CHEMBL435362)
Affinity DataIC50:  1.80nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430064(US10538528, Compound 12)
Affinity DataIC50:  1.80nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430044(US10538528, Compound 27)
Affinity DataIC50:  1.80nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430046(US10538528, Compound 31)
Affinity DataIC50:  1.80nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044994(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 2 hr by com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044995((O10eq)-beta-alanylryanodine | CHEMBL282089)
Affinity DataIC50:  2.60nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50051434(10-epi-hydroxy-Ryanodine | CHEMBL308183 | Ryanodin...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against ryanodine receptor from mouse brain preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044994(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 1 hr by com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50051434(10-epi-hydroxy-Ryanodine | CHEMBL308183 | Ryanodin...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against ryanodine receptor from rabbit muscle preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044993(Benzyloxycarbonyl-glycylryanodine | CHEMBL28383)
Affinity DataIC50:  4.80nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044990((O10eq)-Benzyloxycarbonyl-beta-alanylryanodine | C...)
Affinity DataIC50:  5.90nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044994(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  6.20nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044991(2,6,9,11,13,14-hexahydroxy-11-isopropyl-7,10-dimet...)
Affinity DataIC50:  8.90nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044994(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016403(2,6,9,11,13,14-hexahydroxy-11-isopropyl-7,10-dimet...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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